Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 43 newborn, the enzyme activities of LDH, GOT, GLDH, and GPT in the umbilical cord blood, as well as 24 hours post partum was measured. Two groups were formed: 1. Newborn without decelerations during the course of parturition, and 2. Newborn with decelerations in the cardiotocogram. The oxygen partial pressure and the acid-base status in the umbilical cord blood, did not differ significantly in both groups. LDH, GOT and GLDH activities were significantly higher 24 hours post partum in the group of newborn with decelerations, than in the control group. The increase in GLDH by 75% was particularly remarkable. This GLDH increase seems to suggest an increased incidence of liver cell necroses, which must be interpreted as a result of the hypoxic conditions sub partu. A significant correlation between the magnitude of the deceleration areas and the extent of GLDH activities can be established. The correlation between duration of parturition and GLDH activity is likewise significant.
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PMID:[Enzyme values in the serum of newborn blood in relation to the course of parturition (author's transl)]. 64 66

Correlation between pyruvate and lactate contents as well as between enzymes participating in turnover of the substrates (pyruvate- and lactate dehydrogenases, alanine aminotransferase, pyruvate kinase) were studied in rat liver tissue simultaneously with tumor growth and intensive thiaminotherapy. Thiamine, administered into rats carrying carcinosarcoma Woker-256 at a daily dose 12.5 mg/kg body weight, exhibited the normalizing effect on activity of enzymes studied, on quantitative content of LDH isoenzymes and on content of lactate in blood and of pyruvate in liver tissue. Possible effect of thiamine on pyruvate metabolism in tumoral impairment is discussed.
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PMID:[Thiamine and pyruvate metabolism in tumor-bearing rats]. 66 48

3 cm of the common bile duct was removed in 19 dogs and the defect was bridged by an autologous vein. The interposition of a vein graft was performed with a double end-to-end anastomosis. In four cases a T-drain was additionally placed into the transplant. GOT, GPT, LDH, AP and bilirubin were tested in regular intervals. The patency of the transplant was proved by radiography with dogs which survived longer than 6 weeks. 5 dogs died within the first 4 weeks, 4 were killed after 2 months, because of incrustation of the T-drain for a regular percutaneous rinsing of the drainage was not possible. 10 dogs survived for 6 to 12 months. These animals showed increasing laboratory results up to two months, then the tests normalized. The function of the transplanted vein was without complication and the liver histology did not show any pathological alteration. After two months the transplanted vein was bridged by bile duct epithelium.
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PMID:[Replacement of the common bile duct by an autologous vein (author's transl)]. 68 91

In vivo irradiation of the blood followed by a local or parenteral injection with irradiated blood is a useful tool in radiotherapy. To reveal changes in the components of irradiated blood, the serum enzymes LDH, GOT and GPT were examined in the blood of healthy donors, and cancer patients. The same enzymes were determined in the blood of in vivo radiation-treated patients. It seems that with some restrictions LDH offers a possibility to be regarded as biological indicator of radiation effects. Beside enzyme determinations blood picture was taken and immunological methods were used too, to check their usefulness in the evaluation of radiotherapy.
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PMID:Changes of blood components on in vitro and in vivo irradiation in cancer therapy. 68 76

PC-904 was administered to 24 patients: urinary tract infections (7 cases), bronchitis (2 cases), pneumonia (3 cases), brain abscess (1 case), septicemia and the suspected cases (10 cases), and buttock abscess (1 case). The daily dosage varied from 60 to 223.4 mg/kg and averaged 86.9 mg/kg. The drug was administered three times a day by 1-hour drip infusion, and the duration of the treatment averaged 11 days. Clinical results were obtained as excellent responses in 5 cases, good in 13, poor in 4, and unknown in 2, giving 75% of the clinical effectiveness. Bacteriological responses were excellent in 7, good in 2, poor in 2, and unknown in 13, and the overall effectiveness was evaluated as excellent in 2, good in 17, and unknown in 5. Antibacterial activities against clinically isolated bacteria were examined. MIC values of PC-904 were over 100 mg/ml 1 strain of E. coli and 2 strains of Klebsiella, however excellent sensitivities were observed in 3 strains of Ps. aeruginosa and MIC values varied 1.56 to 3.12 microgram/ml at 10(8) of inoculum size and 0.78 to 1.56 microgram/ml at 10(8). As to side effects, diarrhea was observed in 1 case, rash in 2, lowering ob blood pressure in 2, elevation of GOT in 1, and elevation of LDH in 2. Abnormal elevations of GOT (10 cases), GPT (5 cases), A1-P (1 case), LDH (7 cases), and BUN (1 case) were noticed in other patients, but it was considered to be due to underlying diseases.
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PMID:[Clinical studies of PC-904 in pediatrics (author's transl)]. 69 Dec 66

