Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.6.1.2 (alanine aminotransferase)
26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We looked for variables that could serve as indexes of alcohol consumption. We tested iron, gamma-glutamyltransferase, mean erythrocyte volume, mean erythrocyte hemoglobin concentration, urea, uric acid, and alanine aminotransferase, among others, in an unselected population of men, and by principal components analysis we singled out the correlation between the two enzymes and the two hematologic values. On the other hand, calculation of the coefficients of correlation between the total amount of alcohol consumed and the 10 variables studied, together with multiple regression analysis, showed that the three variables that correlated most significantly with alcohol consumption were gamma-glutamyltransferase, mean erythrocyte volume, and the use of tobacco. Critical evaluation of the results leads us to conclude that still more discriminative biological indices msut be sought and that the use of psychosocial data is also desirable.
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PMID:Relations between reported alcohol consumption and certain biological variables in an "unselected" population. 3 2

The following blood indices were determined in the blood of 34 pregnant sows of the Large White breed under standard feeding conditions: haemoglobin, haematocrit, leucocytes, and--in the blood serum, --total protein, glucose, urea, bilirubin, cholesterol, enzyme activity (AP, GOT, GPT, GGTP) and mineral concentrations (Ca, P--inorg., Mg, Na, K, Fe, Cu, Zn, Mn). The blood was sampled in the first and third pregnancy at an average live weight of 165.12 and 197.36 kg, at an average age of 318 and 630 days and at an about the same average length of pregnancy in the time of both samplings (59 days). In younger, still growing gilts (first pregnancy) a significantly (P less than 0.05) lower content of total protein, magnesium, iron and copper was revealed, as compared with adult sows. The content of glucose, calcium, potassium and manganese in the blood serum of the gilts was significantly (P less than 0.05) higher than in sows in their third pregnancy. The adult sows showed a significantly (P less than 0.05) lowered activity of alkaline phosphatase and gamma-glutamyl transpeptidase, as distinct from gilts.
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PMID:[The effect of pregnancy order on various biochemical and hematological values in sows]. 10 42

After the second and fourth parturition of piglets, ten clinically healthy sows, weaned on the second day of life, were subjected to examination two to three days before heat, during heat (defined by typical changes on the outer genitals and immobilization in the presence of a boar) and two days after insemination. During the morning hours, four hours after the last feeding, blood was taken from V. cava cranialis. Seventeen parameters were determined in whole blood and in the blood serum. In the period of oestrus, compared with the period two to three days before this period and two days after insemination, a marked increase was observed in the concentration of the serum levels of 11-hydroxycorticosteroids, iron, and in the activity of alanine aminotransferase. The activity of aspartate aminotransferase was increased in heat only in comparison with the period of the two days after insemination. The concentration of haemaglobin in whole blood was significantly increased in comparison with the period before oestrus and after insemination. Further, in the heat period -- as compared with the time before it -- a considerable drop was observed in the content of inorganic phosphorus and vitamin A. The possible mechanism of the occurrence of other changes is discussed.
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PMID:[Biochemical and hematological changes in sows during estrus]. 11 95

Normal values for a number of blood components of grivet monkeys are reported. Haematological data and values for glucose, cholesterol and urea are similar to those of rhesus monkeys. Activities of alkaline phosphatase (1526 U/l), glutamine oxaloacetate transaminase (30.9 U/l), glutamine pyruvate transaminase (13.7 U/l), lactate dehydrogenase (629 U/l), alpha-hydroxybutyrate dehydrogenase (175 U/l), creatine phosphokinase (227 U/l), gamma-glutamyl transpeptidase (38.7 U/l) and sorbitol dehydrogenase (14.2 U/l), and levels of lysozyme (178 mg/dl), zinc (162 microgram/dl), copper (81.3 microgram/dl) and iron (296.5 microgram/dl) have not previously been reported for this animal. Values for serum amino acids, proteins, electrolytes, triglycerides and creatinine are compared with those of other primates.
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PMID:Normal values for some whole blood and serum components of grivet monkeys (Cercopithecus aethiops). 11 24

One hundred and sixteen colony control dogs (purebred beagles) ranging in age from 56 to 4868 days at the time of sampling, were tested at various intervals over a 10-year period to determine the normal values of several serum constituents. The effects of sex and family line were also noted. With increasing age, serum glutamic-pyruvic transaminase, total protein, and cholesterol increased, whereas glucose, serum glutamic-oxalacetic transaminase, creatine phosphokinase, iron, alkaline phosphatase, and albumin decreased. Females had significantly higher levles of urea nitrogen, iron, and cholesterol than males. Males had significantly higher serum glutamic-pyruvic transaminase levels. The rate of increase in serum cholesterol with age was greater in males than in females. Males showed no age related changes in levels of urea nitrogen or iron, while the females showed decreasing levels. Significant differences in total protein and albumin were noted in dogs belonging to different family.
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PMID:Serum chemistry values of normal dogs (beagles): associations with age, sex, and family line. 59 88

