Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.1.1 (
hexokinase
)
5,274
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The yeast Yarrowia lipolytica produces an extracellular lipase encoded by the
LIP2
gene. However, very little is known about the mechanisms controlling its expression, especially on glucose media. In this work, the involvement of
hexokinase
Hxk1 in the glucose catabolite repression of
LIP2
was investigated in a lipase overproducing mutant less sensitive to glucose repression. This mutant has a reduced capacity to phosphorylate hexose compared with the wild-type strain, but no differences could be observed between the HXK1 sequences in the two isolates. This suggested that the reduced phosphorylating activity of the mutant strain probably resulted from a modification in the level of HXK1 expression. However, overexpression of the HXK1 gene in this mutant led to a decrease of both
LIP2
induction and extracellular lipase activity, suggesting that the
hexokinase
is involved in the glucose catabolite repression of
LIP2
in Y lipolytica.
...
PMID:Involvement of hexokinase Hxk1 in glucose catabolite repression of LIP2 encoding extracellular lipase in the yeast Yarrowia lipolytica. 1588 72
