Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.1 (aspartate aminotransferase)
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Human Gene/Protein
aspartate aminotransferase 14774
alanine aminotransferase 7069
AST 6040
alkaline phosphatase 3556
lactate dehydrogenase 2397
albumin 1860
superoxide dismutase 1735
GSH 1560
Sep 1485
catalase 1353
creatine kinase 1262
glutathione peroxidase 1039
TNF 1031
ALP 874
AAT 845
Mol 791
LDH 782
hemoglobin 778
tumor necrosis factor 744
insulin 739
SOD 598
IL-6 596
GGT 509
caspase-3 497
glutamate pyruvate transaminase 462
lipopolysaccharide 461
HDL 454
cytokine 426
glutamate dehydrogenase 420
prothrombin 400
collagen 398
gamma-glutamyltransferase 385
CAT 340
C-reactive protein 324
glutathione reductase 319
serum albumin 306
myeloperoxidase 299
galactosamine 290
amylase 286
inducible nitric oxide synthase 282
gamma-glutamyl transpeptidase 280
interleukin-6 277
Bcl-2 255
interferon 249
malate dehydrogenase 231
glutathione S-transferase 224
IL-10 220
IFN 216
GTG 214
ATP 210
acid phosphatase 198
LPS 181
Alanine aminotransferase 177
antioxidant enzyme 177
Nrf2 172
ferritin 172
gut 166
SMA 163
TLR4 156
cytochrome P450 155
endoplasmic reticulum 152
microsomal 152
fibrinogen 151
lipase 151
heme oxygenase-1 149
ROS 143
CYP2E1 142
p65 140
GST 139
tumor necrosis factor alpha 134
erythroid 132
serum protein 131
p53 130
TNF-alpha 130
FIB 129
transferrin 125
sorbitol dehydrogenase 123
surface antigen 123
acetylcholinesterase 121
She 118
HO-1 115
smooth muscle actin 113
glutamine synthetase 113
NMR 113
CD4 111
Aspartate aminotransferase 111
CRP 111
GPT 111
myoglobin 109
thromboplastin 108
glucose-6-phosphate dehydrogenase 107
isocitrate dehydrogenase 104
adiponectin 104
lysozyme 103
JNK 102
p38 100
ATPase 98
NAD 97
COX-2 94
cytochrome 93
leptin 93
NADH 92
CPK 92
proliferating cell nuclear antigen 91
PPAR 91
Pol 88
alpha-fetoprotein 85
peroxisome proliferator-activated receptor 85
cyclooxygenase-2 84
gamma-glutamyltranspeptidase 84
MAPK 84
IL-2 82
thymus 81
peroxidase 80
TAT 80
carp 80
IL-8 79
caspase-9 78
cytochrome P450 2E1 78
cytochrome P-450 78
pyruvate kinase 77
reductase 76
Alkaline phosphatase 76
fatty acid synthase 76
IL-4 76
ALB 75
citrate synthase 75
hexokinase 75
HSP70 73
AFP 73
haptoglobin 72
glucose-6-phosphatase 72
AMPK 71
cytochrome c 71
nitric oxide synthase 69
PI3K 68
IL-1 68
glutaminase 68
mTOR 68
xanthine oxidase 67
MCP-1 66
phosphatase 66
CD8 66
phosphoenolpyruvate carboxykinase 66
kit 66
Gen 66
AMP-activated protein kinase 65
A-I 65
alcohol dehydrogenase 65
polypeptide 64
interleukin 6 64
metallothionein 62
glycoprotein 60
ceruloplasmin 60
NADPH 60
NADP 59
Albumin 58
lymphoid 57
ERK 56
IgA 56
more...
