Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.1.1 (
hexokinase
)
5,274
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hexokinase-2 is overexpressed in several carcinomas including breast cancer to sustain energy for rapidly dividing cells and associates with chemoresistance. However, the impact of chemo drugs (alone or in combination) on
hexokinase
activity and autophagic cell death is unclear. In this report, we used an in vivo murine adenocarcinoma model to validate the effects of As
2
O
3
and cisplatin on
hexokinase
activity and autophagic cancer cell death. We found that the two drugs inhibit
hexokinase
activity and induce autophagic marker,
beclin 1
expression. Interestingly, combining As
2
O
3
with cisplatin synergistically enhanced these effects and alleviated oxidative stress often encountered in As
2
O
3
treatment. Altogether, our data provide direct evidence that inhibition of
hexokinase
activity and induction of autophagic cell death are mediating the antineoplastic effects of As
2
O
3
and cisplatin. Our findings raise the potential of combining As
2
O
3
with cisplatin as an approach to augment cisplatin-induced cell death and combat cisplatin chemoresistance in cancer.
...
PMID:Combination of arsenic trioxide and cisplatin synergistically inhibits both hexokinase activity and viability of Ehrlich ascites carcinoma cells. 3114 61
