Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.1.1 (
hexokinase
)
5,274
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A major fraction of
hexokinase
was found to be bound, presumably to mitochondria, in both normal and tumoral rat pancreatic islet cells examined after either mechanical disruption or digitonin treatment.
Spermidine
enhanced the binding and glucose 6-phosphate caused the release of
hexokinase
to and from islet mitochondria, in a manner comparable to that seen in parotid or brain homogenates. In hepatocytes, some
hexokinase
, but no glucokinase, was found in the bound form. In islet cells, however, the pattern of glucokinase binding was similar to that of
hexokinase
. It is speculated that the preferential location of both
hexokinase
and glucokinase on mitochondria may favor the maintenance of a high cytosolic ATP content in islet cells.
...
PMID:Hexose metabolism in pancreatic islets: regulation of mitochondrial hexokinase binding. 328 98
