Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The objective of the paper was to assess the occurrence of congenital struma in kids in relation to the clinical and biochemical finding in their mothers. Observations involved 46 imported goats of Saanen and Alpine breeds in the course of kidding and their kids. Thyroid gland hypertrophy (39 goats) and somewhat worse or even bad state of nutrition were dominant clinical findings in pregnant goats and in goats after kidding. Abortions in the last month of pregnancy were recorded in 14 goats, and 14 goats delivered stillborn kids. Eighteen goats delivered 26 liveborn kids, but 18 out of them died within 12 to 24 hours after birth. Dead kids were hairless, they had skin edema, and very shortened thoracic as well as pelvic limbs. The thyroid gland was well visible and palpable. Surviving kids lagged behind in their growth and often suffered from bronchopneumonia as an additional disease. Iodine concentration in the blood serum of goats (5.58 +/- 2.14 mumol/l) was significantly lower (P < 0.01) in comparison with kids (133.4 +/- 15.61 mumol/l). This state was characterized by adequate T3 and T4 concentrations in the blood serum of goats (1.78 +/- 0.59 and 4.53 +/- 4.44 nmol/l, resp.) and of kids (4.66 +/- 2.26 and 182.93 +/- 2.59 nmol/l, resp.). Iodine content in the thyroid gland of the seven kids that died was 1.86 +/- 0.96 mg/kg fresh tissue. Examination of indicators of the internal environment in the blood serum showed alternate statistical differences (P < 0.01) between adult goats and their kids in erythrocyte counts, hemoglobin, hematocrit value, leucocyte counts, activities of aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, alkaline phosphatase, concentrations of total protein, albumin, total immunoglobulins, total lipids, cholesterol, phosphorus, copper, iron and zinc, while the explicit relation to disorders of iodine metabolism and thyroid hormones was not confirmed. The average content of iodine in the examined samples of soil (14.67 mg/kg) and alfalfa hay (0.1 mg/kg) demonstrated that primary deficiency of iodine in goats was the cause of congenital struma in kids.
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PMID:[Iodine deficiency in goats as a cause of congenital goiter in kids]. 869 66

Concentrations of the enzymes alanine aminotransferase (ALT) and alkaline phosphatase (AP) were determined in blood samples from 626 randomly selected clinically healthy dobermann. ALT levels greater than three times the normal upper value were detected in 55 dogs. These dogs were selected for further investigation; the owners of 23 of the dogs allowed a liver biopsy to be performed. Histopathological examination revealed various degrees of hepatitis and excessive amounts of copper in 21 of the dogs. These cases, referred to as subclinical dobermann hepatitis (DH), were selected for a follow-up investigation in which the clinical signs and serum parameters (ALT, AP and bilirubin) were studied for a period of three to 48 months. Serum parameters of those with subclinical DH were compared with blood samples collected from 22 dogs with clinical DH. Individual dogs showed great variation in the levels of ALT and AP between consecutive serum samples. These enzyme levels never, however, fell to the normal range. During the subclinical stage no statistically significant (P > 0.05) change occurred in the concentrations of ALT or AP. When dogs with subclinical DH were compared with dogs with clinical DH, there was no statistically significant (P > 0.05) difference in ALT levels, whereas AP concentrations were significantly (P < 0.001) higher among clinically affected dogs. Elevated levels of bilirubin were detected almost exclusively in dogs with clinical DH. After the onset of clinical signs there was a decrease in the ALT levels and an increase in AP concentrations as the disease progressed, but the changes were not statistically significant (P > 0.05).
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PMID:Subclinical versus clinical hepatitis in the dobermann: evaluation of changes in blood parameters. 891 40

