Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This paper reports on oral high-dose ketoconazole treatment (3 x 400 mg/die) in 38 patients with advanced (pT3-4NXMOGIII - n = 9), metastasizing (Ml - n = 23) prostatic cancers that had been treated previously (n = 23) or untreated (n = 15). The primary response rate was 66% with 37% remissions. After 1 year, the response rate was 40% with 8% remissions and 8% progressive tumours. There was drop-out rate of 34% because of adverse experience and a very high rate of side-effects for 74%. During treatment there was a significant reduction in testosterone, cortisol and acid phosphatase blood levels. There was a transient rise in liver enzymes (gamma-GT, GOT, GPT, LDH and bilirubin) above the limit. There was no change registered in the renal parameters (BUN, creatinine) or in the calcium and phosphorus blood levels. There was no difference in the response rate between patients who had been treated previously and those with no treatment. There was also no difference in the outcome of tumours that had metastasized and those that had not.
 ...
PMID:[High dosage ketoconazole therapy in the treatment of advanced prostatic cancer]. 337 69

The aim of the study is to follow up the changes in auditory and vestibular systems, common interactions between the sensory systems and the changes in some biochemical indices after vestibular loading in drivers. Several groups of drivers of heavy freight trucks were studied, aged from 25-60 and a length of service from 5 to 30 years, according to a standard programme for otoneurological examination and application of modern otoneurological methods. The biochemical investigations were performed to 32 healthy and 19 sick drivers with vestibular disorders, prior to and post vestibular provocation. The following biochemical indices were studied: serotonin, histamine, cholinesterase activity, glucose, GOT, GPT, alkaline phosphatase, calcium, potassium, sodium, chlorides, inorganic phosphorus. The biochemical changes, associated with vestibular loading of organism were established not to be strongly manifested and coming out of the frames of the normal values, nevertheless, they are significant for a given subject and should not be neglected. The data are of importance in the vocational selection of driver-applicants, prophylaxis and treatment of those working under stress situations and extreme impacts.
 ...
PMID:[Otoneurological and biochemical research on the drivers of motor vehicles]. 349 83

Concentrations of sodium, potassium, chloride, inorganic phosphorus, total magnesium, total calcium, iron, urea, creatinine, total protein, albumin, total bilirubin, alkaline phosphatase (ALP), alanine transaminase (ALT), lactate dehydrogenase (LD), creatine kinase (CK), gamma-glutamyltransferase (GGT) and aspartate transaminase (AST) were determined in serum specimens collected from 53 free-ranging mountain reedbuck (Redunca fulvorufula) during live capture using nets. Considerable variations in the concentrations of the enzymes ALP, LDH, CK, GGT and AST were found as well as in the concentrations of creatinine, bilirubin and iron. This wide variation in results seriously questions the usefulness of similar blood investigations on heterogenous groups of mechanically restrained animals.
 ...
PMID:Blood chemical and electrolyte concentrations in the mountain reedbuck Redunca fulvorufula. 350 6

Concentrations of sodium, potassium, chloride, inorganic phosphorus, total calcium, total magnesium, albumin, total protein, cholesterol, urea, creatinine, cortisol as well as the activities of alkaline phosphatase, alanine transaminase, aspartate transaminase, gamma-glutamyltransferase, creatine kinase and lactate dehydrogenase were determined in serum specimens collected from 100 free-ranging warthogs Phacochoerus aethiopicus within five minutes after they were killed with a shotgun. Average concentrations for the following chemical constituents were found: sodium (145 mmol l-1), potassium (8.6 mmol l-1), chloride (102.5 mmol l-1), phosphorus (2.31 mmol l-1), calcium (2.93 mmol l-1), magnesium (1.23 mmol l-1), albumin (26.4 g l-1), serum proteins (62.2 g l-1), cholesterol (1.82 mmol l-1) and urea (8.74 mmol l-1). The cortisol concentrations ranged from 55-340 nmol l-1 (n = 30). Wide variations were recorded in the concentration of creatinine as well as in the activities of the various enzymes.
 ...
PMID:Blood chemical parameters in the warthog Phacochoerus aethiopicus. 350 7

