Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serological analysis of the red cells from members of a large French-Canadian kindred proved that the Swa antigen is not part of the P1, Dombrock or Yt blood group systems. A linkage analysis of the SW blood group locus in relation to 27 other loci indicates that SW is not closely linked to ABO, ACP1, ADA, AK1, C3, D2S5, DO, ESD, F13A, FY, GLO1, GPT, HP, IGHG, JK, LU, MYCL, P1, PGP, PGM1, PLG, RH or YT. By inference the study also allows exclusion of Swa from the Landsteiner-Wiener, Radin and Scianna blood group systems and exclusion of SW from the p22.1 to p34 segment of chromosome 1.
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PMID:The Swann phenotype 700:4,-41; genetic studies. 336 42

Linkage relationships to unassigned and provisionally assigned genetic markers were examined from 53 families segregating for various fragile sites. Fragile sites were at Xq27, 2q13, 6p23, 9p21, 9p32, 10q23, 10q25, 11q13, 11q23, 12q13 and 16p12. No new assignments were made but extensive exclusion data are presented for the markers F13A, F13B, CHE2, K, TF, GPT, C3 and Lu arising from linkage comparisons with fragile sites and other genetic markers. Exclusions of at least 10 cM involving fragile site markers were made for F13A (6p23, 9q32, 10q25), F13B (10q23, 10q25, 16p12), CHE2 (16p12), K (10q23), TF (10q23, 10q25, 11q13), GPT (10q23, 10q25, 11q13), C3 (10q23, 10q25) and Lu (10q25, 11q13).
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PMID:A search for linkage in families with fragile sites. 658 Feb 60

Exclusion mapping was applied to individuals with monosomic segments defined by chromosomal banding. A range of genetic markers and blood groups was determined resulting in new exclusions for unassigned markers at the following segments : (3)(p25 leads to pter) - JK, GPT, PI ; (4)(127 leads to 31) - MNS, JK, PI, C3, F13A, F13B ; (7))q22) - LU, F13A ; (12)(p12) - MNS ; (12)(p13) and (15)(q15) - GPT, C3 ; (12) (pter) and (19)(p or qter) - MNS, GPT, PI ; and (18)(q21 leads to 23) - MNS, JK, F13A. These exclusions may be useful for narrowing the regional localisations of any genetic markers subsequently assigned to the chromosome involved in the exclusion. No new gene assignments were made from cases where family data was available.
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PMID:Additions to the exclusion map of man. 697 96