Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sequential therapy to regulate menstruation was administered to 30 women to determine if liver functions are disturbed by contraceptive use. 15 women aged 16-22, used a sequential preparation consisting of ethinyl estradiol and norethisterone acetate. These patients showed significant decreases in aminotransferase GPT and alkaline phosphatase in the last (gestagen) stage of treatment, and slight increases in alpha-amylase and beta-globulin throughout the therapy. In the 15 women aged 17-34 who used ethinyl estradiol and chlormadinone acetate, the ZST showed a significant increase during the therapy. No significant changes in the liver function could be shown by these tests. These preparations are recommended for treatment of disturbances of menstrual cycles; tests of liver functions during treatment are unnecessary. The length of the estrogen and estrogen-gestagen phases of the treatment should be equal to prevent hormonal imbalance.
 ...
PMID:[Liver function tests under the influence of sequential treatment using ethinyl estradiol-norethisterone acetate and ethinyl estradiol-chlormadinone acetate]. 6 69

In rats the induced enhancement of glutamic-pyruvic transaminase and leucine aminopeptidase activity in plasma to 5.2 mMol CC14/kg (per 05) is potentiated after repeated drawing of blood. The DL50 of CC14 following oral application in rats after loss of blood is reduced significant comparatively to controls and to animals with increased content of haemoglobin in blood.
 ...
PMID:[Loss of blood and carbon tetrachloride poisoning]. 6 90

Male 13-lined ground squirrels induced to emerge from hibernation resumed feeding and gained weight. The weight gain was supported by increases in the levels of glucose 6-phosphate dehydrogenase, L-alanine aminotransferase and carnitine acetyltransferase in the liver. Maturation of the testis occurred in a period of about 16 days spanning the time of induced arousal. The testes of hibernating males were characterized by higher levels of L-alanine aminotransferase, glucose 6-phosphate dehydrogenase and 3-hydroxyacyl-CoA dehydrogenase than the testes of aroused males. Hexokinase, carnitine acetyltransferase and citrate synthase levels were similar in the testes of hibernating and aroused males. 3-Hydroxyacyl-CoA dehydrogenase was more active and L-alanine aminotransferase less active in ground squirrel sperm than in rat sperm.
 ...
PMID:Changes in enzyme levels in the testis and liver of the 13-lined ground squirrel (spermophilus tridecemlineatus) at the time of arousal from hibernation. 7 Oct 81

This study was undertaken to examine the relative embryotoxicity in chick embryos of photochemically reacted and unreacted diluted automotive exhaust emissions from a system equipped with a catalytic converter. Clean air controls and H2SO4 aerosol controls equivalent in concentration to those found in the catalytic exhaust atmosphere were also studied. From day 1 through day 14 of development, continuous exposure to nonirradiated exhause resulted in decreased survival, lowered embryonic weight, a small increase in heart/body weight ratio, and altered hematocrit and serum enzyme activities (LDH and GOT). Irradiated exhaust had little effect on survival or on embryonic weight but resulted in a higher liver/body weight ratio as well as altered hematocrit and serum enzyme activities. Interactions or cumulative effects of different compositions of exhaust atmospheres may play a role in differing biological responses between unreacted and irradiated exhaust. Sulfuric acid aerosol had a minimal effect on survival and resulted in only a slight decrease in embryonic weight and serum LDH activity, with no other apparent effects. In previous studies where the catalytic converter was not used, more pronounced effects on survival, increased heart/body weigh ratio, elevated serum GPT activity, and liver discoloration were observed. Thus, the introduction of an oxidizing catalytic converter appeared to alleviate some but not all of the embryotoxic effects of automotive exhaust.
 ...
PMID:Embryotoxicity of irradiated and nonirradiated catalytic convertertreated automotive exhaust. 7 96

A comparison of the cost of laboratory-made reagents with that of commercial kits was made for three serum-enzyme estimations and three serum-hormone estimations. The cost of reagents in kit form could only be justified on economic grounds for serum aspartate transaminase, alanine transaminase, and lactic dehydrogenase if the laboratory performed less than about 35 tests per day. It is unlikely that the use of kits for serum tri-iodothyronine, thyroxine, and thyrotrophic hormone can be justified on economic grounds for any workload. It is estimated that between 2 million pounds and 3 million pounds is spent unnecessarily by the National Health Service each year to purchase commercially prepared reagents for the six tests studied.
 ...
PMID:Comparison of cost of preparing reagents in laboratory with cost of using commercial kits. 7 63