Serum concentrations of total proteins, albumin, glucose, alkaline phosphatase, alanine transaminase, aspartate transaminase, gamma-glutamyltransferase, lactate dehydrogenase, creatine kinase, urea, creatinine, total calcium, ionised calcium, total magnesium, sodium chloride, potassium, phosphorus, cortisol, parathormone, 25-hydroxy-VitD3 and insulin as well as the results of haematological investigations in Cape vultures (n = 10) are presented.
 ...
PMID:Serum biochemical and haematological parameters in the Cape vulture Gyps coprotheres. 350 9

The toxic action of the carbamide preparation isoproturon-50 was followed up after oral administration at a single dose rate of 3600 mg per kg body mass. Studied were also the clinical picture, body temperature, pulse rate and respiratory excursions, appetite, general behaviour and such biochemical indices as calcium, phosphorus, magnesium, carotene, vitamin A, blood sugar, total protein, aspartate aminotransferase and alanine aminotransferase.
 ...
PMID:[Clinico-experimental research on acute isoproturon poisoning in sheep]. 361 75

Six calves were used to formulate a model of liver injury, following up the activity of the serum enzymes LAP, ALD, AP, GPT, GOT, OKT, and guanase. Studied were also the contents of blood sugar, calcium, phosphorus as well as some indices of the lipid metabolism. It was found that even with the least severe injuries of the liver there was a considerable rise of the OKT, guanase, GOT, GPT, and LAP activity. It is believed that the enzyme changes alone could serve as a specific index to detect the earliest injury of the liver.
 ...
PMID:[Changes in the activity of serum enzymes and other paraclinical indices in experimental liver damage in calves]. 361 78

A model was developed of the experimental injury of kidney parenchyma with the use of potassium bichromate with six calves. Studied was the activity of ChE, LAP, ALD, APh, GOT, GPT, OKT, and guanase as well as the level of blood sugar, calcium, and inorganic phosphorus. It was found that ALD, ChE, and LAP formed a good enzyme constellation to follow up the functional status of the kidney parenchyma. The results obtained needed further clinical processing.
 ...
PMID:[Paraclinical indices in experimental damage to the renal parenchyma]. 367 10

Partial ileal bypass (PIB) surgery is a method for the treatment of familial hypercholesterolaemia in man. Since the rabbit is frequently used as an animal model in experimental studies on PIB, we have investigated the long-term effects of this surgical procedure on the health status of rabbits. Forty-eight weeks after surgery plasma and liver cholesterol levels were decreased by about 40%. The inner diameter of the bypassed ileum was drastically reduced, unlike its length. The bypassed segment did not show clear histological abnormalities. The microflora of the caecum was similar in control and PIB rabbits. PIB did not influence liver histology. The bile of the rabbits with PIB was less lithogenic than that of control animals. Blood haemoglobin levels, haematocrit values and plasma concentrations of alkaline phosphatase, alanine aminotransferase, gamma-glutamyl transferase and lactate dehydrogenase were not changed after PIB. Plasma levels of albumin, creatinine, calcium, phosphorus, vitamin B12 and folic acid were not significantly affected by PIB. Rabbits with PIB had significantly higher plasma levels of bilirubin and zinc than control rabbits, but plasma vitamin E concentrations were significantly lower. These results may be of importance for further studies on the effects of PIB in rabbits.
 ...
PMID:Long-term effects of partial ileal bypass on the health status of rabbits. 370 23

A reference range data base containing serum chemistry and hematology values on over 3000 animals is described. Data listed include the mean, standard deviation, and 10th and 90th percentiles for each of the following parameters. Serum chemistry: sodium, potassium, chloride, calcium, inorganic phosphorus, urea nitrogen, creatinine, total bilirubin, total protein, glucose, cholesterol, triglycerides, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase (monkey only), lactate dehydrogenase (dog only), and creatine kinase (dog only). Hematology: hematocrit, hemoglobin, red blood cells, reticulocytes, mean cell volume, mean cell hemoglobin, mean cell hemoglobin percent, platelets, white blood cells, neutrophils, eosinophils, basophils, lymphocytes, monocytes, and stabs. The species included are mouse, rat, hamster, rabbit, beagle dog, and cynomolgus monkey. The use of the reference ranges in routine computerized data collection is discussed.
 ...
PMID:Reference range data base for serum chemistry and hematology values in laboratory animals. 371 84


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>