Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

47 cases of viral hepatitis with HBs antigenemia, who were diagnosed by peritoneoscopy and biopsy, were studied. 41 cases were males, and 6 cases were females. The onset ages were mostly in 25--29 years old. The histories of blood transfusion were found in only 4.3%. On the other hand, the families clustered with HBs antigen were found in 68%. Recidivums were often seen (76%), and yet the intervals between recidivum were short (the neighborhood of 8 months). The transaminases at the recidivums were not so high (200 units or thereabout). 20 cases whom biopsies were performed more than twice, were studied histologically. 14 cases were prognessive. 5 were stationary. 1 was improved. In all of progressive cases, sublobular hepatic necrosis was seen. But in other cases, sublobular necrosis was not seen. After this sublobular necrosis, various distortion of the lobule architecture was appeared, and some of them progressed to liver cirrhosis. As to GOT and GPT, GPT was dominant before sublobular neerosis, but GOT was liable to be dominant after sublobular necrosis. Peritoneoscopically, peculiar red spots were found on liver surfaces at the time of sublobular necrosis.
Hokkaido Igaku Zasshi 1978 Sep
PMID:[Studies on development of viral hepatitis with HBs antigenemia (author's transl)]. 74 63

Feeding a pyridoxine deficient diet, for 2 weeks after hatching, had no effect on post-hatching development of chick brain aspartate aminotransferase (L-aspartate:2-oxoglutarate aminotransferase, EC 2.6.1.1) activity or on cholesterol deposition in the brain, but significantly depressed the development of brain alanine aminotransferase (L-alanine:2-oxoglutarate aminotransferase, EC 2.5.1.2) activity. Feeding a pyridoxine deficient diet from 3 to 8 weeks of age had no effect on any of the three parameters studied.
J Nutr 1977 Sep
PMID:Pyridoxine deficiency and postnatal development of brain aspartate and alanine aminotransferase activities, and cholesterol levels in chicks. 89 57

The method for the determination of enzymic activity in turbid, lipaemic sera, which involves clearing by polyanion precipitation with heparin and magnesium chloride, was critically reviewed. In the diagnosis of diseases of the liver and pancreas, which are frequently associated with hyperlipoproteinaemia, only residual enzyme activities are measured in the cleared serum after polyanion treatment. In the measurement of glutamate dehydrogenase and in the Phadebas test for alpha-amylase, the enzymes are inactivated by treatment with heparin and magnesium chloride. On the other hand, as a result of polyanion precipitation gamma-glutamyl transferase is transferred, together with lipoproteins and chylomicrons, to the lipid-rich supernatant. Acid phosphatase also exhibits only residual activity in cleared serum. The activity of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, leucine arylamidase, cholinesterase, creatine kinase, lactate dehydrogenase, and alpha-hydroxybutyrate dehydrogenase, and the activity of alpha-amylase in the Merckotest are not affected by polyanion treatment of the serum.
J Clin Chem Clin Biochem 1977 Sep
PMID:[Enzyme diagnosis in lipaemic sera before and after polyanion precipitation with heparin and magnesium chloride (author's transl)]. 92 35

The Vitatron has been used as designed by the manufacturer under routine laboratory conditions (Broughton, P.M.G., Buttolph, M.A., Gowenlock, A.H., Neill, D.W. and Sleutelberg, R.G. (1969) J. Clin. Pathol. 22, 278). We assessed the possibilities of the AKES with regard to determination of the activities of three enzymes: alanine transaminase (AIT), aspartate transaminase (AsT) and lactate dehydrogenase (LDH) in serum. Precision, accuracy, carry over and sample-diluent contamination were evaluated. This resulted in recommendations for optimal use in terms of capacity and precision, which were supported by computations on a mathematical model for measuring results.
Clin Chim Acta 1976 Sep 20
PMID:Evaluation of the Vitatron "AKES" modification for optimal use in routine enzyme analysis. 97 29

Polyriboinosinic-polyribocytidylic acid (poly I - poly C), an interferon inducer, was administered in multiple doses of 0.3-75 mg/m2 to 26 patients with a variety of solid tumors, 9 with acute leukemia, and 2 with chronic myelogenous leukemia in blast crisis. Forty-four separate drug trials were comprised of various schedules and routes of administration. Toxic reactions included fever (in 66% of the trials), transient elevation of serum glutamic-oxaloacetic transaminase and serum glutamic-pyruvic transaminase (25%), minimal laboratory evidence of coagulation abnormalities (59%), and hypersensitivity (5%). These toxic manifestations did not relate to dose level or magnitude of interferon induction. Poly I - poly C administered iv induced low serum concentrations of interferon in 24/38 trials (63%), but the correlation between drug dose and peak interferon titer was not linear. Poly I - poly C administered iv or im was not effective as an inducer of interferon in the cerebrospinal fluid. Similarly, poly I - poly C administered im or by inhalation did not produce detectable serum levels of interferon. No patients experienced an objective tumor response to the administration of poly I - poly C, and most (76%) had progression of their disease while receiving the drug.
J Natl Cancer Inst 1976 Sep
PMID:A phase I-II trial of multiple-dose polyriboinosic-polyribocytidylic acid in patieonts with leukemia or solid tumors. 97 71