Disease
GSH 1560
liver disease 836
cirrhosis 799
cancer 771
hepatitis 749
ischemia 649
fatty liver 640
liver fibrosis 635
diabetes 631
tumor 593
hepatocellular carcinoma 556
chronic hepatitis 535
hepatitis C 465
hepatitis B 452
obesity 386
cholestasis 302
cold 259
anemia 254
sepsis 238
hypertension 235
thrombocytopenia 232
sepsis 226
alcoholic fatty liver 225
myocardial infarction 206
viral hepatitis 202
type 2 diabetes 201
depression 193
chronic liver disease 190
hyperlipidemia 188
metabolic syndrome 178
Nonalcoholic fatty liver 176
HIV 164
acute hepatitis 155
hyperglycemia 154
liver cancer 146
virus infection 135
acute myocardial infarction 128
alcoholism 124
rash 122
cardiovascular disease 118
carcinoma 117
dyslipidemia 113
Hepatotoxicity 113
breast cancer 108
hypercholesterolemia 106
primary biliary cirrhosis 99
infectious diseases 99
atherosclerosis 97
alcohol abuse 97
leukopenia 97
pneumonia 96
neutropenia 94
pruritus 92
liver cancer 92
hypoglycemia 91
hyperbilirubinemia 87
immunodeficiency 87
renal failure 87
hepatitis A 85
tuberculosis 85
myopathy 85
carcinogenesis 84
proteinuria 81
chronic active hepatitis 81
renal disease 81
myocardial ischemia 79
dehydration 78
AAT deficiency 75
viremia 75
malnutrition 72
portal hypertension 71
encephalopathy 71
stroke 69
tumor growth 69
iron overload 69
lymphoma 68
dengue 68
heart failure 66
cholangitis 66
rheumatoid arthritis 66
hepatic encephalopathy 65
emphysema 65
acute pancreatitis 64
AIDS 64
chronic renal failure 59
alcoholic hepatitis 58
cytomegalovirus 57
gallstones 57
acute renal failure 56
coagulopathy 56
West 56
adenocarcinoma 55
pancreatitis 55
malaria 53
metastases 53
B-cell lymphoma 53
lymphopenia 52
plaque 51
Acute liver failure 51
SEM 51
schistosomiasis 50
influenza 50
arthritis 50
eosinophilia 49
sickle cell disease 48
Infection 47
preeclampsia 47
cardiomyopathy 47
Hepatocellular carcinoma 46
thalassemia 45
HCC 45
glucose intolerance 43
asthma 43
lymphadenopathy 43
alcoholic cirrhosis 43
coma 43
chronic obstructive pulmonary disease 42
lung cancer 42
primary sclerosing cholangitis 42
leukemia 42
ASAT 42
hypothyroidism 42
periodontitis 41
fits 41
ACP 41
Cirrhosis 39
disseminated intravascular coagulation 38
epilepsy 38
biliary obstruction 37
abdominal aortic aneurysm 37
prostate cancer 36
SDS 36
Alcoholic liver disease 36
Epstein 36
obstructive jaundice 35
heart disease 34
hyperinsulinemia 34
Evans 34
peritonitis 34
uterus 34
ash 34
FAS 34
worms 34
hyperthyroidism 34
metabolic disorder 33
Alzheimer's disease 33
SARS 33
leishmaniasis 32
ketosis 32
coronary artery disease 32
systemic lupus erythematosus 32
graft-versus-host disease 32
liver metastases 31
AAA 31
Hodgkin's disease 31
melanoma 31
Klebsiella 30
Kawasaki disease 30
acute myeloid leukemia 30
Wilson's disease 30
more...
