Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The protective effect of pyridoxine-2-oxoglutarate (ACP) was studied on CCl4-intoxicated rats. A sensitive improvement of hepatic conditions was shown in ACP-treated rats as compared with untreated ones and rats treated with 2-oxoglutarate and pyridoxine. Serum GOT, GPT, OCT activities, composition of serum proteins, liver mitochondria respiratory control index and liver microsomes oxidizing activity were tested. The antiketotic properties of ACP were also demonstrated in Streptozotocin treated rats.
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PMID:Effect of ACP (pyridoxine-2-oxoglutarate) on CCl4 intoxication and in streptozotocin-induced ketosis in rat. 15 Jul 79

The kinship analysis of seven genetic systems in the province of Ferrara permits some considerations on the possible chronology of emergence of their polymorphisms in the area. It is proposed that, assuming neutrality of these systems, and under several restrictions, the emergence by migration of the polymorphisms in the seven systems ACP, ESD, GLO, GPT, PGD, PGM1, PGP might have had the following sequence: PGP and GLO and possibly PGD; PGM1 and GPT; ACP and ESD. All polymorphisms must be older than the beta-thalassemia polymorphism in the area.
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PMID:Kinship structures and migration in the Po Delta. 135 Jan 89

62 specimens of cystic fluid drawn back by ultrasound guided needle-aspiration in 37 males and 25 females were evaluated biochemical analysis including magnesium, calcium, phosphorus, chloride, uric acid, total protein, sugar, urea, creatinine, sodium, potassium, total cholesterol, AST, ALT, ALP, ACP, PAP, alpha-amilasys. In our study Cl, Na and sugar showed similar concentrations in the two fluids. Uric acid, and urea were more concentrated in the cystic fluid while Mg, Ca and total protein were more pronounced in the blood. The results obtained seem to indicate that simple renal cyst could originate from glomerular proximal tubulus part of the nephron as consequence of an obstructive cause.
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PMID:[Simple renal cysts, biochemical analysis of the cystic fluid, and comparison with blood parameters]. 183 Apr 3

The present study was conducted to observe the effect of platelet activating factor antagonist-WEB 2086 on the galactosamine/endotoxin (GalN/E)-induced rat liver injury. The results showed that the WEB 2086 (1, 20 or 40 mg/kg, ip) diminished significantly GaIN/E induced elevations of ALT.AST and ACP in the serum (P less than 0.01). Histological changes of the liver were also found to be improved significantly by WEB 2086 administration. Additionally, WEB 2086 decreased significantly the GaIN/E-induced increase of Malondialdehyde (MDA) and Myeloperoxidase (MPO) in the liver (P less than 0.05-0.01), and prevented the decreasing of superoxide dismutase (SOD) in the liver (P less than 0.01). The results obtained with WEB 2086 confirm that platelet activating factor (PAF) has an important role in the pathophysiology of liver injury, PAF-antagonists may have protective effects on liver injury.
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PMID:[Protective effect of a platelet activating factor antagonist in experimental liver injury]. 217 27

The importance of calcium and phosphorus metabolism for the development of hypertrophic cardiomyopathies is still obscure. Therefore 52 patients with hypertrophic cardiomyopathy were subjected to detailed cardiological and laboratory examinations. Twenty-five age matched healthy subjects served as controls. The following indicators were assessed: calcium and its ionized fraction, phosphorus, chlorides and magnesium in serum and 24 h urine, as well as AST, ALT, ALP, ACP, urea, creatinine, protein electrophoresis (to check calcium values with regard to serum albumins), endogenous creatinine clearance, Palmer's chloride phosphate index and Nordin's index. In addition to tubular phosphate reabsorption, the renal phosphate threshold was assessed and finally the parathormone blood level by the RIA method. In patients with hypertrophic cardiomyopathy a significant increase of the parathormone level was found--in a total of seven patients with advanced myocardial hypertrophy (more than 30 mm). There were no significant differences in the remaining parameters. It may thus be admitted that in some instances the increased parathormone level may cause an increase of the already existing myocardial hypertrophy. However, in the broad spectrum of patients with hypertrophic cardiomyopathy it is not suited for explaining morphological findings.
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PMID:[Are there abnormalities of parathormone, calcium and phosphorus metabolism in hypertrophic cardiomyopathy?]. 237 75