Clinical pattern and dynamics of some biochemical indicators were observed in six four-year lambing ewes of the Improved Wallachian breed in the course of 32-day administration of magnesite fly ash. A daily dose of the tested fly ash with the content of 305,000 mg/kg magnesium amounted to 500 mg/kg live weight of sheep. The intake of concentrate mixture with magnesium content in the test sheep decreased by a third between the 12th and 20th day, by another half between the 20th and 26th day and the intake was minimum to nil during the last seven days of the trial. The decrease in the intake of concentrate mixture was accompanied by increased water consumption and by gradual inappetence for hay. Shaped droppings started to change their consistency to slurry consistency from the 12th day of observation. Thinner to watery consistency of excrements appeared in all sheep between the 15th and 20th day and diarrheas persisted in all animals until the end of the trial. The indicators of hematological profile did not show an undoubted relationship to the administration of tested magnesium, and the variations in the particular indicators observed during the trial were within the physiological range. Serum enzymes showed a significant increase against the starting values only in the concentration of alanine aminotransferase on day 20 and day 26 (p < 0.05 and/or p < 0.001). An increase in the proteosynthetic activity of hepatocytes signalled a statistically significant increase in total proteins (p < 0.05), total immunoglobulins (p < 0.05) and an insignificant increase in albumin content. Out of the analyzed mineral elements, magnesium content showed the most significant relationship to administration of industrial pollutants as its significant increase in blood serum, urine and droppings was observable since day 20 (p < 0.05, p < 0.01 and p < 0.001, respectively). The dynamics of calcium, phosphorus, potassium, sodium, iron, copper, zinc, molybdenum, arsenic and cadmium concentrations showed different patterns in the blood serum, droppings and urine of sheep in the course of magnesite fly ash feeding, and the evaluation of interactions with magnesium requires further studies.
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PMID:[Dynamics of clinico-biochemical changes in sheep during magnesite loading]. 897 53

Apart from viruses, hepatotoxins, hereditary metabolic disorders, immunological factors and cholestasis may cause chronic hepatitis both clinically and histologically. As far as the etiology is concerned, a complete history can be very helpful. The clinical examination, however, is rarely diagnostic. Nevertheless, some clinical signs (e.g. ascites, splenomegaly, spider naevi) are suggestive of cirrhosis. The activities of gammaglutamyl transferase and ALT in the serum are augmented in most of the patients with chronic hepatitis independent of its etiology. Electrophoresis reveals disturbance of serum albumin and globulin ratios. "Basic' laboratory tests are supplemented by carefully selected additional investigations (e.g. immunological tests) according to the history and clinical data of the individual patient. Retrograde cholangiography is diagnostic in the majority of patients suffering from primary-sclerosing cholangitis. Liver histology, best obtained during laparoscopy, allows classification (and prognosis) of the underlying liver disease in many patients. Results of iron and copper determination in liver tissue are diagnostic in cases of congenital liver disease (hemochromatosis, M. Wilson).
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PMID:[Current diagnosis of chronic nonviral hepatitis]. 898 77

In order to evaluate the pathogenetic role of iron in Porphyria cutanea tarda (PCT), the metabolism of iron was studied in 440 patient with PCT and associated chronic liver disease (CLD) and in 91 nonporphyric CLD patients (used as a control group). The parameters considered were the following: serum iron, ferritin, Total Iron Binding Capacity (TIBC) and percent saturation of transferrin. The statistical analysis showed that the differences between the means, in the two groups, were not significant in any of the parameters examined. To investigate the possible relationships between iron metabolism and other chemico-clinical parameters concerning the porphyric disease, the associated hepatic disease and hemometry, we studied the correlations between iron parameters and total urinary and serum porphyrins, serum copper, serum albumin, hemoglobin, red blood cells, ALT, AST, CHE and GLDH. This investigation was only possible in the last 99 cases. In addition to the obvious correlations between the parameters concerning iron metabolism, the highly significant (p < 0.001) correlation between ferritin and enzyme activities which indicate cytolysis (ALT, AST, GLDH) is extremely interesting. The results seem to point to the tentative conclusion that the alterations of iron metabolism are more related to the hepatocellular necrosis than to the metabolism of porphyrins.
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PMID:Iron and porphyria cutanea tarda. 907 91

Experimental liver cirrhosis was produced by administration of thioacetamide. Cirrhotic animals were divided into two groups: one group was given zinc sulphate and the second kept as cirrhotic control. Zinc-treated animals showed a restoration of normal hepatic and plasma zinc and copper levels. Similarly, plasma levels of aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl aminotransferase, and total bilirubin decreased significantly. Light microscopic studies showed that most of the hepatocytes appeared normal in zinc-treated as compared with untreated cirrhotic animals. The amount of fibrin, reticulin, and collagen, which was high in the cirrhotic livers, decreased following zinc treatment. Staining with periodic acid Schiff's reagent showed the ability of hepatocytes to store glycogen after zinc treatment. These results revealed that zinc may have some beneficial effect in the treatment of liver cirrhosis.
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PMID:Zinc and liver cirrhosis: biochemical and histopathologic assessment. 913 80

