Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
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Human Gene/Protein
alanine aminotransferase 13720
aspartate aminotransferase 8708
AST 4535
alkaline phosphatase 3644
GPT 2403
lactate dehydrogenase 1854
superoxide dismutase 1778
GSH 1757
albumin 1746
Sep 1700
catalase 1400
interferon 1191
TNF 1155
glutathione peroxidase 1028
ALP 1007
LDH 989
insulin 986
tumor necrosis factor 970
hemoglobin 823
Mol 763
IL-6 715
creatine kinase 694
cytokine 637
lipopolysaccharide 616
SOD 611
caspase-3 572
HDL 558
IFN 539
GGT 526
collagen 515
glutamate pyruvate transaminase 502
surface antigen 489
prothrombin 443
galactosamine 408
gamma-glutamyltransferase 363
inducible nitric oxide synthase 362
serum albumin 358
myeloperoxidase 350
C-reactive protein 348
interleukin-6 336
CAT 323
glutamate dehydrogenase 316
IL-10 308
amylase 302
glutathione reductase 294
gamma-glutamyl transpeptidase 284
Bcl-2 264
microsomal 257
LPS 256
glutathione S-transferase 249
cytochrome P450 247
CD4 245
ATP 234
ferritin 231
TNF-alpha 218
GTG 214
interferon-alpha 214
heme oxygenase-1 201
TLR4 198
sorbitol dehydrogenase 195
acid phosphatase 192
Nrf2 190
gut 188
tumor necrosis factor alpha 187
endoplasmic reticulum 186
lipase 186
antioxidant enzyme 185
CYP2E1 181
She 171
SMA 171
fibrinogen 165
Aspartate aminotransferase 164
GST 163
adiponectin 161
CD8 154
ROS 154
p65 148
p53 147
serum protein 145
cytochrome P-450 145
CPK 143
erythroid 140
smooth muscle actin 139
leptin 137
CRP 137
proliferating cell nuclear antigen 132
JNK 131
HO-1 126
acetylcholinesterase 124
peroxisome proliferator-activated receptor 118
alpha-fetoprotein 116
p38 115
interferon alpha 115
COX-2 114
transferrin 113
thromboplastin 111
thymus 110
MAPK 108
IL-4 107
PPAR 106
IL-2 105
cyclooxygenase-2 105
cytochrome 103
nitric oxide synthase 103
glucose-6-phosphate dehydrogenase 103
lysozyme 102
ATPase 101
carp 101
Pol 100
Fas 100
gamma-glutamyltranspeptidase 99
cytochrome P450 2E1 98
glutamine synthetase 96
IFN-gamma 94
fatty acid synthase 91
alcohol dehydrogenase 91
phosphatase 91
NAD 89
malate dehydrogenase 88
caspase-9 88
HSP70 87
cytochrome c 87
pyruvate kinase 87
chemokine 86
peroxidase 85
IL-1 85
Alanine aminotransferase 84
glycoprotein 83
Alkaline phosphatase 83
kit 83
IgA 82
AMPK 82
NMR 82
reductase 81
metallothionein 81
P450 81
IL-8 80
lymphoid 80
Cytokine 79
MCP-1 78
isocitrate dehydrogenase 77
GTP 76
NADPH 76
HCC 75
glucose-6-phosphatase 75
RIN 74
ERK 74
AFP 74
mTOR 73
A-I 73
FIB 73
phosphoenolpyruvate carboxykinase 71
vascular endothelial growth factor 70
PI3K 70
PEG 70
NADH 69
xenobiotic 69
alpha-smooth muscle actin 69
epididymal 69
interleukin 6 69
more...