Alkaline phosphatase (ALP, EC 3.1.3.1), acid phosphatase (ACP, EC 3.1.3.2), aspartate aminotransferase (ASAT, EC 2.6.1.1) and alanine aminotransferase (ALAT, EC 2.6.1.2) were measured in the mucosal homogenates of the duodenum, jejunum and caecum of full-fed (control), starved and refed White Rock Cockerels. Starvation caused a significant (p less than or equal to 0.05) increase in the activity of ACP in all three segments of the intestine. Subsequent re-feeding brought the activity back to the control level. In contrast ALP activity fell in the duodenum during starvation and was partially restored by refeeding. In the jejunum and caecum the ALP activity decreased during starvation and was fully restored by re-feeding only in the caecum. ASAT activity increased (p less than or equal to 0.05) during the entire period of starvation in all three segments. Re-feeding failed to decrease the enzyme activity within 48 hours. Starvation caused a reduction (p less than or equal to 0.05) in the activity of ALAT and re-feeding did not increase the activity in the duodenum and jejunum. The caecum showed no change in the activity during fasting.
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PMID:The activities of phosphatases and aminotransferases in the epithelium of the small intestine and caecum of white rock cockerels during starvation. 255 Nov 9

Two population groups in South Korea, one from Kwangju and one from Kangreung, were studied in regard to the erythrocyte enzyme polymorphisms GPT, ACP, GLO, ESD, 6PGD, ADA, AK, PGP and subtypes of PGM1 as well as regarding the serum protein variants of C3, HP, BF, PLG, AMY and the subtypes of GC, TF and PI. The results were compared with data of the population groups from the area of Cheju Island, Taejon and Seoul. The Korean population showed a rather high degree of genetic homogeneity.
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PMID:Red cell enzyme and serum protein polymorphisms in South Korea. 261 52

A total of 332 persons from three localities in the Fiji Islands have been tested for genetic variation in 24 red cell enzyme systems and 4 serum protein systems. Polymorphic variation was present at 7 red cell enzyme loci and 1 serum protein locus. The remaining systems were invariant except for a single individual with a slow variant at the GOT1 locus and another individual with a D variant at the TF locus. The series from Nandi differed significantly from the Lau Islands for gene frequencies in GPT, ACP and ESD, Koro Island differed from the other localities at the PGD locus and from Nandi for ESD. Genetic distance analysis reveals that Lau Islands cluster with Western Samoa, Koro Island with New Caledonia (Vanuatu), with Nandi being separate.
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PMID:Red cell enzyme and serum protein gene markers in Fijians. 315 10

Two generations of a family with autosomal dominant carpal tunnel syndrome were studied for genetic linkage to 20 informative polymorphic blood markers. No linkage was demonstrated between the syndrome and the markers tested; exclusion of close linkage (lod score less than -2.0) was found for MNSs, ACP, GALT, GPT, GLO, Hp, Gc, and Pi.
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PMID:Genetic linkage analysis of the carpal tunnel syndrome. 404 79

Physical, biochemical, and cytologic properties of synovial fluid from normal equine tarsal joints were investigated. Tarsal synovial fluid was pale yellow, clear, free of flocculent material, and did not clot. Volume varied in direct proportion to individual tarsal joint size. Relative viscosity was related to volume, polymerization and quantity of hyaluronic acid, and protein concentration. Mucinous precipitate quality (hyaluronic acid polymerization) was uniformly high. Results of certain analyses of serum were compared with those of tarsal synovial fluid. Tarsal synovial fluid protein concentration was low in conjunction with a high A:G ratio. Serum: synovial fluid sugar ratio was 1.24:1. Serum ALP, ACP, LDH, GOT, and GPT activity levels were higher than their corresponding levels of activity in tarsal synovial fluid. Serum ALD activity level was slightly lower than its tarsal synovial fluid counterpart. Total erythrocyte counts ranged markedly, while total leukocyte counts were uniform and low. Lymphocytes were the predominant synovial fluid cell type.
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PMID:Characteristics of normal equine tarsal synovial fluid. 422 34


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