Symptom
diarrhea 267
fatigue 209
pain 183
anorexia 170
vomiting 167
hepatomegaly 162
nausea 160
anesthesia 148
abdominal pain 139
weakness 101
splenomegaly 82
overweight 81
headache 73
myalgia 73
lethargy 71
cough 69
dyspnea 66
seizures 61
hypothermia 48
starvation 40
nausea and vomiting 40
erythema 39
Ill 36
hepatosplenomegaly 35
chest pain 35
respiratory distress 33
arthralgia 33
chills 33
ataxia 31
collapse 29
exhaustion 28
constipation 25
hypoproteinemia 25
flushing 24
asthenia 23
angina 20
epigastric pain 19
emaciation 19
polyuria 18
decreased appetite 18
oliguria 17
tremor 16
analgesia 15
dizziness 15
polydipsia 15
incoordination 14
discomfort 14
insomnia 14
discomfort 14
sleepiness 13
right upper quadrant pain 12
colic 12
back pain 11
paresis 11
sore throat 11
acute stress 11
shortness of breath 11
functional recovery 11
agitation 10
acidity 10
abdominal discomfort 10
regurgitation 9
hypotonia 9
pallor 9
cachexia 9
cyanosis 9
tachypnea 9
nasal discharge 9
dark urine 8
apathy 8
skin irritation 8
hyperoxia 8
frequent urination 6
fever of unknown origin 6
exertional dyspnea 6
thinning 6
lassitude 5
ketonuria 5
bloating 5
hypercapnia 5
rigors 5
muscle rigidity 5
night sweats 5
bone pain 5
acute abdomen 4
abdominal cramps 4
blurred vision 4
low back pain 4
muscle cramps 4
muscle stiffness 4
consciousness disturbance 4
periorbital edema 4
jaundice of the skin 4
acute pain 4
vertigo 3
hyperemesis gravidarum 3
intestinal bleeding 3
stomach pain 3
dysarthria 3
Decreased activity 3
clubbing 3
stigma 3
dystonia 3
dysuria 3
prostration 3
HSA 3
No adverse effect 3
leg pain 3
nasal congestion 3
despair 3
flank pain 3
Wind 3
rales 3
rhinorrhea 3
memory loss 3
menopausal symptoms 3
hemoptysis 3
bradypnea 3
acute abdominal pain 3
excessive sweating 3
hunger 2
wheezing 2
non-productive cough 2
hyperesthesia 2
hypocapnia 2
Muscle soreness 2
adenitis 2
urinary frequency 2
meningism 2
livedo 2
hypertonia 2
Spots 2
asterixis 2
myoclonus 2
numbness 2
knee pain 2
tonic-clonic seizure 2
twitching 2
dry skin 2
Tenderness 2
Murphy's sign 2
generalized rash 2
spasm 2
hangover 2
cerebellar ataxia 2
hoarseness 2
hot flashes 1
POA 1
Limb weakness 1
Psychiatric symptoms 1
DNA marker 1
tense 1
cancer pain 1
Fluctuation 1
Flu-like symptoms 1
feeling sick 1
drooling 1
orthopnea 1
nocturnal cough 1
hot flushes 1
more...
Drug
vitamin E 240
ascorbate 202
pyridoxal phosphate 171
ROS 143
lysine 126
Ethanol 94
NADH 90
IL-2 83
Asn 66
Monit 65
Cardiovasc 60
Albumin 58
ROC 49
Glutathione 48
IFN-gamma 45
Alanine 44
Vitamin E 43
CTX 41
CSF 40
TAC 40
Portal 38
caffeine 35
Vitamin B 35
ALA 35
Dermatol 33
ACT 33
TAT 30
citric acid 29
Bifidobacterium 28
Serum albumin 28
MAP 27
Leaf 25
niacin 23
AGG 23
lactose 22
CTC 22
Nephron 22
Nephron 22
Dial 21
CTC 21
TTC 20
CTX 19
CTX 19
Heme 19
ZnO 18
Glycyrrhiza 18
CCL 18
Fructose 16
EE2 15
NH3 15
CTT 15
Gel 15
ENT 15
ampicillin 15
Ginseng 14
Tacrolimus 13
Acacia 13
