Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of dietary thiamin, riboflavin and pyridoxine deficiencies on dimethylnitrosamine-induced lethality and hepatotoxicity were investigated in the rat. Development of deficiencies was monitored by growth rate, food intake, ratio of liver weight to body weight and the biochemical parameters (thiamin diphosphate effects for thiamin deficiency, glutathione reductase activity coefficient for riboflavin deficiency and erythrocyte glutamate-oxaloacetate transaminase activity for pyridoxine deficiency). Thiamin deficiency slightly increased the acute toxicity of dimethylnitrosamine as observed by the lowering of the LD50 dose and the greater increase in the serum glutamate-oxaloacetate transaminase and serum glutamate-pyruvate transaminase levels. Riboflavin deficiency, on the other hand, slightly increased the LD50 dose of dimethylnitrosamine and resulted in less dimethylnitrosamine-induced damage to the liver. Pyridoxine deficiency did not affect the lethal dose nor significantly alter the transaminases levels.
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PMID:Alterations in dimethylnitrosamine-induced lethality and acute hepatotoxicity in rats during dietary thiamin, riboflavin and pyridoxine deficiencies. 225 78

A study was conducted to assess the nutritional status of riboflavin and vitamin B6 of the elderly in Central Kentucky. Elderly subjects aged 60 to 95, including 42 men and 77 women, were randomly selected: 41 from six nursing homes and 78 from private residences. Blood and urine samples were collected for analysis. Riboflavin and vitamin B6 status were assessed by using glutathione reductase activation coefficient and glutamic-pyruvic transaminase activation coefficient, respectively. Glutathione reductase activation coefficients ranged from 0.88 to 1.89 with a mean +/- SD of 1.23 +/- 0.22, and were not significantly correlated with the urinary excretion of riboflavin. Glutamic-pyruvic transaminase activation coefficients ranged from 0.86 to 1.50 with a mean +/- SD of 1.16 +/- 0.14, and were negatively correlated with urinary excretion of 4-pyridoxic acid. Riboflavin deficiency was found in 34.2 percent of the institutionalized and 27.7 percent of the non-institutionalized subjects, while vitamin B6 deficiency was found in 56.6 percent of the institutionalized and 43.5 percent of the non-institutionalized subjects studied. The institutionalized elderly showed significantly poorer riboflavin status (P less than 0.01) and vitamin B6 status (P less than 0.05) than the non-institutionalized elderly. Aging was associated with a significant decline in both riboflavin (P less than 0.01) and vitamin B6 status (P less than 0.05).
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PMID:Biochemical evaluation of riboflavin and vitamin B6 status of institutionalized and non-institutionalized elderly in Central Kentucky. 731 23