Disease
chronic hepatitis 2284
hepatitis 1869
hepatitis B 1775
GSH 1757
hepatitis C 1686
cirrhosis 1477
liver disease 1445
fatty liver 1030
hepatocellular carcinoma 1004
cancer 977
diabetes 809
ischemia 790
tumor 772
liver fibrosis 736
obesity 667
viremia 427
cholestasis 426
acute hepatitis 418
HIV 410
viral hepatitis 391
chronic liver disease 381
sepsis 354
sepsis 326
metabolic syndrome 315
thrombocytopenia 309
alcoholic fatty liver 308
anemia 307
hypertension 302
virus infection 290
type 2 diabetes 283
chronic active hepatitis 270
Nonalcoholic fatty liver 261
cold 247
pneumonia 235
hyperlipidemia 234
rash 210
liver cancer 207
immunodeficiency 207
depression 204
hyperglycemia 193
infectious diseases 190
hepatitis A 184
Hepatotoxicity 173
neutropenia 157
carcinoma 154
dyslipidemia 154
eosinophilia 154
cardiovascular disease 148
hypercholesterolemia 139
leukopenia 131
pruritus 129
lymphoma 129
atherosclerosis 128
liver cancer 122
breast cancer 120
carcinogenesis 119
primary biliary cirrhosis 117
myocardial infarction 114
hyperbilirubinemia 114
hepatitis E 113
tuberculosis 112
alcoholism 110
AIDS 108
urinary tract infection 107
iron overload 106
renal disease 106
proteinuria 105
bronchitis 103
alcohol abuse 102
cytomegalovirus 102
hypoglycemia 95
tumor growth 95
chronic persistent hepatitis 94
renal failure 91
Chronic hepatitis B 88
stroke 87
portal hypertension 85
malnutrition 84
cholangitis 83
leukemia 81
hepatic encephalopathy 81
gallstones 79
tonsillitis 79
hepatitis G 78
dengue 77
HCC 75
acute pancreatitis 74
rheumatoid arthritis 73
Infection 72
metastases 71
glucose intolerance 71
malaria 70
arthritis 69
pancreatitis 68
alcoholic hepatitis 67
influenza 65
encephalopathy 65
thalassemia 65
West 64
Haemophilus 63
lymphadenopathy 63
Epstein 60
ACP 60
myopathy 59
B-cell lymphoma 59
acute renal failure 59
bronchitis 58
Acute liver failure 58
Klebsiella 57
meningitis 57
Chronic hepatitis C 57
lymphadenitis 57
heart failure 56
coagulopathy 56
disseminated intravascular coagulation 55
adenocarcinoma 54
lung cancer 54
Hepatocellular carcinoma 54
hyperinsulinemia 53
hepatitis D 53
posttransfusion hepatitis 53
obstructive jaundice 53
schistosomiasis 53
dehydration 53
hypothyroidism 52
biliary obstruction 50
coma 50
Cirrhosis 49
haemophilia 48
SEM 48
peritonitis 47
EIA 47
acute myeloid leukemia 47
fits 46
systemic lupus erythematosus 46
bronchopneumonia 45
melanoma 45
NAME 45
lymphopenia 44
Wilson's disease 44
uterus 44
hyperthyroidism 44
graft-versus-host disease 43
LAP 43
sickle cell disease 42
tumorigenesis 42
plaque 42
NS3 41
Alcoholic liver disease 41
thrombocytosis 41
acute myocardial infarction 41
primary sclerosing cholangitis 40
MIP 40
pyelonephritis 40
epilepsy 39
enteritis 38
hemorrhagic fever 38
FAS 37
prostate cancer 37
colitis 37
more...
