Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.6.1.2 (
alanine aminotransferase
)
26,722
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Breast white adipose tissue inflammation (BWATi) is associated with obesity and higher breast cancer risk among non-Hispanic white women. Obesity is prevalent in Hispanic/Latina patients with breast cancer, and the occurrence of BWATi in this population is not well-characterized. The association between BWATi and body mass index (BMI) was evaluated in Hispanic/Latina patients with breast cancer who underwent mastectomy. BWATi was defined as the presence of crown-like structures of the breast (CLS-B), detected by CD68 IHC in nontumor breast tissue. BWATi severity was quantified as number of
CLS
-B/cm
2
Adipocyte diameter was measured using hematoxylin and eosin-stained breast tissue sections. Preoperative BMI (within 1 week prior to mastectomy) was categorized as normal (18.5-<25.0 kg/m
2
), overweight (25.0-<30.0 kg/m
2
), class I obesity (30.0-<35.0 kg/m
2
), and class II-III obesity (35.0 kg/m
2
or above). Patient charts were abstracted to record clinicopathologic features and liver function tests <90 days before mastectomy. The study included 91 women (mean age 69 years; range 36-96 years). Prevalence of BWATi increased with BMI (24% in normal weight, 34% in overweight, 57% in class I obesity, and 65% in class II-III obesity;
P
trend
<0.01). Severe BWATi (>0.27 CLS-B/cm
2
) was associated with higher BMI (
P
trend
= 0.046) and greater adipocyte diameter (
P
= 0.04). Adjusting for BMI, neoadjuvant chemotherapy, and elevated
alanine aminotransferase
were associated with severe BWATi, and current smoking was associated with mild BWATi (all
P
< 0.05). BWATi was associated with higher BMI in Hispanic/Latina patients with breast cancer, consistent with previously described associations in other populations.
...
PMID:Obesity-associated Breast Inflammation among Hispanic/Latina Breast Cancer Patients. 3040 70
