Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.6.1.2 (
alanine aminotransferase
)
26,722
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We recently reported that depletion of
FANCM
in
ALT
cells induces replication stress mainly at their telomeres. Additionally, we found that co-depletion of
FANCM
and BLM, or
FANCM
and BRCA1 induces synthetic lethality in the
ALT
cells. Our new findings could have important implications for cancer prevention and treatment.
...
PMID:Breaking the end: Target the replication stress response at the ALT telomeres for cancer therapy. 2920 49
Break-induced replication is a specific type of DNA repair that has a co-opted role in telomere extension by telomerase-negative cancer cells. This Alternative Lengthening of Telomeres (or '
ALT
') is required for viability in approximately 10% of all carcinomas, but up to 50% of the soft-tissue derived sarcomas. In several recent studies, we and others demonstrate that expression and activity of
FANCM
, a DNA translocase protein, is essential for the viability of
ALT
-associated cancers. Here we provide a summary of how and why
FANCM
depletion leads to deletion of
ALT
-controlled cancers, predominantly through a hyper-activation of break-induced replication. We also discuss how
FANCM
can and has been targeted in cancer cell killing, including potential opportunities in
ALT
and other genetic backgrounds.
...
PMID:ALT control, delete: FANCM as an anti-cancer target in Alternative Lengthening of Telomeres. 3238 67
