Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The reported investigations were carried out in 18 men aged 19 to 23 years in whom 400 ml of whole blood was removed. On the day before bloodletting, one hour and 24 hours after it the studied men carried out a 10 minute exercise on a Monark cycle ergometer at a workload raising the heart rate to 170/min. Before the exercise, immediately after it and in the 30th minute of restitution venous blood samples were taken for determinations of the concentrations of total protein, albumins, free fatty acids, glucose, lactate and pyruvate, and the activity of lactic dehydrogenase, alanine aminotransferase and aspartate aminotransferase. During that time the acid-base equilibrium was determined in capillary blood. After bloodletting the concentrations of albumins, total protein and free fatty acids were decreased parallelly to haematocrit value decrease (p less than 0.05) and glucose concentration increased slightly (p less than 0.05). Enzyme activity was decreased slightly (p greater than 0.05). The partial oxygen pressure decreased, that of carbon dioxide increased, and hydrogen ion concentration rose. These changes were more pronounced after 24 hours than 1 hour after bloodletting. After submaximal exercise and in the 30th minute of restitution as well as 1 and 24 hours after bloodletting the changes in the concentrations of the biochemical parameters, enzyme activity and acid-base equilibrium were similar as after bloodletting.
Acta Physiol Pol
PMID:Changes in the concentrations of certain biochemical parameters in the peripheral blood during exercise and restitution after bloodletting. 718 May 21

The studies were carried out in 542 chickens of greenleg x polbar crossing. For detailed biochemical studies 443 birds were used. In a series of experiments the author studied the influence of temperature in three ranges: T1 = 12-14 degrees C, T2 = 18-20 degrees C, T3 = 24-26 degrees C on body weight, cholesterol level, basic phosphatase activity AP (E. C. 3.1.3.1), aspartic transaminase activity AspAT (E. C. 2.6.1.1), alanine transaminase activity AlAT (E. C. 2.6.1.2), the value of de Ritisa (WdR) coefficient, the level of total plasma protein including albumin, globulin alpha 1 alpha 2, beta, gamma, and the relation of albumin to globulin. The effect of the thermal factor was studied in the 5th and 8th week of life with regard to bird sex. The content of cholesterol in blood serum increased with the chicken age, in the 5th week--78,36 mg%, in the 8th week--96,9 mg%; the difference was statistically significant. AP and AspAT activity, however, decreased with the age, respectively, in the 5th week--91,46 K-A and 344,7 K units, and in the 8th week--73.61 K-A and 284.9 K units. The effect of the thermal factor caused in blood plasma highly significant differences in the mean AspAT and AlAt activity, in the mean level of WdR, albumin, globulin beta, whereas significant differences in the mean AP activity and mean level of gamma globulins. The highest mean activity of transaminases was obtained at the highest temperatures: AspAT 366.8 K units and AlAT 60,1 K units, whereas AP 95.1 K-A units at optimal temperature. The lowest mean albumin levels were found at T1 = 49.29%, and the highest at T3 = 51.29%.
Pol Arch Weter 1982
PMID:[Effect of a thermal factor on various biochemical indicators in the plasma of chickens]. 718 83

The activity of aspartate aminotransferase and alanine aminotransferase and the content of soluble proteins were determined in mice irradiated with single dose of 100 R or injected with turpentine and in mice subjected to both these stress factors. The aim of this study was determination of changes in the activity of both these enzymes in the liver, kidney and spleen within 48 hours). It was found that the action of both these stress factors caused significant changes in the activity of AspAT and A1AT in the first phase of the response of the organism to stress and caused statistically significant changes of this activity on the second day of the experiment.
Acta Physiol Pol
PMID:Changes in the activity of aspartate and alanine aminotransferase caused by aseptic inflammatory reaction and ionizing radiation in the liver, kidney and spleen of mice. 724 98