Pyridoxal 13
Isoniazid 13
Rutin 13
Monensin 12
Ringer's solution 12
NAG 11
TiO2 11
Aloe 11
Simvastatin 10
Pyridoxal phosphate 10
L-tyrosine 10
Norplant 9
PCB 9
Prednisolone 9
Biopolymers 9
Rosiglitazone 9
CTA 9
TAK 9
Isotretinoin 9
Emodin 8
Adriamycin 8
Vitamin A 8
Retinoic acid 8
Emodin 8
Fraction 8
Spectrum 7
Swertia 7
Fluorescein 7
Mutagen 7
EPA 7
Infliximab 7
ABC 7
Infliximab 7
ATV 7
DMI 7
AZT 7
OTC 7
Captopril 7
Olive oil 7
MOF 7
Nitric Oxide 6
Doxycycline 6
NAH 6
Asthma 6
Kenyan 6
FAD 6
ETA 6
G-CSF 6
Sorafenib 5
Fluconazole 5
Lovastatin 5
Histamine 5
Entecavir 5
Arsenic trioxide 5
Entecavir 5
Liraglutide 5
Sodium valproate 5
Capsicum 5
CoCl2 5
CoCl2 5
RFP 5
Bosentan 5
DNase I 5
Lead acetate 5
NBT 5
Bosentan 5
Honey 5
Pravastatin 5
Sesame oil 5
HCH 4
TMS 4
Swainsonine 4
Iohexol 4
Furan 4
DPA 4
Artesunate 4
ZnCl2 4
Clofibrate 4
Itraconazole 4
Indocyanine green 4
Ranitidine 4
Caspofungin 4
Senna 4
Trimethoprim-sulfamethoxazole 4
ZnCl2 4
Fipronil 4
Senna 4
MgSO4 4
DM1 4
Tiopronin 4
MRC 4
Propofol 4
CAM 4
Ketoconazole 4
ADR 4
PMEA 4
PTH 4
Sesamol 4
Prednisone 4
Moxifloxacin 4
Gemfibrozil 4
Gastro 4
uPA 4
more...
Enzyme
aspartate aminotransferase 21665
alanine aminotransferase 13093
AST 6039
alkaline phosphatase 3559
lactate dehydrogenase 2637
superoxide dismutase 2253
catalase 1658
creatine kinase 1617
gamma-glutamyl transpeptidase 1479
glutathione peroxidase 1054
glutamate dehydrogenase 443
glutamate dehydrogenase 440
glutamate dehydrogenase 438
peroxidase 379
caspase-3 374
glutathione S-transferase 366
glutathione reductase 320
malate dehydrogenase 294
acetylcholinesterase 277
mitogen-activated protein kinase 268
cholinesterase 205
acid phosphatase 198
lipase 160
glucose-6-phosphate dehydrogenase 140
ERK 131
AMP-activated protein kinase 128
sorbitol dehydrogenase 124
ATPase 120
isocitrate dehydrogenase 120
glutamine synthetase 116
protein kinase 108
isocitrate dehydrogenase 107
thromboplastin 107
lysozyme 104
aldolase 98
phosphoenolpyruvate carboxykinase 98
phosphoenolpyruvate carboxykinase 98
phosphoenolpyruvate carboxykinase 96
alcohol dehydrogenase 80
citrate synthase 79
pyruvate kinase 78
hexokinase 75
AMPK 74
glucose-6-phosphatase 73
focal adhesion kinase 72
AMPK 71
glutaminase 70
xanthine oxidase 68
succinate dehydrogenase 68
collagenase 65
trypsin 63
NQO1 62
ceruloplasmin 61
tyrosine aminotransferase 59
caspase-9 58
transpeptidase 56
arginase 53
luciferase 52
reverse transcriptase 49
acetyl-CoA carboxylase 48
MDH 45
MDH 45
aldehyde dehydrogenase 43
AGT 43
heme oxygenase 42
demethylase 41
phosphoglucose isomerase 41
alpha-amylase 40
neutrophil elastase 39
pyruvate carboxylase 38
6-phosphogluconate dehydrogenase 38
6-phosphogluconate dehydrogenase 38
CYP3A4 36
phosphoenolpyruvate carboxylase 36
cytochrome oxidase 35
CPT 35
leucine aminopeptidase 35
alpha-ketoglutarate dehydrogenase 35
PARP 35
beta-glucuronidase 35
pyruvate dehydrogenase 34
phosphoglucomutase 34
