Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.2 (alanine aminotransferase)
 26,722 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

At the present time liver biopsy is the most reliable method to determine the grade of necroinflammatory lesion and the amount of fibrosis in chronic hepatitis C. Therefore the liver biopsy should always be performed before initiating therapy. It is suggested to use the METAVIR histological activity to grade chronic hepatitis because it is simple, the reproducibility has been validated, the criteria used to define different lesions has been clearly stated, and there is a significant association between ALT levels and this index. The use of semi-quantitative systems in routine reports of liver biopsies is unnecessary. In these cases the schematic diagrams from Batts and Ludwig can be used, as visual analogue scales, in order to grade and stage chronic hepatitis.
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PMID:[Role of liver biopsy in chronic hepatitis C]. 1271 49

The aim of the study was to evaluate the serum TGF-beta 1, IL-12 and IL-5 concentration in children with chronic hepatitis (ChH) B. The study included 62 children with histopathologically diagnosed chh B. The stage of fibrosis and inflammation grade were assessed according to Batts and Ludwig and Ishak et al. The control group consisted of 9 children without clinical signs of infectious and chronic diseases. Serum TGF-beta 1 concentration was significantly elevated in patients with chronic hepatitis B (p = 0.0077) as compared to controls; there were no significant differences in serum concentrations of IL-12 and IL-5 between the examined groups of children. There was also no correlation between serum concentration of the studied cytokines and the degree of fibrosis, inflammation, activity of GPT, GOT, ALP, GGTP and concentrations of bilirubin, proteins or immunoglobulins (G, A, M).
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PMID:[The serum concentration of transforming growth factor beta1, interleukin 12 and interleukin 5 in children with chronic hepatitis B]. 1459 68