The authors performed extensive partial hepatectomy in Wistar rats removing from 70% to 75% of hepatic parenchyma, and observed the subsequent healing of wounds during from 6 hours to 60 days paying particular attention to the preparation for the operation and surgical technique. Complications and methods of their prevention are described. During the experiment the pattern of the morphotic elements of the blood and the levels of GOT and GPT were checked.
Acta Physiol Pol
PMID:Physiological aspects of the partial hepatectomy in rats. 734 21

Prostaglandins appeared protective against acute experimental liver injury of different origin. Misoprostol, stable, orally active, synthetic derivative of PGE1 attenuates several functional alterations in liver mitochondria during ethanol administration. To study its possible hepatoprotective effects on ethanol-induced liver injury in rats we measured: serum activities of alanine aminotransferase (ALT), gamma-glutamyltranspeptidase (GGT) and concentrations of ammonia in blood and liver tissue. Histopathological evaluation of liver slices was also performed. Activities of both enzymes and ammonia values were elevated after intragastric ethanol administration for 60 days. Treatment for 30 days with misoprostol resulted in their decrease. This effect was not observed in the control group. Beneficial results were also obtained in histopathological evaluation of the liver tissue. These results indicate potential therapeutic effects of misoprostol on ethanol-induced liver injury in rats.
Pol J Pathol 1995
PMID:Effect of misoprostol in ethanol-induced liver injury. 749 39

Eleven kidney transplant recipients with the oral or/and throat candidiasis which occurred during the first 3 months after transplantation were studied. Fluconazole was administered orally in the dose of 50 mg each 24, 48, 72 h, according to creatinine clearance. No clinical symptoms of candidiasis on the third day of the treatment were observed. In all patients, negative mucosal cultures were noted at the 8th day after first fluconazole dose. During fluconazole was with in normal range. Furthermore, no changes in serum bilirubin alanine transaminase, lactate dehydrogenase and alkaline phosphatase activities were observed. Serum creatinine decreased during this follow-up. In the 30th day after fluconazole administration cessation the mycological evidence of Candida p. reinfection were noted in 25% of patients. Fluconazole is highly efficient and safe agent to manage the oral and throat candidiasis in renal transplant recipients.
Pol Tyg Lek
PMID:[Testing the efficacy of fluconazole in treatment of oral and throat candidiasis in patients after kidney transplantation]. 797 12

The disturbances in bilirubin level, transaminases (GOT, GPT) and alkaline phosphatase (AP) activities in serum of patients undergoing allogeneic bone marrow transplantation are discussed. Hyperbilirubinemia was considered in all, increase in transaminases activity in half of the group of 10 patients after marrow infusion. In the patients displaying hemopoietic reconstitution bilirubin levels returned to normal. In case of bone marrow graft failures or severe complications in posttransplant period the profound abnormalities in tested parameters were encountered, particularly before death. Possible causes of such disturbances in biochemical hepatic parameters are also briefly discussed.
Pol Tyg Lek
PMID:[Changes of certain biochemical parameters of liver function in patients after allogenic bone marrow transplantation]. 823 43

The aim of the investigation was to determine the effect of cryodestruction of the healthy prostate on general condition of dogs. The research was performed on 18 dogs divided into two groups: control and experimental. In the dogs from the experimental group after the laparotomy procedure the prostate was frozen in the repeated cycle using the flat cryoapplicator. The observations were carried out for 6 months. General condition of dogs was controlled, blood was examined and urine analysed. The performed determinations included the activity of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, acid phosphatase and prostatic isoenzyme of acid phosphatase. It has been observed that the cryodestruction procedures of the prostatic gland are well tolerated by dogs. During 3 weeks after the surgery the number of leucocytes in blood increased. An increased drop of the blood cells was observed for 2 weeks after the procedure. Characteristic behaviour was observed in case of the prostatic isoenzyme of acid phosphatase. Immediately after the procedure the increased activity of that enzyme was observed and 24h later its decrease which remained for about 2 weeks. Then the isoenzyme activity increased again and that increase lasted for the period of 2 months.
Arch Vet Pol 1994
PMID:Organism reaction to cryodestruction of the prostatic gland in dogs. 859 Sep 8

