Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.6.1.2 (alanine aminotransferase)
26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. An automated blood serum chemistry analytical system designed for human usage was employed to establish the levels of 26 different components present in sera obtained from various experimental groups of channel catfish. 2. Comparisons of samples from feral and commercial production pond fish during warm months indicated statistically significant differences in the serum levels of sodium, CO2, urea nitrogen, direct bilirubin, cholesterol, creatinine and protein. 3. Laboratory acclimated and production pond fish exhibited differences in serum electrolytes (sodium, potassium, chloride, phosphorus), serum metabolites (urea nitrogen, creatinine, triglycerides), serum enzymes [gamma-glutamyl transferase, glutamate-oxaloacetate transaminase (GOT), lactate dehydrogenase (LDH), alkaline phosphatase, and amylase], and serum iron. 4. Seasonal (temperature?) differences in production pond fish were noted for 12 serum components including potassium, magnesium, CO2, glucose, creatinine, albumin, iron, alkaline phosphatase, and glutamate-pyruvate transaminase (GPT). 5. Comparisons of samples obtained from laboratory-acclimated fish before and 18 hours after acute handling and transport stress revealed significant differences in only three serum parameters: glucose, LDH, and creatine phosphokinase (CPK). 6. These studies suggest that "normal" values established by any method of sera analysis may be different in the same species depending on the diet, season, and presence of environmental stressors.
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PMID:Blood serum chemistry measurements of normal and acutely stressed channel catfish. 289 33

Dogs chronically infused with alpha (1-24) ACTH for 2 weeks showed continuous elevations in plasma ACTH, cortisol, and progesterone levels. Haematologic changes included immediate increases in numbers of mature neutrophils and monocytes and reduced numbers of eosinophils and lymphocytes. Haematocrits were also reduced with ACTH infusion. Whereas serum potassium levels fell in association with ACTH, serum sodium was unchanged. Activities of two serum enzymes of probable liver origin, alkaline phosphatase and alanine aminotransferase, increased gradually with ACTH treatment. Histologic examination of liver tissue revealed prominent hepatocellular vacuolisation. The trophic action of ACTH infusion was manifested by an increased adrenal gland weight and an enhanced cortisol response to a bolus ACTH injection given 1 day after the infusion ceased. Long-term infusion of ACTH resulted in haematologic, biochemical and morphologic changes resembling those observed in dogs with spontaneous pituitary-dependent hyperadrenocorticism.
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PMID:Effects of continuous alpha (1-24) ACTH infusion in the dog. 298 84

Perfluorochemical (PFC) emulsion as a perfusate of liver preservation prior to transplantation was evaluated in continuous hypothermic perfusion for 24 hours followed by orthotopic transplantation in inbred male Lewis rat. Three different contents of PFC emulsion that is, 20% (original Fluosol DA), 10% and 0% PFC solution were prepared as a perfusate. Isolated liver was stored for up to 24 hours using a continuous non-pulsatile perfusion technique of closed circuit with each perfusate. Gas content, GOT, GPT, LDH, potassium and glucose of the perfusate were measured. Oxygen consumption of perfused liver was higher in PFC emulsion than non PFC perfusate. Biochemical analysis of perfusate suggested that liver was preserved best in 10% PFC emulsion. Histological findings, especially, acid phosphatase staining, showed better result in PFC groups. One week survival rates after liver graft were 4/6 (66.7%) in 10% PFC solution, 1/6 (16.7%) in 20% and 0/6 (0%) in 0% solution. In spite of the highest oxygen consumption of perfused liver in early phase, 20% PFC emulsion did not bring the good preservation of perfused liver because of impaired circulation due to higher viscosity in low temperature. Ten percent PFC solution is considered the best in hypothermic preservation of the liver.
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PMID:[Perfluorochemical emulsion as a perfusate in 24-hour liver preservation prior to transplantation in the rat]. 305 66

The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of omeprazole are reviewed. Omeprazole, a substituted benzimidazole, has a unique site and mechanism of action because it inhibits the proton pump--i.e., hydrogen, potassium adenosine triphosphatase (H+,K+-ATPase)--and consequently blocks the final common step in the gastric acid secretory pathway. Omeprazole inhibits basal and histamine-, gastrin- and pentagastrin-stimulated gastric hydrochloric acid secretion. It produces a dose-dependent reduction in gastric acidity, gastric acid output, and gastric juice volume and has variable effects on pepsin secretion. Omeprazole has no documented effect on esophageal motility or lower esophageal sphincter pressure. Omeprazole is variably absorbed from the gastrointestinal tract, and food appears to decrease the rate, but not the extent, of drug absorption. The drug is approximately 95% bound to plasma proteins and is metabolized to inactive components that are enterohepatically or renally eliminated. Omeprazole is more effective (in most studies) than H2-receptor antagonists in treating duodenal ulcer, at least as effective in treating benign gastric ulcer, and more effective in treating reflux esophagitis. Omeprazole has been used successfully in patients with Zollinger-Ellison syndrome refractory to treatment with H2-receptor antagonists. Gastrointestinal complaints (nausea and diarrhea) are the most commonly reported adverse effects associated with omeprazole therapy. The most frequently reported laboratory abnormality occurring with omeprazole use is elevation of serum aspartate aminotransferase and alanine aminotransferase concentrations. Omeprazole will serve a valuable role in the management of gastrointestinal tract ulcers and hypersecretory conditions.
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PMID:Therapeutic evaluation of omeprazole. 306 85

