Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The findings in our clinical study was consistent with those reported by others that a temporary elevation of serum alanine aminotransferase activity is associated with epidemic hemorrhagic fever (EHF). However, the pathogenesis of the concomitant changes in liver function tests is still not clear. To clarify whether EHF virus is cytopathic or not for the liver, percutaneous liver biopsy was done in 19 patients with EHF within 3-12 days after the onset of symptoms. These liver biopsy specimens were examined with immunofluorescence assay and cell cultural technique, showing the presence of active viral replication in liver cells. Electron microscopy observation of the infected liver cells showed that ultrastructural distortions was accompanied by the existence of inclusion bodies of EHF virus in vacuoles of rough endoplasmic reticulum, endotheliocyte and microvilli. These findings strongly suggest that EHF virus may play a causative role in liver injury in patients suffering from EHF and hepatic microcirculation disturbance may be involved in the pathogenesis of EHF-related liver dysfunction as well.
Zhonghua Nei Ke Za Zhi 1992 Feb
PMID:[A study on virus localization and microcirculation in the liver in patients with epidemic hemorrhagic fever]. 135 13

We investigated the activity of LAK cells in 10 patients with chronic persistent hepatitis, 20 patients with chronic active hepatitis, 21 patients with post-hepatitic cirrhosis and 21 normal persons. The values were 36.87 +/- 7.44, 30.38 +/- 5.36, 28.84 +/- 4.95 and 44.50 +/- 4.75 respectively (P < 0.05). The LAK cell activity in patients with chronic hepatitis was lower than that of normal persons, especially in those with chronic active hepatitis and post-hepatitic cirrhosis. The causes of lower LAK cell activity in patients with chronic hepatitis were less expression of IL2 receptors on precursors of LAK cells and existing serum LAK cell inhibition factors. We further studied 9 patients with chronic hepatitis B treated with autologous LAK cell transfusions. Factors favoring a more effective result were female sex, ALT elevation after treatment, activity of LAK cells > 10%, and inhibition factor of LAK effector cells existing in serum of patients, with inhibition rate < 50%. These factors might be used as the indications in selecting cases for treatment and predicting the effect of the treatment. As the number of cases observed was rather small, further investigation is needed.
Zhonghua Nei Ke Za Zhi 1992 May
PMID:[Changes in LAK cell activity in chronic viral hepatitis and treatment with autologous LAK cell transfusion]. 147 22

All the 51 patients had history of plasma donation before onset of the illness. All had no evidences of recent infection with following viruses: HAV, HBV, CMV and EBV and were confirmed recently as hepatitis C by the Chiron C-100 EIA test. The incubation period was 35 to 90 days, with an average of 57.9 +/- 19.8 days. The ratio of icteric to anicteric was 1.0:1.55. Only a few cases had fever in the acute phase (13.7%). 36 cases showed acute onset of illness; 15 cases, however, had ALT elevation before the onset. 33 cases became chronic hepatitis after 1 year (64.7%), 14 out of the 33 cases had persistently abnormal ALT and 19 cases showed repeated elevation of ALT. The chronicity rate in 2 years was 38.6%. These results indicate that hepatitis C has the features of high chronicity rate and prolonged clinical course.
Zhonghua Nei Ke Za Zhi 1991 Mar
PMID:[Clinical and consequence study on 51 cases of hepatitis C]. 165 36

281 serum samples from Chinese healthy blood donors (HBsAg negative and ALT normal) were tested for anti-HCV antibodies with ortho-HCV ELISA test system and Abbott HCV EIA diagnostic kits. The results were further confirmed with recombinant immunoblot assay (RIBA). Our research showed that the prevalence of anti-HCV antibody in this group was 2.1% (6/281), being higher than that in other countries and regions. It indicated that great attention should be paid to HCV infection in China. The reason of dark groundback and high false positive reactivity produced by the ELISA was discussed. So, the positive reactivity produced by ELISA should be confirmed by other specific method such as RIBA. Reexamination of the 281 serum samples with HBsAg AUSRIA II showed that HBsAg was positive in 7 and HBVDNA positive in one of them.
Zhonghua Nei Ke Za Zhi 1991 Nov
PMID:[Investigation of anti-hepatitis C virus antibody in healthy blood donors in China: enzyme immunoassay and recombinant immunoblot]. 166 49

Among 203 patients with high altitude erythrocythemia (HAE), 89% had various kinds of alimentary canal symptoms, while these were present only in 31% of a control group (P less than 0.01). 49% of the HAE group had stomach, while only 8% of the control group had it. Endoscopic examination revealed 44% of the HAE group had peptic ulcer, being much higher than 6% of the control group. The ratio of gastric to duodenal ulcer in the HAE group was 2 to 1. The HAE patients had higher values of ALT, total bilirubin, LDH activity, LDH1 and LDHs, but lower values of AKP, LDH2, LDH4 and gamma-GT than the controls. The difference was, however, of no statistical significance. B mode ultrasonography showed that the incidence of hepatomegaly and splenomegaly was 24% and 11% respectively in the HAE group, while it was only 4% and 2% in the control group. HAE patients usually had symptoms of digestive system two years after the onset and the incidence at that time was 67%. With the extended course of the disease, the incidence gradually came down. The mechanism of digestive system impairment in HAE was probed and it was shown that treatment of digestive system impairment would promote the healing of HAE.
Zhonghua Nei Ke Za Zhi 1991 Aug
PMID:[Impairment of the digestive system in high altitude erythrocythemia]. 179 46