Symptom
diarrhea 433
fatigue 280
vomiting 263
nausea 233
hepatomegaly 222
anorexia 200
anesthesia 196
pain 190
abdominal pain 161
overweight 148
headache 118
weakness 98
splenomegaly 90
myalgia 83
lethargy 76
cough 71
nausea and vomiting 71
Ill 62
arthralgia 55
starvation 54
dyspnea 54
seizures 53
hypothermia 46
erythema 45
hepatosplenomegaly 42
chills 33
constipation 31
collapse 30
exhaustion 29
epigastric pain 29
hypoproteinemia 28
respiratory distress 28
discomfort 23
dizziness 23
asthenia 23
tremor 23
polyuria 22
oliguria 22
discomfort 22
decreased appetite 21
analgesia 21
polydipsia 19
ataxia 18
sleepiness 17
sore throat 17
insomnia 17
right upper quadrant pain 16
chest pain 15
agitation 15
emaciation 14
angina 13
acidity 13
fever of unknown origin 13
functional recovery 12
numbness 12
flushing 12
abdominal discomfort 11
dark urine 11
cachexia 11
tachypnea 10
pallor 9
back pain 9
shortness of breath 9
hypotonia 9
skin irritation 8
thinning 8
paresthesia 8
hyperoxia 8
apathy 8
syncope 7
nasal discharge 7
colic 7
vertigo 6
acute abdominal pain 6
regurgitation 6
paresis 6
hot flushes 6
No adverse effect 5
incoordination 5
dysuria 5
consciousness disturbance 5
night sweats 5
acute stress 5
spasm 5
tingling 5
urinary frequency 5
jaundice of the skin 5
hemoptysis 4
rigors 4
cyanosis 4
rhinorrhea 4
hunger 4
hyperemesis gravidarum 4
hypocapnia 4
bone pain 4
intestinal bleeding 4
low back pain 4
stomach pain 4
muscle cramps 4
HSA 4
muscle rigidity 4
nasal congestion 4
Welt 4
acute abdomen 4
abdominal cramps 4
memory loss 4
Flare 3
asterixis 3
retching 3
tinnitus 3
hypercapnia 3
wheezing 3
tonic-clonic seizure 3
leg pain 3
menopausal symptoms 3
leg edema 3
dysarthria 3
Gastrointestinal symptoms 3
excessive sweating 3
muscle stiffness 3
spasticity 3
myoclonus 3
abdominal fullness 3
lassitude 3
flank pain 3
Wind 3
hangover 3
adenitis 3
ataxic gait 3
despair 3
bloating 3
ketonuria 3
prostration 3
Decreased activity 3
exertional dyspnea 3
stridor 2
livedo 2
hot flashes 2
body pain 2
dry skin 2
Flu-like symptoms 2
cerebellar ataxia 2
cancer pain 2
non-productive cough 2
anal pain 2
Murphy's sign 2
drooling 2
periorbital edema 2
labored breathing 2
neck pain 2
staggering gait 2
impaired motor coordination 2
dystonia 2
CSR 2
mental fatigue 2
neuralgia 2
ophthalmoplegia 2
stigma 2
clubbing 2
knee pain 2
more...
Drug
vitamin E 262
ascorbate 204
ROS 154
Ethanol 115
IL-2 105
IFN-gamma 93
lysine 74
NADH 65
Monit 65
Albumin 62
ROC 62
Glutathione 56
CSF 54
Alanine 54
pyridoxal phosphate 53
caffeine 49
EE2 48
Cardiovasc 46
Vitamin E 43
Dermatol 41
ENT 41
Serum albumin 41
ALA 39
Portal 38
CTX 34
Bifidobacterium 31
ampicillin 31
Nephron 29
Nephron 29
MAP 28
PMEA 27
Entecavir 26
Entecavir 26
CCL 25
SBT 24
Vitamin B 22
Dial 22
Heme 21
ZnO 21
Ringer's solution 21
Fructose 21
AZT 21
Simvastatin 21
NH3 21
Leaf 21
Biopolymers 21
NAG 21
TAC 20
citric acid 20
Rosiglitazone 19
lactose 19
Isoniazid 18
Fraction 18
Glycyrrhiza 18
Ginseng 17
niacin 16
CTX 16
Adefovir dipivoxil 16
CTX 16
PMPA 15
IFN-beta 15
IPM 15
PTH 15
Telbivudine 15
G-CSF 14
Vitamin A 14
TAK 14
CPZ 14
Aloe 13
AZT 13
Tacrolimus 13
Acacia 13
CDZM 12
Prednisolone 12
Tenofovir 12
Rutin 12
Troglitazone 12
Adriamycin 11
Rosuvastatin 11
OTC 11
Retinoic acid 10
Mutagen 10
Prednisone 10
Gel 10
Nitric Oxide 10
CEZ 9
PCB 9
Lipiodol 9
FAD 9
Ceftazidime 9
CMZ 9
Azithromycin 9
PAPM/BP 9
Norplant 9
CZOP 9
Sorafenib 9
Ximelagatran 9
Ganciclovir 9
TiO2 8
CPR 8
ZnCl2 8
Emodin 8
Emodin 8
Isotretinoin 8
ZnCl2 8
Lovastatin 8
Indomethacin 8
ETA 8
Liraglutide 7
Docetaxel 7
Infliximab 7
Bosentan 7
Lead acetate 7
ABC 7
Ketoconazole 7
DMI 7
EPA 7
ADR 7
Bosentan 7
Aminoguanidine 7
CTM 7
Fluorescein 7
DM1 7
AMC 7
Infliximab 7
Furan 7
Ezetimibe 7
Histamine 7
Swertia 6
CZON 6
TAT 6
Olive oil 6
Kenyan 6
Rituximab 6
Itraconazole 6
Cefprozil 6
ACT 6
Capsicum 6
MRC 6
Indocyanine green 6
LMOX 6
ADM 6
ICI 6
HCH 6
Clofibrate 6
Ranitidine 6
BLM 6
MEPM 6
p75 6
Pegasys 6
Fluconazole 6
DPA 6
Caspofungin 6
Intron A 5
RFP 5
FMOX 5
Glucagon 5
Doxycycline 5
NVP 5
Honey 5
more...
