Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.6.1.2 (
alanine aminotransferase
)
26,722
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Previous reports of leukemia in hedgehogs are limited. We describe clinicopathologic features of leukemia in 9 hedgehogs, including eosinophilic leukemia (
n
= 3) and
acute leukemia
/leukemic phase of lymphoma (
n
= 6). All 3 hedgehogs with eosinophilic leukemia were older than 2 years of age; in contrast, 4 of 6 cases of
acute leukemia
/lymphoma were <2 years old. Hedgehogs presented for non-specific clinical signs of anorexia and lethargy. On hematologic testing, hedgehogs with eosinophilic leukemia had a marked leukocytosis, consisting mostly of eosinophilic precursors with fewer mature eosinophils, whereas there were 43-97% immature cells (blasts) in the blood of hedgehogs with
acute leukemia
/lymphoma. Anemia (
n
= 6) and/or thrombocytopenia (
n
= 6) were concurrent findings. Increased liver enzyme activities (
alanine aminotransferase
, alkaline phosphatase) and hypoalbuminemia were the common findings on biochemical panels. All cases of eosinophilic leukemia and 4 cases of
acute leukemia
/lymphoma died shortly after diagnosis (median 7 days, range 0-41 days), whereas 2 cases of
acute leukemia
/lymphoma lived for 94 or 101 days. Postmortem examination in 5 cases (1 eosinophilic leukemia, 4
acute leukemia
/lymphoma) showed bone marrow infiltrates, confirming eosinophilic leukemia and
acute leukemia
in 1 and 3 cases, and bone marrow necrosis in 1 animal with
acute leukemia
/lymphoma. Immunohistochemical staining of bone marrow sections confirmed a T-cell
acute leukemia
in 1 case. Several hedgehogs had concurrent carcinomas. Hedgehogs suffer from eosinophilic leukemia and
acute leukemia
/lymphoma. However, classification of
acute leukemia
by lineage was not possible due to lack of hedgehog cross-reactive or species-specific reagents.
...
PMID:Clinicopathologic Findings of Spontaneous Leukemia in 9 Pet African Hedgehogs (
Atelerix Albiventris
). 3211 73
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