Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical efficacy of piperacillin against 74 cases with complicated urinary tract infection was examined. Piperacillin was administered at the dose of 4 g (2 g twice daily) through intravenous drip infusion. The overall clinical value was rated in "excellent", in 9 cases, "moderate" in 34 cases and "poor" in 31 cases with a total efficacy of 58.1%. In the analysis of clinical values based on background, its efficacy was statistically significantly lower in the patients at a higher age, those with complication of diabetes mellitus, and those with indwelling catheter. In operated cases compared to non-operated cases, it was suggested to be more effective for improving the disturbances in urinary flow as a result of the removal of the underlying conditions by the operation. As to bacteriological efficacy, 64 out of 95 strains (67.4%) isolated were eradicated following its administration. Microbes which appeared after its dosing belonged to 9 classes of 18 strains, of which 5 strains (27.8%) of Serratia were identified. Side effects were 2.5% (3/119), no serious cases appeared. Changes in laboratory examination results were elevated GOT (2.5%), GPT (1.7%), and ALP (0.8%) values, all being transient hanges.
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PMID:[Clinical studies of efficacy of piperacillin against complicated urinary tract infections]. 396 5

Piperacillin (PIPC) was administered to 4 cases with obstetrical and gynecological infections and the following results were obtained. 1. PIPC was administered by intravenous drip infusion with 4 g per day for 7--14 days. The clinical efficacy was excellent in 2 cases with postoperative parametritis and good in 2 other cases, 1 with infectious ovarian cystoma and 1 with intrauterine infection. In the latter 2 cases surgical treatment was combined. 2. In laboratory findings GOT and GPT were slightly elevated in 2 cases. The relation between the drug and the abnormality was unclear because these rises may be considered due to the anesthesia or the operation itself.
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PMID:[Clinical evaluation of piperacillin in the field of obstetrics and gynecology]. 621 49