Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of the work was to establish the frequency and conditions in which structural and functional changes of the liver might occur in case of long-term amiodarone use, depending on thyroid dysfunction. The study included 80 patients with cardiosclerosis with atrial fibrillation (AF). The patients were assigned to: group I (n=60) - received amiodarone at a maintenance dose for one year (on background of basic therapy); control group (CG) - patients (n=20) who received on the background of basic therapy digoxin and bisoprolol. Biochemical tests were conducted: fT3, thyroid-stimulating hormone (TSH), fT4, anti-TPO Ab, transaminases (ALT, AST), alkaline phosphatase (AF), total bilirubin, thymol test (TT), arginase, gama glutamil transpeptidase (GGT). Thyroid dysfunction during administration of amiodarone was detected in 20 (33.3%) patients of group I - amiodarone-induced hypothyroidism (AmIH) in 12 (20.0%) patients, amiodarone-induced thyrotoxicosis (AmIT) in 8 (13.3%) patients. Cholestasis was detected in 83,3% of patients with AmIH and 75,0% with AmIT, which was accompanied by an increase of the AF activity and GGT, which were more pronounced in case of AmIH. More than half of patients with AmIT presented with increased total bilirubin, ALT and AST activity opposed to sixth of AmIG patients. Increased arginase activity, tendency to increase of TT was determined in almost half of patients with AmIG and AmIT. Amiodarone-induced thyroid dysfunction is characterized by the development of drug-induced hepatocellular toxicity, which is manifested by a cholestatic, cytolytic syndrome and accompanied by an energetic changes in hepatocytes.
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PMID:[HEPATOCELLULAR TOXICITY IN THE BACKGROUND OF AMIODARON-INDUCED THYROID DYSFUNCTION IN PATIENTS WITH ATRIAL FIBRILLATION]. 3201 1