The possible relation of the increase in the concentration of copper (Cu) in the bloodstream with the increased supply of Cu to ceruloplasmin in the liver was examined in relation to the onset of jaundice in Long-Evans rats with a cinnamon-like coat color (LEC rats), an animal model of Wilson disease. The Cu concentration in serum and that in liver, and then that in kidneys of LEC rats were correlated, and then the relationship between the Cu concentration in serum and the malondialdehyde (MDA) concentration in the liver, a marker for lipid peroxidation, and also the activities of alanine aminotransferase and lactate dehydrogenase, marker enzymes for liver damage, were examined. An increase in the Cu concentration in liver induced significant increases in the Cu concentrations in serum and kidneys, and their relationship was different before and after the onset of jaundice, as reflected by the concentration of Cu in serum (lower than 1.5 and higher than 2.7 micrograms/ml, respectively). The relationship between the MDA concentration in liver and the Cu concentration in serum showed a characteristic change between before and after the onset of jaundice. The marker enzymes for liver damage increased significantly with age, and showed distinct responses at the Cu concentration of 1.5-2.7 micrograms/ml in serum. The results suggest that the Cu concentration in plasma reflects the on-going biological and toxicological actions of non-MT-bound Cu in the livers of LEC rats.
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PMID:Copper in plasma reflects its status and subsequent toxicity in the liver of LEC rats. 948 27

An attempt was made to study the effect of taurine on the toxicity of copper in male Wistar rats. The rats were divided into eight groups and fed different diets with or without supplement of 5% taurine and 150-600 ppm copper for 2 months. It was found that the levels of copper and malondialdehyde (MDA) in the liver, and the activities of aspartate transaminase (AST) and alanine transaminase (ALT) in the plasma of rats were increased with the increasing dose of copper. However, the levels of copper and MDA, and the enzyme activities of AST and ALT in the rats fed with supplement of taurine were significantly lower than in the rats fed without supplement of taurine. The level of copper in the faeces of rats treated with taurine and copper was higher than that of rats treated with copper alone. It indicated that taurine might play a role in reducing the toxic effect of copper in rats.
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PMID:Effect of taurine on toxicity of copper in rats. 960 96

Copper sulfate is one of the most widely used algicides for the control of phytoplankton in lakes, reservoirs, and ponds. It is also used for aquatic weed control. To study the toxic effects of copper on carp (Cyprinus carpio L.), toxicity tests were carried out. Fish recovery in copper-free water was followed. After a 14-day period of exposure to five concentrations of copper sulfate (0.25-4.0 mg/L CuSO4, values ranging from approximately 5 to 70% of the 96-h LC-50) and a recovery period of the same duration, activities of the functional enzymes alkaline phosphatase (AP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the blood serum and gills were determined. Because the gills are the known target organ for copper, changes in gill structure were investigated as well. In all exposure groups for all the enzymes studied, an increase in activity was noted after 14 days. The increase in AP activity was the most pronounced in both gills and serum of carp exposed to the highest concentration tested (4 mg/L). After a "recovery" period, compared with the end of treatment, a decrease in enzyme activities was recorded, indicating eventual recovery from the Cu-induced stress (the only exception being the ALT activity in gills in the highest CuSO4 concentration). The results of biochemical analysis were confirmed by histopathology. Lesions such as epithelial hyperplasia, curling of secondary lamellae, and changes in chloride cells were observed on the gills, and their severity increased with increased toxicant concentration. Most of the changes were reversible, as exhibited by gill histopathology after the recovery period.
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PMID:Functional enzymes activity and gill histology of carp after copper sulfate exposure and recovery. 962 35

Concentrations of 34 biochemical constituents of sera were determined on 998 randomly selected urban school children and adolescents aged 8-18 years from Zagreb, Croatia. Reference intervals were obtained by using non-parametric methods to estimate 2.5 and 97.5 percentiles of distribution as upper and lower normal reference intervals, according to the IFCC recommendations. These were compared to reference intervals in the healthy adult population, aged 20-30 years from the same geographical area. Serum glucose, potassium, sodium, chloride, magnesium, iron, zinc, total serum proteins and electrophoretic fractions, and amylase, did not show age or sex differences; total serum bilirubin, total calcium, phosphate, high density lipoprotein cholesterol, total iron binding capacity, unsaturated iron binding capacity, copper, aspartate aminotransferase, alkaline phosphatase, cholinesterase, creatine kinase, and lactate dehydrogenase had higher reference intervals than the adult population. Urea, creatinine, urate, alanine aminotransferase, gamma-glutamyltransferase, total cholesterol and low density lipoprotein-cholesterol, and triglycerides had lower reference intervals than the adult population.
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PMID:Pediatric reference intervals for 34 biochemical analytes in urban school children and adolescents. 967 91


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