Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.6.1.19 (
GABA transaminase
)
808
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In mice, the influence of valproic acid (di-n-propylacetate,
DPA
) on central level of gamma-aminobutyric acid (GABA) as well as the activity of the enzymes regulating GABA metabolism, glutamate decarboxylase (GAD) and
GABA-alpha-oxoglutarate aminotransferase
(
GABA-T
) were studied. It was shown that the elevation of GABA by
DPA
was accompanied by an activation of GAD.
GABA-T
was inhibited only by toxic doses or high concentrations of
DPA
in vivo and in vitro, and so was GAD.
DPA
proved able to antagonize the biochemical alterations induced by convulsant doses of isoniazid, i.e., decreases in the level of GABA and the activity of GAD. These results point to a role of the transmitter pool of GABA regulated by GAD in the anticonvulsant effect of
DPA
.
...
PMID:[On the mechanism of action of valproid acid]. 32 17
The aims of the present studies were (a) to determine the effects of pharmacological elevation of GABA by treatment with
DPA
(competitive inhibitor of
GABA transaminase
) on a form of aggression displayed by grouped female mice towards lactating and non-lactating intruders; (b) to estimate GABA levels in six different brain areas of intact and gonadectomized male and female mice. The results revealed that
DPA
treatment considerably reduced this form of aggression. Increased GABA levels, modulated by the hormonal state of the animals, were observed in most brain areas studied.
...
PMID:Studies on the involvement of GABA in the aggression directed by groups of intact or gonadectomized male and female mice towards lactating intruders. 676 32
The effect of the
GABA transaminase
inhibitor valproic acid (
DPA
) on serotonin (5HT) metabolism of different brain regions were studied in both grouped and isolated rats. One hour after
DPA
injection 5HT levels in the amygdala were increased in grouped and isolated rats. In the hypothalamus of grouped rats, changes in 5HT metabolism were also found. The alteration in 5HT metabolism in grouped rats was reversed 150 min after injection of
DPA
. At this same time, a large and significant increase in 5HT turnover was observed in all brain areas examined in isolated rats. It can be concluded that prolonged isolation induces a differential sensitivity to the effects of
DPA
leading to differences in 5HT metabolism: the drug effect being more intense in isolated rats.
...
PMID:Effect of valproic acid on brain serotonin metabolism in isolated and grouped rats. 681 96