Enzyme
alanine aminotransferase 26722
aspartate aminotransferase 13093
AST 4535
alkaline phosphatase 3647
superoxide dismutase 2325
lactate dehydrogenase 2024
catalase 1690
gamma-glutamyl transpeptidase 1643
glutathione peroxidase 1045
creatine kinase 924
peroxidase 438
caspase-3 433
glutathione S-transferase 414
mitogen-activated protein kinase 339
glutamate dehydrogenase 328
glutamate dehydrogenase 328
glutamate dehydrogenase 327
acetylcholinesterase 315
glutathione reductase 295
cholinesterase 250
sorbitol dehydrogenase 195
lipase 194
acid phosphatase 192
ERK 174
AMP-activated protein kinase 141
glucose-6-phosphate dehydrogenase 128
malate dehydrogenase 125
protein kinase 122
ATPase 120
thromboplastin 116
lysozyme 103
alcohol dehydrogenase 101
glutamine synthetase 97
reverse transcriptase 97
aldolase 91
isocitrate dehydrogenase 90
aldehyde dehydrogenase 89
pyruvate kinase 88
focal adhesion kinase 86
phosphoenolpyruvate carboxykinase 83
AMPK 82
AMPK 82
phosphoenolpyruvate carboxykinase 81
phosphoenolpyruvate carboxykinase 80
isocitrate dehydrogenase 78
glucose-6-phosphatase 76
ceruloplasmin 71
demethylase 68
collagenase 67
arginase 67
caspase-9 66
succinate dehydrogenase 64
heme oxygenase 64
NQO1 63
thrombin 61
xanthine oxidase 61
transpeptidase 58
NO synthase 55
acetyl-CoA carboxylase 53
DNA polymerase 53
hexokinase 52
CYP3A4 48
luciferase 48
CPT 48
PARP 48
ACE 47
leucine aminopeptidase 46
aldehyde dehydrogenase 44
caspase-1 44
5'-nucleotidase 42
citrate synthase 42
CPR 41
lipoprotein lipase 40
alpha-amylase 40
aldehyde dehydrogenase 40
MIP 40
aldehyde dehydrogenase 40
aldehyde dehydrogenase 40
ornithine transcarbamylase 39
trypsin 38
tyrosine aminotransferase 38
glucokinase 37
phosphorylase 36
UDP-glucuronosyltransferase 35
gamma-glutamylcysteine synthetase 35
caspase-8 34
pyruvate dehydrogenase 34
delta-aminolevulinic acid dehydratase 34
adenosine deaminase 33
RNA polymerase 32
glutaminase 31
NOS 31
phosphofructokinase 31
beta-glucuronidase 30
GLO 30
MDH 30
MDH 30
GSK 29
protein kinase C 28
beta-lactamase 28
ornithine decarboxylase 27
6-phosphogluconate dehydrogenase 27
6-phosphogluconate dehydrogenase 27
CYP7A1 26
lactic acid dehydrogenase 26
pyruvate carboxylase 26
type III procollagen 26
NADPH oxidase 25
complex I 25
adenosine deaminase 25
NADPH oxidase 24
CPT 24
fructose 1,6-bisphosphatase 24
CPT 24
transcriptase 22
glyceraldehyde-3-phosphate dehydrogenase 22
phosphoglucomutase 22
GABA transaminase 22
pyruvate dehydrogenase 22
pyruvate dehydrogenase 22
phosphoglucose isomerase 21
thymidine kinase 21
ACS 21
ECH 20
diaphorase 20
