Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.1.1 (hexokinase)
 5,274 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The activities of hexokinase, citrate-cleavage enzyme, ;malic enzyme' and NADP-linked isocitrate dehydrogenase have been measured in the adipose tissue, testes and adrenals of normal rats, hypophysectomized rats and hypophysectomized rats treated with either thyroxine or thyroxine plus luteinizing hormone. Hypophysectomy reduced the activity of all four enzymes in all three tissues. Thyroxine alone restored the activity of all four enzymes in adipose tissue towards normal but failed to do so in either testes or adrenals. Thyroxine and luteinizing hormone restored the citrate-cleavage enzyme activity of testes and increased the activity of hexokinase from the low value after hypophysectomy. Neither ;malic enzyme' nor isocitrate dehydrogenase was increased by thyroxine or thyroxine and luteinizing hormone in testes. The differential stimulation of enzyme activity by thyroxine in the different tissues suggests thyroxine as having a special significance in adipose-tissue lipogenesis.
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PMID:Influence of thyroxine and luteinizing hormone on some enzymes concerned with lopogenesis in adipose tissue, testis and adrenal gland. 600 41

The influence of thyroxine on some of the key enzymes involved in glycolytic and pentose phosphate pathways in the testes of pre-pubertal; pubertal and adult rats was studied. Thyroxine-induced (25 micrograms/100 g body weight) hyperthyroidism for 1 month resulted in no change in either hexokinase (EC 2.7.1.1) or 6-phosphofructokinase (EC 2.7.1.11) activity in the testes of rats in any age group studied. However, pyruvate kinase (EC 2.7.1.40) activity was reduced significantly in the pre-pubertal and pubertal rats. Both glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and 6-phosphogluconate dehydrogenase (EC 1.1.1.44) activities were markedly increased after thyroxine treatment. Withdrawal of hormone treatment resulted in reversion of enzyme activities towards normal. The results suggest that thyroxine has an age-dependent, specific effect over testicular pyruvate kinase activity. Thyroid hormone may have a direct control over the pentose phosphate pathway in the testis.
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PMID:Specific effect of thyroid hormone on testicular enzymes involved in carbohydrate metabolism. II. Hyperthyroidism. 646 78