In 51 cases of liver cirrhosis an increased amount of free protoporphyrins in matured erythrocytes was obvious in 22 cases (43%). In 29 cases (57) the amount of EPP rranged at the normal rate. No relationship was found neither to the blood level of bilirubin, iron, protein or of GOT and GPT nor to different histologic findings in liver biopsy slices. The only relation seemed to be as to the amount of fat deposits in hepatocytes. Cases with a high amount of fat had an increased amount of EPP too. Two groups of liver cirrhosis have been separated: one group with EPP amounts above 27/10(11) and another group with EPP amounts below 27/10(11) e., thus ranging within normal rates. Therefore a partial impairment of function is supposed to be and discussed in regard to steroid metabolism.
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PMID:Alteration of haem synthesis in cirrhosis of the liver. 65 43

Nutritional status of vitamin B6 was investigated in two groups of 102 hospitalized aged. Vitamin B6 intake was estimated. Erythrocyte glutamic-pyruvic transaminase stimulation in vitro with pyridoxal phosphate and SGOT were studied as the biochemical criteria of vitamin B6 status: 18.6% of the subjects consumed less than 0.66 mg of vitamin B6 per day; 28.4% showed a percentage stimulation in vitro with pyridoxal phosphate of more than 15%. There was no significant correlation between basal erythrocyte glutamic-pyruvic transaminase activity and dietary protein, dietary vitamin B6 dietary vitamin B6/100 g of protein, SGOT, hemoglobin, mean corpuscular volume, and iron. All the biochemical parameters used for evaluating vitamin B6 status appeared higher in females, but no statistical difference between male and female groups was noted. Only SGOT levels of female subjects reflected their vitamin B6 status. A large individual variation of vitamin B6 requirement was indicated in both groups studied. Supplements with 2.5 mg of vitamin B6 to deficient subjects caused an increase in transaminase levels, though females showed a higher response. A higher recommended allowance of vitamin B6 for the aged male and female subjects was considered desirable.
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PMID:Vitamin B6 status of the hospitalized aged. 67 75

Only 11% out of 215 patients with resection of the stomach had a normal liver if the term of the resection was not longer ago than 30 years. Contrarily the deposition of fat became less frequent with increasing distance from the operation term while deposition of iron (siderin) was demonstrable nearly equaly in all groups. Age and sex did not influence the behaviour of the liver after resection of the stomach. The information value by blood transaminase activity (GOT/GPT) decreases with the distance of time from the resection term. Alcoholics (n = 20) had less shares of post resection liver harms than non-alcoholics. Thus alcohol seems to be not a bigger risk for resectioned as for people with normal stomach. Repeated liver biopsies after different intervals of time pointed out that a change for the worse happened more often with increasing distance to the resection term. Therefore resected patients should be examined regularly, including liver biopsy, as to discover in time a growing up liver damage. After resection of the stomach discovered liver diseases refer to a damage caused by that stomach disease which induced the operation.
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PMID:[Liver damage after resection of the stomach: evaluation of 215 cases (author's transl)]. 84 Jan 23

Changes in serum chemistry values as a result of incomplete removal of erythrocytes and in vitro hemolysis during the preparative process have been studied. Two levels of contamination, corresponding to removal of 99% and 99.9% of the erythrocytes, were used to examine the effects of both hemolyzed and intact cells. Forty chemical procedures and methods were considered. Serum LDH values were most strongly affected by hemolyzed erythrocytes. Potassium, creatine phosphokinase, aspartate aminotransferase, alanine aminotransferase, and iron showed smaller but significant effects due to the presence of 1% hemolyzed cells, with lesser effects observed at the 0.1% level. The presence of non-hemolyzed cells at either level did not significantly alter chemistry results.
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PMID:The effects of 0.1 and 1.0 per cent erythrocytes and hemolysis on serum chemistry values. 97 Mar 64

Fifteen women with pseudo-LE syndrome were studied. The dissease is characterized by recurrent attacks of fever, myalgia, arthralgia, visceral manifestations (pericarditis, myocarditis, pleurisy, pleural effusion and lung involvement). A prominent feature was an abnormal liver function with elevated GOT and GPT levels in serum, and impaired bromsuophalein elimination. The incidence of varicosities and thrombophlebitis was markedly increased. There was a correlation between complement-fixing antimitochondrial antibody (AMA) titres and the degree of activity of the disease. A reverse correlation was observed between antimitochondrial antibody titres and the absolute lymphocyte count in peripheral blood. In all instances the antimitochondrial antibodies were of polyclonal origin, belonging mainly to immunoglobulin class IgG and, in a few patients, IgM, IgA, or IgD. AMA titres, lymphocyte counts in peripheral blood, sedimentation rate, serum iron level and alpha1- and alpha2-globulins proved to be valuable in following the course of the disease. Other values (C-reactive protein, alpha1-acid glycoprotein, immunoglobulin and beta1c-globulin in serum) were not helpful.
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PMID:[Clinical and serological aspects of the pseudo-LE syndrome (author's transl)]. 112 30


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