Male mice treated with nicotine hydrochloride either acutely (5 mg/kg i.p.) or subchronically (5 mg/kg i.p. daily for 3 weeks; 25 mg/liter in drinking water for 2-3 months) showed no evidence of hepatic dysfunction, as measured by serum glutamic-pyruvic transaminase or serum alkaline phosphatase activities. Neither acute nor subchronic administration modified the hepatotoxic response to a potent hepatotoxin (carbon tetrachloride), nor that of less potent hepatotoxins chloroform or 1, 1, 1-trichloroethane, nor was the cholestatic effect of alpha-naphthylisothiocyanate modified.
Arch Int Pharmacodyn Ther 1976 Sep
PMID:Hepatic function after acute of subchronic nicotine administration in untreated mice and mice treated with hepatotoxic chemicals. 99 92

Serum guanase, aspartate aminotransferase, alanine aminotransferase, creatine phosphokinase and hydroxybutyrate dehydrogenase activities were measured in 290 blood samples from 96 consecutive patients admitted to a Coronary Care Unit. Elevated serum guanase activities (greater than 2 U/l) were found in 19 patients (20%). The magnitude and frequency of these elevations did not negate the value of guanase as a "liver function test", since all cases with raised guanase also had abnormal serum alanine aminotransferase activities. This fact, together with other information in the literature, indicated that elevated serum guanase activity following myocardial infarction was consequent upon some degree of sub-clinical hepatic necrosis. Caution must be exercised when serum asparate aminotransferase is used as an index of heart muscle necrosis unless guanase or some other "liver specific" enzyme is known to be normal, or unless creatine phosphokinase or hydroxybutyrate dehydrogenase activities are elevated.
Clin Chim Acta 1975 Sep 01
PMID:Serum guanase activities after myocardial infarction. 117 93

The authors report the clinical, biochemical, histological and etiologic characteristics of 24 patients with the syndrome of benign intra-hepatic post-operative cholestasis. Jaundice appeared early in the post-operative period, from the first to the 12th post-operative day. All patients had received blood transfusions. In 23 patients, the post-operative course was complicated, chiefly by local infection or septicemia. Hyperbilirubinemia ranged from 2 to 28 mg per 100 ml and was mainly conjugated; serum alkaline phosphatase activity was normal or moderately elevated; in 3 patients, it was markedly elevated; serum glutamic-pyruvic transaminase activity was normal on 7 patients, moderatly increased in 15, and markedly increased in one. Liver histology was normal in 6 patients, and showed minimal lesions (cholestasis and slight portal inflammatory changes) in 3. Jaundice did not appear to modify the final outcome. It appears to be due both to increased production of bilirubin (as a result of blood transfusions) and to decreased excretion of bilirubin by the liver (as a result of the surgical operation and of infection).
Nouv Presse Med 1975 Sep 20
PMID:[Benign postoperative intrahepatic cholestasis]. 117 77

In the serum of 40 male and 40 female rats the following parameters were determined: Sodium, potassium, creatinine, chloride, calcium, inorganic phosphorus, glucose, urea, protein, cholesterol, bilirubin, lipids, alanine amino-transferase, alkaline phosphatase and leucine arylamidase. The analyses were carried out in the same rats both after continuous feeding, and after a 24-hour fasting periods spaced at intervals of 3- to 4-weeks. The concentration of glucose and the activities of alanine aminotransferase and alkaline phosphatase were higher after feeding than after fasting, and in most cases these differences were statistically significant. The concentration of lipids tended towards increased values. The other parameters examined were slightly or not influenced by the time of the foregoing feeding.
Z Klin Chem Klin Biochem 1975 Sep
PMID:[The influence of feeding on clinical-chemical parameters in the serum of rats (author's transl)]. 119 11

The value of screening blood donors for non-A, non-B Hepatitis using GPT as the surrogate marker has been debated for long time. Since January 1990, Japanese Red Cross Blood Centers have introduced anti-HCV screening with EIA. Approximately 1.1 percent of blood donors screened was anti-HCV positive in Kyushu district. Studies comparing with seroconversion rates showed discrepancy between anti-HCV and anti-HTLV-1 in some regions [Kagoshima: 0.9% (anti-HCV)/5.7% (anti-HTLV-1), Okinawa: 0.7%/5.2%, Nagasaki: 1.0%/3.7%]. Seropositivity of anti-HCV progressively increased with the age and GPT value in both male and female. In blood donors having history of transfusion, anti-HCV reactive rate was more than 10%. Results of Japanese Red Cross Non-A, Non-B Hepatitis Research Group show the effectiveness of implementation of anti-HCV screening to prevent posttransfusion hepatitis.
Rinsho Byori 1992 Sep
PMID:[Current status of anti-HCV screening and posttransfusion hepatitis]. 127 46


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