cytochrome oxidase 20
phospholipase A2 20
renin 20
paraoxonase 20
glutamate decarboxylase 19
elastase 19
glyceraldehyde-3-phosphate dehydrogenase 19
diamine oxidase 18
APC 18
phosphodiesterase 18
MAP 18
guanase 18
alpha-ketoglutarate dehydrogenase 18
paraoxonase 18
purine nucleoside phosphorylase 18
adenylate kinase 17
lactic acid dehydrogenase 17
PGM 17
phosphatidylinositol 3-kinase 17
glutamate synthase 17
lactic acid dehydrogenase 17
carboxylesterase 17
proteasome 17
MEK 16
glutamate synthase 16
glyceraldehyde-3-phosphate dehydrogenase 16
glutamate synthase 16
MMP 16
neutrophil elastase 16
LPL 16
nucleotidase 15
phosphoinositide 3-kinase 15
monoamine oxidase 15
nitrate reductase 15
3-hydroxy-3-methylglutaryl coenzyme A reductase 14
more...
Compound
glucose 2576
creatinine 2473
GPT 2403
DNA 2197
urea 2147
Dec 1856
GSH 1803
GSH 1803
Clin 1625
water 1279
TNF 1155
nitrogen 1054
ALP 1007
oxygen 983
ethanol 909
sodium 800
CCl4 752
alanine 731
calcium 656
MDA 584
glutamate 546
nitric oxide 542
APAP 482
iron 472
potassium 452
phosphate 406
CAT 332
CAT 323
CAT 323
ammonia 295
phosphorus 291
methionine 273
zinc 265
acetate 249
ATP 234
cysteine 224
cadmium 224
copper 222
N-acetylcysteine 200
galactose 181
glutamine 172
selenium 163
hydrogen 163
2-oxoglutarate 158
nitrate 157
His 154
arginine 151
sulfate 139
methanol 138
GSSG 135
hyaluronic acid 129
PEG 121
3TC 120
NAD 112
CO2 111
leucine 106
chloroform 105
salt 100
alcohol dehydrogenase 100
DPPH 98
tyrosine 97
PEG 92
Silymarin 91
NAD 89
Asp 87
alloxan 87
ethyl acetate 84
ammonium 82
lysine 81
Curcumin 81
Insulin 79
dUTP 78
serine 77
MTT 77
NADPH 76
GTP 76
NADPH 76
Lactate 75
aniline 74
NH2 73
tryptophan 73
mercury 70
8-OHdG 70
aflatoxin B1 70
aspartic acid 69
tryptophan 67
H2O2 66
silver 66
ornithine 65
ornithine 65
ornithine 65
tryptophan 65
ornithine 65
ornithine 65
NADH 65
tryptophan 65
Hematoxylin 64
homocysteine 64
gallic acid 64
nicotinamide 63
Cholesterol 63
DMSO 63
Malondialdehyde 62
bromobenzene 61
ADP 61
Bilirubin 61
Phe 61
asparagine 60
Glutamate 60
vitamin D 60
threonine 59
glycerol 58
STZ 57
chromium 57
iodine 56
ADP 56
ADP 56
aldehyde 55
Cardiol 55
INH 53
Pac 52
caffeine 52
manganese 52
Alanine 51
Vitamin E 51
glutamic acid 49
6-12 48
Ile 48
DDP 48
Hemoglobin 48
proline 48
Ribavirin 48
Oil Red O 47
MCH 47
Lead 47
TSH 47
CdCl2 46
Ascorbic acid 46
valine 46
Arsenic 45
NADP 45
Melatonin 45
Abbott 45
CoA 44
phenol 44
TCA 44
Oil Red O 44
adenosylmethionine 44
isoleucine 43
isoleucine 43
AMP 43
Adriamycin 42
MIC 42
PMA 41
retinol 41
DBA 41
TAA 41
betaine 40
bromide 40
Quercetin 39
more...