Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.1.1 (hexokinase)
 5,274 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The hypertrophied left ventricles of renovascular hypertensive Wistar rats were examined for several enzyme activities 4-6 and 8-12 weeks after operation (Goldblatt-II), and compared with controls. The activities of beta-hydroxyacyl-CoA dehydrogenase in hypertrophied myocardial tissue were found to be markedly diminished, as were those of citrate synthase, although to a lesser degree. In both stages of left ventricular hypertrophy hexokinase activity was considerably increased, whereas that of lactate dehydrogenase was only initially slightly elevated. Both enzymes showed an altered isoenzyme composition. The possible reasons and consequences of these changes are discussed.
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PMID:Left ventricular enzyme activities of the energy-supplying metabolism in Goldblatt-II rats. 404 51

The present study was undertaken in order to investigate the behavior of lactate dehydrogenase (LDH) and hexokinase (HK) in the mechanically overloaded and the postnatally developing left ventricle of the rat. In Goldblatt rats (GBR) 2 to 4 months after operation total LDH activity was decreased by 7%, accompanied by an isoenzyme shift towards a higher M proportion. Swimming rats (SR) showed an 11% increase in LDH activity. HK activity was increased by 14% in GBR and unaltered in SR. Histochemical investigations revealed no indication of heterogeneous alterations in various areas of the myocardium. During postnatal development, a gradual increase of activity and H subunit proportion of LDH were observed. HK activity was increased after one week, but underwent a slow decreased thereafter. These changes are interpreted as processes of adaptation to the conditions of extrauterine life.
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PMID:The behavior of some enzymes of the hypertrophied and postnatally developing myocardium of the rat. 644 92