Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Quail were fed monensin to determine liver damage, as measured by changes in activities of serum enzymes and liver microsomal enzymes. Monensin fed at a therapeutic level of 110 ppm for 2 weeks produced an increase in cytochrome P-450 and cytochrome b5 and induction of the activities of benzphetamine N-demethylase, aminopyrine N-demethylase, and aniline hydroxylase, with no changes in the activities of serum sorbitol dehydrogenase (SDH), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). On the other hand, quail fed 110 ppm, 220 ppm, and 330 ppm monensin in feed for 6 weeks showed a significant rise in SDH and AST activities at 330 ppm but not at 110 ppm and 220 ppm. The manifestations of liver toxicity observed at 330 ppm were accompanied by a significant decrease in all the aforementioned hepatic microsomal mixed-function oxidases. In contrast, quail fed monensin at 110 ppm and 220 ppm for 6 weeks produced no change in these parameters except for benzphetamine N-demethylase, aminopyrine N-demethylase, and aniline hydroxylase, which were significantly increased in birds fed 220 ppm of monensin.
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PMID:Toxicity of dietary monensin in quail. 224 82

Monensin fed to beef cows at levels of 50, 200 or 300 mg daily during late gestation and early lactation induced feed savings of 3.2, 10.5 and 13.5%, respectively, when feed intakes were regulated to produce similar changes in cow weights, condition scores and weight to height ratios during the 168-day feeding period. Feed dry matter intakes were different (P < .05) for the orthogonal single degree of freedom comparisons that were made. The monensin treatments and the adjustments in feed intake associated with them had no apparent effect on (1) calf birth weights, (2) adjusted 205-day weaning weights or (3) first-service conception rates for the cows. Monensin increased (P < .05) the proportion of propionate and the ratio of acetate to propionate in rumen samples taken prepartum, but not in samples taken postpartum. Blood samples obtained at the same time that rumen samples were obtained showed no treatment effects on serum creatinine, lactic dehydrogenase, alkaline phosphatase, inorganic phosphorus, calcium, creatine phosphokinase, glutamic-pyruvic transaminase or total protein.
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PMID:Efficacy of monensin for beef cows. 719 80

Monensin and lead were administered separately or concurrently at different toxic doses to broiler chicks. Administration of lead alone did not result in a significant depression of haematological parameters. Administration of higher levels of monensin caused a reduction in haematocrit and an increase in blood serum levels of alanine aminotransferase, aspartate aminotransferase and cholesterol. Concurrent administration of monensin and lead caused a severe depression of haematological profiles which indicated the existence of an interaction between the two substances. It was concluded that concurrent administration of monensin and lead potentiated the toxic effects of each other.
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PMID:Oral administration of monensin and lead to broiler chicks: effects on haematological and biochemical parameters. 781 Mar 94