In 73 patients with HBsAg negative hepatitis and in 94 patients with HBsAg positive hepatitis (hepatitis B) laboratory findings were compared: GOT, GPT, AP, gamma-GT, bilirubin, sedimentation rate and gamma-globulins. In the beginning of the disease there was little difference. But comparing the maximal values patients with hepatitis B showed significantly higher GOT, GPT, de-Ritis, and bilirubin levels than patients with HBsAg-negative hepatitis. There was a correlation between de Ritis quotient and bilirubin. The difference of HBsAg negative and HBsAg positive hepatitis might be due to different reactions of cellular mediated immunity.
 ...
PMID:[The different biochemical course of HBsAg-negative and HBsAg-positive hepatitis (author's transl)]. 7 13

Plasma or serum from 4 patients with acute or chronic non-A, non-B post-transfusion hepatitis (P.T.H.) and from a blood-donor implicated in two cases of P.T.H. was inoculated into 5 chimpanzees. Biochemical and histological evidence of hepatitis developed in these 5 chimpanzees but not in a control animal. The mean incubation period in the chimpanzees was 13.4 weeks, compared with 7.7 weeks in the 4 patients with P.T.H. The peak alanine aminotransferase (A.L.T.) levels in the 5 chimpanzees were 265, 212, 219, 70, and 62 I.U./l. Histological changes ranged from mild to conspicuous hepatitis and generally correlated with the degree of A.L.T. elevation. There was no evidence of clinical disease and all animals went on to biochemical and histological recovery. There was no serological evidence of type A or type B hepatitis. Hepatitis was transmitted by serum derived from patients with chronic as well as acute hepatitis, strongly suggesting a chronic carrier state for the agent responsible for non-A, non-B hepatitis. Non-A, non-B hepatitis thus seems to be due to a transmissible agent which can persist and remain infectious for long periods.
 ...
PMID:Transmissible agent in non-A, non-B hepatitis. 7 17

The relationship between plasma protein bound iodine (PBI) level and creatine kinase (CK) activity was investigated in 143 males and 528 females suspected of various thyroid disorders; there was significant negative correlation between low PBI level and raised CK activity. CK, aldolase, lactate dehydrogenase (LD), aspartate transaminase (AST), and alanine transaminase (ALT) activities were determined in plasma from patients with reduced PBI levels; apart from CK, LD was the only enzyme increased in an appreciable number of cases. A further series of specimens was collected from 66 patients with low PBI levels and the CK isoenzymes investigated. In all of these MM was the main form present; a trace of MB was found in 6. These findings do not explain the elevation of CK in hypothyroidism which may be a non-specific effect.
 ...
PMID:An investigation into creatine kinase and other plasma enzymes in thyroid disorders. 7 98

A prospective double-blind controlled study was performed on the effects of isoprinosine in 81 patients with clinical and histological features of classical acute viral hepatitis. Appetite was assessed daily. Serum alanine aminotransferase, aspartic aminotransferase, and bilirubin levels were assessed weekly. Changes in biochemical parameters, number of deaths, number of patients showing rise of aminotransferase levels despite treatment, and duration required for appetite to return to normal in each group were compared. Observation was continued for 4 weeks. Contrary to preliminary reports, no therapeutic benefit was demonstrated in any of these parameters. We concluded that isoprinosine was ineffective in the acute phase of classical acute viral hepatitis.
 ...
PMID:Isoprinosine in classical acute viral hepatitis. 8 1

Studies on subactute toxicity and its recovery of pepleomycin sulfate (NK631) were carried out in both sexes of rats. NK 631 was administered intraperitoneally in dose levels of 0.3, 0.9, 2.7. 8.1 and 24.3 mg/kg/day for 30 days. After finishing administration of NK 631 for 30 days, 5 animals of each group were proceeded to recovery test for 35 days. During the course of the experiment, the body weight gains were suppressed in all dose levels except in 0.3 mg/kg group of male rats. The deaths were found in the animals treated with doses over 24.3 mg/kg during treatment period and in those over 2.7 mg/kg during recovery period. In biochemical and urinary analysis, the increases of serum GPT, BUN, Mg, Ca and urine glucose were moderately recognized in 8.1 mg/kg group. Additionally, in macroscopical and histopathological findings, bone damage was found in the animals treated with doses over 2.7 mg/kg during treatment and recovery periods. From these results, the maximum safety dose of NK 631 in subacute toxicity using rats were estimated to be about 0.3 mg/kg.
 ...
PMID:[Toxicological studies on pepleomycin sulfate (NK 631) II. Subacute toxicity of pepleomycin sulfate in rats (author's transl)]. 8 5


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>