Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.6.1.2 (
alanine aminotransferase
)
26,722
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aspoxicillin
(
ASPC
), a new penicillin for injection, was evaluated for its efficacy and safety in 29 children with bacterial infection (Table 1), and the following results were obtained. MICs of
ASPC
to 26 strains of isolated organisms are shown in Table 2. MICs to 4 out of 13 strains of H. influenzae were higher than 6.25 micrograms/ml. MICs to 5 strains of S. pneumoniae were lower than 0.78 microgram/ml and 1 out of 3 strains of S. aureus and 1 strain of E. coli showed higher MICs than 100 micrograms/ml.
ASPC
was administered in 3 or 4 divided doses at a daily dosage ranging from 21 to 98 mg/kg by 30 minutes drip infusion or intravenous injection to 29 patients (16 cases of pneumonia, 8 cases of tonsillitis, 3 cases of bronchitis, 1 case of urinary tract infection, 1 case of impetigo) and the following clinical results were obtained: excellent; 11 cases, good; 11 cases, fair; 3 cases, poor; 1 case. The overall efficacy rate was 85% (Table 3, 4). No clinical side-effects were observed in any of the patients. Leukopenia was noted in 1 case. Slight elevation of GOT and
GPT
was noted in 2 cases, and minimal elevation of GOT was observed in other 2 cases (Table 5). These data suggest that
ASPC
is an useful new antibiotic in the treatment of children with susceptible bacterial infection and may be used as the first choice antibiotic for the treatment of respiratory tract infection in children.
...
PMID:[Clinical evaluation of aspoxicillin in children]. 385 58
Aspoxicillin
(
ASPC
), a new semisynthetic penicillin, was administered to a total of 13 children with respiratory tract and other various infections. Respiratory tract infections in 7 of 13 children were treated with
ASPC
intravenously, 64 to 144 mg/kg/day t.d.s. or q.i.d. The other 6 patients with various types of infections were also treated with the combination of
ASPC
and other antibiotics. Their clinical and laboratory data were evaluated only for adverse reactions. Concentration of
ASPC
level in serum and urine was determined after 60 minutes intravenous drip infusion of 20 mg/kg/dose of
ASPC
dissolved with the solution of solita T3 in 3 children. The half-life of
ASPC
was 0.76 to 2.31 hours and urinary excretion rate was 53.0% in first 6 hours. The effectiveness rate in respiratory tract infections was 100%. Clinical side effects were not recognized except loose stool in 1 case. The increase and decrease of platelet counts and the elevation of
GPT
were encountered 3 of 13 cases.
...
PMID:[Clinical evaluation of aspoxicillin in children]. 406 29