In order to study the role of autoimmune processes in the origin of changes occurring during prolonged bed rest, 9 young male test subjects were examined during 30-day and 21--49 day bed rest experiments and recovery periods. No antibodies to antigens of the heart, liver, and kidneys were found. Ten out of 21 test subjects at the end of bed rest and 12 test subjects during recovery showed a high titer of the circulating cardiac antigen. Electro-, mechano, and polycardiographic stadies demonstrated that the subjects with the circulating cardiac antigen displayed more marked changes in the ECG T-wave and the contractile function of the myocardium. These changes were accompanied by activation of the enzymes ALT, ACT and LDH.
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PMID:[Clinical immunological observations of persons in a period of prolonged hypokinesia and the readaptation thereafter]. 69 70

210 male patients hospitalized for cardiac rehabilitation have been studied. As a result of age matching the sample was reduced to 190 patients: 72 patients with myocardial infarction, 90 patients with functional cardiovascular diseases, and 28 patients with angina pectoris. At the beginning and at the end of the 4 to 6 week rehabilitation program total lipids, cholesterol, triglycerides, phosphatides, GOT, GPT, LDH, HBDH, cholinesterase, aldolase, blood sugar, creatinine, electrolytes, hemoglobin, erythrocytes, leukozytes, and catecholamines were measured. In addition to the statistical comparison of the three groups and their specific change patterns, effects of body weight reduction and improvement of physical fitness were analyzed. The decrease of lipids is especially associated with weight reduction, whereas the decrease of enzyme activity and electrolyte concentration is accompanied as well with weight reduction as with the improvement of physical fitness.
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PMID:[Biochemical measures in cardiac patients: an analysis of change during rehabilitation (author's transl)]. 69 75

After ingestion of wild boar meat 58 patients developed typical clinical signs and symptoms of trichinosis. All patients had marked blood eosinophilia. In 45% of the patients GOT and GPT and in 62% HBDH were moderately increased, while in 76% LDH and in 86% creatine-kinase showed abnormally high values. CK-MB was increased in three patients. 92% of muscle biopsies showed typical morphological changes in skeletal muscles. Latexagglutination, complement-fixation and agar-gel diffusion tests were not reliable. In most of the examined cases clinical symptoms and histological results correlated well with the indirect haemagglutination test, the microprecipitation test with living larvae of Trichinella spiralis and evidence of specific antibodies (IgG, IgM, IgE) by indirect immunofluorescence and the ELISA technique. 25 patients were treated with thiabendazole (Minzolum), 19 of them successfully.
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PMID:[Trichinosis: epidemiology, clinical features and diagnosis (author's transl)]. 69 65

In 342 patients undergoing open heart surgery we determined the serum enzyme levels of GOT, GPT, LDH, alpha-HBDH, LAP, CK and CK-MB from the beginning of the operation up to the 14 th postoperative day. There was an elevation of serum enzymes depending on the type of operation, the duration of extracorporal circulation and the postoperative course. A pattern of enzyme changes for uncomplicated cases is described. The investigations demonstrate a statistically significant correlation between the elevation of "liver specific enzymes" and right heart failure on one hand and of "heart specific enzymes" and myocardial ischemia on the other hand. It is concluded that only repeated determinations beginning with the operation enable to evaluate serum enzyme levels.
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PMID:[The value of enzyme-determination after cardiac surgery (author's transl)]. 71 52

The authors examined the activity of GOT, GPT, LDH and ALD in the myometrium of ovariectomized female rats, treated with testosterone. There was a eduction in the activity of the examined enzymes in both experimental groups of animals in comparison with the group of healthy rats. The reduction of the enzymic myometrial activity was considerably more manifested in the group of ovariectomized rats than in those treated with testosterone. The results were interpreted as a consequence of the reduced synthesis of proteins enzymes due to insufficient estrogen stimulation in the myometrial tissue, sensitive to estrogen. There was a possibility also that the reduction of the enzymic synthesis was caused by energetic deficit on account of insufficient transhydrogenase activity as a result of the reduced estrogen concentrations.
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PMID:[Enzymatic activity in the uterine musculature of rats after castration and testosterone treatment]. 72 26


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