Nine children suffering from chronic hepatitis due to hepatitis B virus (HBV) infection were treated with recombinant IFN-alpha-2C for 16 weeks. Replication of HBV was inhibited in 5 cases while a decreased inflammatory process in the liver was attained in 3. The treatment was very well tolerated in all of the studied children. A significant increase of ALT activity in the fourth week of treatment seems to be a positive prognostic factor.
Pediatr Pol 1995 May
PMID:[Interferon alpha in the treatment of chronic hepatitis B in children]. 869 95

The aim of this study was to evaluate selected diagnostic and clinical aspects of chronic hepatitis C (CH-C) in the group of 80 patients: 68 males aged 24-65 (mean 39.8 +/- 10,5) and 12 females aged 35-66 (mean 48.7 +/- 12.6). The epidemiological data allowed to divide the basic group into 3 subgroups: patients with transfusion-associated CH-C (subgroup I: 12 males, mean age 38 +/- 6.7 and 2 females aged 40 and 46), CH-C patients with parenteral hepatitis C virus exposure-other than blood transfusion (subgroup II: 25 males, mean age 40.6 +/- 8.2 and 5 females aged 43 +/- 15.1) and sporadic cases with unknown HCV exposure (subgroup III: 31 males, mean age 38.2 +/- 11.2 and 5 females, mean age 50.5 +/- 10.3). The duration of the disease (CH-C) was calculated from the incident of acute viral hepatitis or the first signs of liver damage caused by HCV to the confirmation of CH-C by liver biopsy. The following data were analyzed: a frequency of acute viral hepatitis with jaundice at the beginning of the disease, ALT flare-ups, mean highest activities of ALP and GGT, frequency of hypergammaglobulinaemia and sings of fatty liver in ultrasonographic finding (USG). In all patients but one anti-HCV antibodies (ELISA 2nd generation test by Abbott) were detected. In 64/80 subjects antibodies to HCV antigens: 5-1-1, C 100-3, C 33c and C 22 were determined by RIBA-2 test (Ortho). In 62/80 patients HCV-RNA in serum was determined by RT PCR. Liver biopsy was performed in 71/80 patients. Other co-existent liver diseases were excluded. The similarity between 3 subgroups was shown: similar percentage of males and females, similar patients mean age and the duration of the disease. It was shown that the acute beginning of the disease with jaundice has been observed twice as frequent in subgroups I and II compared with subgroup III. The same frequency of ALT flare-ups in all subgroups was observed (25-28.6%). No differences in mean highest ALP and GGT activities in 3 subgroups were observed. It was shown, however, that hypergammaglobulinaemia was detected more frequently in subgroup III (30.5%) compared with subgroup I (7.1%) and II (16.7%). The signs of fatty liver in ultrasonographic findings were also observed more frequently in subgroup III (30.5%) than in subgroup I (14.3%) or II (16.7%). In all patient but one, in which anti-HCV antibodies by ELISA test were detected, anti-C 33c and anti-C 22 antibodies by RIBA were present. HCV-RNA in serum was detected in 77.8% subjects from subgroup I. 73.9%-from subgroup II and 66.7%-from subgroup III. In all HCV-RNA positive patients anti-HCV antibodies were detected. The evidence of chronic active hepatitis confirmed by liver biopsy was shown in 63.6%, 67.8% and 71.8% of patients from subgroup I, II and III, respectively. In no case normal liver morphology was present. Authors concluded the distressing fact of the high incidence of chronic active hepatitis in patients unaware of HCV infection, without the incident of acute hepatitis at the beginning of the disease (over 1/3 of all described subjects). The differences of the clinical course of the disease between subgroups 1 + II and subgroup III suggest two different routes of HCV infection or the presence of two different HCV mutants in Polish population. Authors emphasise the necessity of HCV gene typing in CH-C patients, which might explain the surprisingly high incidence of chronic active hepatitis in the reported group. The use of the presented data for the general practitcioner making the diagnosis of crytogenetic liver disease is also accentuated.
Pol Arch Med Wewn 1996 Apr
PMID:[Selected diagnostic and clinical aspects of chronic viral hepatitis type C]. 875 40


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