Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.6.1.2 (
alanine aminotransferase
)
26,722
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Some tumors acquire replicative immortality by activating an ALTernative telomerase-independent telomere maintenance mechanism.
ALT
offers interesting therapeutic perspectives but lacks any known specific targets. We discovered a crucial role for
TSPYL5
(Testis-Specific Y-encoded-Like Protein 5) in keeping
ALT
cell viability by protecting POT1 (Protection Of Telomeres 1) from proteasomal degradation.
...
PMID:Specific death of ALT cells through TSPYL5 depletion. 3169 25