Examinations were performed of 31 fattened pigs suffering from papular dermatitis (PD) and 33 fattened pigs without dermal changes (C) coming from the D. large pig-fattening farm and the production breeding herd of pigs. The weight of the pigs was from 95 to 105 kg. Both farms are sited in a mining area (intensive lignite extraction). The PD pigs, compared with the controls (C), had less total protein, cholesterol and calcium in their blood serum and increased concentrations of thyroxine (T4), non-esterified fatty acids (NEFA), vitamins A and E, inorganic phosphorus and potassium, and the higher alanine aminotransferase (ALT) activity. The PD pigs also had an increased leucocyte count in blood. In their peripheral lymphocytes the PD pigs had a significantly higher number of aberrant cells, 3.9 times higher number of chromosome breaks, slightly increased rate of sister chromatid exchanges, but half the number of chromosome exchanges of the C pigs. No differences between PD pigs and the controls were recorded in the response of the T-lymphocytes of peripheral blood to non-specific phytohaemagglutinin stimulation; neither were there any substantial differences in the concentration of serum immunoglobulins of the IgG, IgM and IgA classes. The PD and C pigs of both herds (the D. and M. farms) had low concentrations of all three serum immunoglobulins. The higher occurrence of PD in the D. herd, compared with the M. farm, is associated with a greater reduction of serum immunoglobulins (IgM by 38%, IgA by 25%, IgG by 15%).
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PMID:[Biochemical, hematologic, immunologic and cytogenetic study of papillary dermatitis in fattened pigs]. 309 11

We report the biochemical results in 90 women presenting to an eating disorders clinic: 61 who had bulimia, 22 with anorexia nervosa and seven unclassified. The results were compared with 30 control women. The group of women with an eating disorder had significantly higher concentrations of total CO2, calcium, AST, ALT, ALP, albumin and cholesterol and significantly lower concentrations of potassium, chloride and phosphate in the plasma. The elevated calcium could be accounted for in part by an increase in total CO2 and an increase in albumin. Hypokalaemia was strongly associated with self-induced vomiting and laxative abuse. Biochemical abnormalities occurred in both forms of eating disorders; however, hypercholesterolaemia was more common in anorexia nervosa and abnormal liver enzymes were more common in bulimia.
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PMID:Biochemical abnormalities in anorexia nervosa and bulimia. 310 18

Blood analyses were performed concerning glucose, uric acid, potassium, total protein, s-GOT, S-GPT, total cholesterol, HDL-, LDL-cholesterol, triglycerides, iron, ferritine, iron binding capacity (IBC), hemoglobin, thiamine, riboflavin, ascorbic acid. Significant changes with regard to improving blood levels at the end of period L, compared with the initial position, could be registrated for the following parameters: uric acid, s-GPT, HDL-, VLDL-cholesterol, triglycerides, IBC, thiamine, ascorbic acid. In both periods, the food volumes actually eaten served basically for the comparison of clinical-chemical parameters. Only a few subjects with inconvenient blood levels had an inadequate intake of the nutrient that was to be correlated with a blood parameter. On the other hand, every blood parameter showed subjects with levels above the average of the group, but averaging, at the same time, far beyond the group's nutrient supply.
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PMID:[Effect of an egg-milk-vegetarian diet on nutritional and blood status. II. Findings of a study on circulation, blood status; discussion]. 320 15

Nine male minipigs Pitman Moore have been studied from weaning (To) and during 6 months and the following constituents have been measured: albumin, amylase, bilirubin, calcium, CK, cholesterol, creatinine, copper, iron, GGT, glucose, LDH, magnesium, PAL, phospholipids, potassium, proteins, sodium, ALT, ASP, triglycerides, urea, zinc. These animals were fed a standardized diet. At 6 months of age their weight increased progressively to 12 kg. Several factors of variation have been studied; time of blood sampling age of animals. We obtained the following results: values of bilirubin, CK and TGO were always lower at 8 a.m. than 12 a.m. and 6 p.m. The effects of age were variable. They are no variation in the values of only 4 parameters (calcium, sodium, potassium and triglycerides), while the others constituents were increased or decreased. Reference values for 21 blood parameters in Pitman Moore minipigs are described.
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PMID:[Reference values of chemical constituents and plasma enzymes in minipigs]. 332 15

Thirty-two men have taken gossypol acetic acid for long periods (6-10 years). The users had side effects during the entire course. Serum glutamate-pyruvate transaminase (SGPT) was increased in 3 cases and persisted for more than a year. There was a downward trend in plasma potassium level during the loading phase. But, hypokalaemic paralysis did not occur. Results of semen analysis showed that the shorter the duration of gossypol administration, the higher the recovery rate. The positive rate of Et formation of peripheral blood lymphocytes was remarkably decreased. After cessation of gossypol for 6-12 months, Et formation of the group stopping drug showed a recovering trend, but had not recovered to normal. The IgG level in the serum of treatment group was decreased, but was still within normal range.
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PMID:Clinical safety of long-term administration of gossypol in 32 cases. 337 Sep 87

Chemical parameters comprising urea and creatinine nitrogen, cations (Na+, K+, and Ca2+), chloride, phosphorus, protein, cholesterol and enzymes, aminotransferases, alkaline and prostatic acid phosphatases, gamma-glutamyltransferase, creatine kinase, and lactate dehydrogenase were ascertained for semen from groups A (vasectomized), B (oligospermic), and C (normospermic) men, 19 to 55 years of age. Of the parameters, the vasectomized group underwent definite depressions in potassium ion, alkaline phosphatase, aspartate aminotransferase, gamma-glutamyltransferase, and lactate dehydrogenase as compared with the normospermic group; the last three enzymes and, possibly, the urea-creatinine ratio were decreased for the oligospermic group vs. the normospermic men. In the comparison of groups A and B, only the decrements in alanine aminotransferase and lactate dehydrogenase were statistically significant. In corroboration of past reports, CK-BB comprised the main isoenzyme of semen creatine kinase.
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PMID:Enzymatic and electrolytic profiles of human semen. 337 44


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