Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 51 cases of liver cirrhosis an increased amount of free protoporphyrins in matured erythrocytes was obvious in 22 cases (43%). In 29 cases (57) the amount of EPP rranged at the normal rate. No relationship was found neither to the blood level of bilirubin, iron, protein or of GOT and GPT nor to different histologic findings in liver biopsy slices. The only relation seemed to be as to the amount of fat deposits in hepatocytes. Cases with a high amount of fat had an increased amount of EPP too. Two groups of liver cirrhosis have been separated: one group with EPP amounts above 27/10(11) and another group with EPP amounts below 27/10(11) e., thus ranging within normal rates. Therefore a partial impairment of function is supposed to be and discussed in regard to steroid metabolism.
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PMID:Alteration of haem synthesis in cirrhosis of the liver. 65 43

A water-soluble polysaccharide named as EPP was isolated and purified from evening primrose by hot water extraction, alcohol-precipitation, anion exchange and gel permeation chromatography. EPP had a weight-average molecular weight of about 9.8 kDa and was composed of glucose (Glc), galactose (Gal), mannose (Man), arabinose (Ara) and rhamnose (Rha) in a molar ratio of 2.4:3.1:1.3:1.9:1.0. After 10 days of administration with EPP to H22 tumor-bearing mice, a significant increase in tumor growth inhibitory rate, body weight, relative spleen weight, lymphocytes proliferation, natural killer (NK) cell activity, macrophage phagocytosis, delayed type hypersensitivity (DTH), white blood cell and lymphocyte counts were observed at the dose of 25, 50 and 100 mg/kg. Meanwhile EPP treatment decreased the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkalines phosphatases (ALP), creatinine and urea of tumor-bearing mice to normal levels. Thus, these data proved that EPP might be employed as effective therapeutic agents in the regulation of diverse immune reactions implicated in cancer.
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PMID:Immunopontentiating activities of the purified polysaccharide from evening primrose in H22 tumor-bearing mice. 2306 37