77 patients with chronic active or persistent hepatitis of type B proved by liver biopsy were divided into two groups. 39 cases were treated with Ara-A. dauricine and polysaccharide of pore umbellate as group I. 38 cases were treated with Ara-A, radix isatidis and radix salviae mitiorrhize as group II. By the end of 3 months in the course, the effective rates of ALT and AST were 68.6% and 68.4% in group I, 34.4% and 34.8% in group II. The rates of HBeAg from positive to negative were 35.9% and 39.5% in group I and II respectively. Follow up to 3 months after cessation of therapy, ALT level was normal in 55.6% of group I and 60% of group II: HBeAg was negative in 42.9% of group I and in 50% of group II. Follow up to 9 months after cessation of the treatment, ALT was normal in 56.3% of group I and in 62.5% of group II, HBeAg was negative in 37.5% of group I and in 60% of group II. These results show that dauricine and polysaccharide of pore umbellate did not strengthen the antiviral effect of Ara-A.
Zhonghua Nei Ke Za Zhi 1991 Aug
PMID:[Therapeutic effect of combined treatment with Ara-A dauricine and Chinese herbs in chronic hepatitis B infection]. 179 48

439 cases of epidemic hemorrhagic fever (EHF) in the febrile stage of the disease were randomly divided into two groups. 226 cases in therapeutic group were treated with daily intravenous drip of 60-100 ml potenlini for 3 days. Other measures of treatment in this group was just the same as those in the control group. The results showed that the duration of both the febrile stage and the hypotensive shock stage were shorter and the rate of recovering from hypotensive shock stage and oliguric stage in the therapeutic group (P less than 0.01) was higher as compared with the control group. BUN, ALT, urinary protein, white blood cells and platelets returned to normal level earlier than expected (P less than 0.01). The occurrence rate of complication and case fatality rate in therapeutic group were lower. The research showed that potenlini in the treatment of EHF has effects. But it has not remarkable effects on immune adjustment.
Zhonghua Nei Ke Za Zhi 1990 Dec
PMID:[Clinical study and immunological observation on potenlini treatment of epidemic hemorrhage fever]. 198 48

An animal model of hepatocytic necrosis was established with injection of D-galactosamine into peritoneal cavity. Examination at regular intervals after injection showed that the level of increased serum TB, ALT and GST and the degree of histological changes in the liver were less marked in PGE-treated animals (n = 34) than those in PGE-untreated animals (n = 29), suggesting that PGE has definite protective effect for experimental hepatocytic necrosis. According to severity of the condition hepatic failure was divided into early stage, typical stage and late stage. A treatment group of 55 cases received PGE1 therapy and a control group basic support therapy only. The results showed that difference of the total effective rate was not significant between the two groups, but in the early stage of hepatic failure, the effective rate in the treatment group was markedly higher than that in the control group. In addition, incidence of hepato-renal syndrome was lower in the treatment group. We are of the opinion that division of severe viral hepatitis into three stages for evaluation of therapeutic effect is rational and useful and early use of PGE1 may show certain efficacy.
Zhonghua Nei Ke Za Zhi 1991 Jan
PMID:[Protective effect of prostaglandin E on hepatocytes and its value of early treatment of severe viral hepatitis]. 203 89

The results of a prospective controlled randomized clinical study on using of autologous LAK cell reinfusion in the treatment of chronic hepatitis B (including CAH and CPH) were reported. The study was based on the criteria formulated by the National Conference of Viral Hepatitis in 1984 and patients were randomly assigned in two groups (39 cases in treated group and 25 in control group). Patients in the treated group received autologous LAK cell reinfusion treatment alone for 6 weeks and the control group 10% glucose solution intravenous drip also for 6 weeks. HBeAg seronegative rate anti-HBe seropositive rate and normalization rate of ALT after completion of the therapy were 53.8%, 28.2% and 33.3% respectively in the treated group and 20.0%, 8.0% and 4.0% respectively in the control group. The difference of parameters between the treated group and control group as described above was of statistical significance, but definite evaluation of the efficacy of this therapy can only be made after a more extended controlled randomized clinical study.
Zhonghua Nei Ke Za Zhi 1991 Jan
PMID:[Prospective study on using of autologous LAK cell reinfusion in the treatment of chronic hepatitis B]. 203 92

Using the paired method and the same observation standard, 35 pairs of patients (70 patients) suffering from chronic active hepatitis B were treated with FHST or glucose in 5 hospitals. After three months of treatment a significant decrease in ALT, TTT and a significant increase in PTA were observed in FHST group as compared with the control group (p less than 0.05-0.01). There was no significant change in HBVM in both groups. No side effect was observed during the period of treatment.
Zhonghua Nei Ke Za Zhi 1990 Jul
PMID:[Fetal hepatocellular suspension transfusion in the treatment of chronic active hepatitis B]. 228 73


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