Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.1.1 (
hexokinase
)
5,274
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The activity of carbohydrate metabolism certain enzymes [
hexokinase
(
EC 2.7.1.1
.), glucokinase (EC 2.7.1.2), phosphofructokinase (EC 2.7.1.11.1), glucoso-6-phosphate-dehydrogenase (EC 1.1.1.49.)] was studied in the sheep skin when adding vitamin A, sodium sulphate and insulin to the basic ration. The activity of the studied enzymes in the skin was established to be rather high and depend to a considerable extent on feeding, seasonal and hormonal factors. In summer the activity of such enzymes as glucoso-6-phosphate-dehydrogenase and glucokinase decreases, and that of
hexokinase
, vice versa, increases.
Vitamin A
alone against a background of the basic ration almost has no effect on the activity of the enzymes, with the exception of phosphofructokinase in certain periods of the experiment. More noticeable shifts in the activity of the enzymes were observed in the case when vitamin A and sodium sulphate were added to the ration of sheep, and also with the injection of insulin. In such cases in the sheep skin there occurs first of all an increase in the activity of glucokinase and glucoso-6-phosphate-dehydrogenase.
...
PMID:[Activity of some carbohydrate-metabolizing enzymes in sheep skin]. 13 Jul 4
Vitamin A
toxicity, caused by oral administration of 30,000 IU of vitamin A (retinyl palmitate) to young rats (70 to 90 g) once daily for 2 days, increased the levels of lipids, glycogen, and citrate in the liver. Furthermore, hypervitaminosis A decreased the activities of two key hepatic glycolytic enzymes, phosphofructokinase, and pyruvate kinase, without affecting those of
hexokinase
and glucokinase. It is suggested, therefore, that in addition to the increased activities of key gluconeogenic enzymes, reported earlier, a marked decrease in the activities of phosphofructokinase and pyruvate kinase and elevated level of citrate in the liver could account for the enhanced gluconeogenesis in hypervitaminosis A.
...
PMID:Early effects of vitamin A toxicity on hepatic glycolysis in rat. 15 4
The effect of 1 to 5 doses of 15,000 I.U. of vitamin A on some enzymes of the carbohydrate metabolism in gingival tissue from rats was studied.
Vitamin A
feeding resulted in a significant increase in the activities of
hexokinase
and pyruvate kinase with the different doses tested. A reduction in the activity of phosphofructokinase was observed with 2 and 4 doses. The administration of ascorbic acid along with vitamin A, did not prevent the effects of vitamin A on the activities of the enzymes studied. The data on the enzyme activities in the groups simultaneously fed on vitamin A and cortisol may indicate an additive effect of these compounds.
...
PMID:Excess vitamin A and the metabolism of carbohydrates: variation of enzyme activities in gingiva of rats submitted to excess vitamin A, vitamin A plus cortisol and vitamin A plus ascorbic acid. 667 73
