Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report one case of subacute thyroiditis associated with acute hepatitis, which is histopathologically diagnosed. A 43-year-old woman visited our hospital with chief complaints of fever, sore throat and anterior neck pain. Thyroid gland was found to be swollen and tender. Laboratory findings gave high ESR and positive test for CRP. High values of T3, T4 and RT3U indicated that the patient had hyperthyroidism. However no autoantibodies against thyroglobulin and microsome were found. High activities of serum AIP, LAP and gamma-GTP were observed. Serum GOT and GPT activities increased moderately. AIP type 2 was dominant in zymograms. Histopathological findings of liver specimen obtained by needle biopsy showed ballooning degeneration of hepatocytes with a slight focal necrosis and hyaline bodies. In addition bile plugs were observed in some biliary tubules. These findings were consistent with those of acute hepatitis. After three months all laboratory data were found to be within normal ranges and no recurrence has been observed. Subacute hepatitis associated with liver dysfunction is considered to be relatively frequent. However very few reports have been published on the case in which histopathological evidence for acute hepatitis was presented.
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PMID:[A case of subacute thyroiditis associated with acute hepatitis]. 328 15

A 75-year-old man was given a diagnosis of invasive thymoma (WHO type B3, stage IVa) in 2004. He received 8 cycles of chemotherapy with doxorubicin, vincristin, cyclophosphamide and cisplatin from November 2004 to May 2005, combined thoracic radiotherapy (total dosage 60 Gy) in April 2006, and 2 cycles of chemotherapy with carboplatin and paclitaxel from July 2008 to August 2008. He was readmitted to our hospital complaining of fever and neck pain in September 2008. Laboratory data on admission revealed elevated serum levels of CRP, GOT, GPT, LDH, CK, and troponin-I with hypo gamma-globulinemia. Although he received immunoglobulin and antibiotic therapy, he suddenly died of cardiac shock on the 9th hospital day. On postmortem examination of the myocardium, the skeletal muscles of the neck and iliopsoas muscle showed inflammatory cell infiltration containing multinucleated giant cells with degeneration and necrosis of the muscle tissues. These findings were consistent with giant cell myocarditis with polymyositis. Autopsy findings suggested that sudden death was caused by giant cell myocarditis, probably associated with invasive thymoma.
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PMID:[An autopsied case of giant cell myocarditis and myositis associated with invasive thymoma]. 2060 87