NO synthase 34
thrombin 34
fumarase 32
delta-aminolevulinic acid dehydratase 32
aldehyde dehydrogenase 31
glutamate decarboxylase 31
ACE 31
phosphofructokinase 31
5'-nucleotidase 31
elastase 31
ornithine transcarbamylase 31
TAT 30
lactic acid dehydrogenase 29
gamma-glutamylcysteine synthetase 29
caspase-8 28
complex I 28
caspase-1 28
lipoprotein lipase 28
aldehyde dehydrogenase 28
glutamate synthase 28
aldehyde dehydrogenase 28
aromatic amino acid aminotransferase 28
NOS 28
aldehyde dehydrogenase 28
adenosine deaminase 27
glutamic dehydrogenase 27
ornithine aminotransferase 26
glucokinase 26
phosphorylase 25
glyceraldehyde-3-phosphate dehydrogenase 25
glutamate synthase 25
diaphorase 25
MIP 25
ECH 24
pyruvate dehydrogenase 24
GABA transaminase 24
pyruvate dehydrogenase 24
GSK 24
glutamate synthase 23
ACS 23
UDP-glucuronosyltransferase 23
CPR 23
adenosine deaminase 23
phospholipase A2 22
thymidine kinase 22
transketolase 22
aconitase 22
PGM 22
beta-galactosidase 21
renin 21
protein kinase C 21
NADPH oxidase 21
CGT 20
glyceraldehyde-3-phosphate dehydrogenase 20
monoamine oxidase 20
RNA polymerase 20
carboxylesterase 20
CYP7A1 19
APC 19
hexosaminidase 19
asparagine synthetase 19
NADPH oxidase 19
CPT 19
CPT 19
type III procollagen 19
glyceraldehyde-3-phosphate dehydrogenase 19
paraoxonase 18
enolase 17
fructose 1,6-bisphosphatase 17
RNase 16
ADH 16
MAP 16
transcriptase 16
adenylate kinase 16
branched-chain aminotransferase 16
chymotrypsin 15
DNA polymerase 15
ornithine decarboxylase 15
more...
Compound
glucose 2464
creatinine 2388
urea 2191
GSH 1597
GSH 1597
Clin 1488
Dec 1481
water 1181
nitrogen 1062
TNF 1031
DNA 989
alanine 881
ALP 874
Pac 874
oxygen 852
sodium 844
AAT 841
calcium 797
ethanol 769
phosphate 642
MDA 562
potassium 558
CCl4 553
glutamate 538
nitric oxide 486
iron 396
phosphorus 394
CAT 348
CAT 340
CAT 340
APAP 308
ammonia 294
2-oxoglutarate 275
acetate 257
zinc 242
cysteine 234
copper 228
methionine 220
hydrogen 219
ATP 210
arginine 198
sulfate 198
glutamine 197
lysine 182
selenium 179
cadmium 168
galactose 162
tyrosine 146
Asp 144
His 143
leucine 142
methanol 140
hyaluronic acid 133
N-acetylcysteine 129
Phe 128
salt 122
nitrate 120
NAD 118
GPT 111
CO2 108
serine 107
ammonium 101
GSSG 100
NAD 97
DPPH 94
NADH 90
Lactate 86
MTT 85
tryptophan 84
PEG 83
NH2 82
tryptophan 82
ethyl acetate 81
tryptophan 80
tryptophan 80
NADP 79
alcohol dehydrogenase 79
aspartic acid 79
Silymarin 78
threonine 75
GTP 74
alloxan 73
aflatoxin B1 72
silver 71
aldehyde 70
Glutamate 69
dUTP 66
mercury 65
gallic acid 65
Insulin 65
Curcumin 65
asparagine 65
8-OHdG 63
H2O2 60
ornithine 60
nicotinamide 60
ornithine 60
ornithine 60
ornithine 60
ornithine 60
NADPH 60
NADPH 60
chloroform 59
homocysteine 58
CoA 58
Bilirubin 57
glutamic acid 57
TCA 57
manganese 57
TEM 56
Ile 56
Malondialdehyde 56
aniline 55
oxalacetate 55
ADP 54
Cholesterol 53
Hematoxylin 52
Adriamycin 51
Gly 50
PLP 50
vitamin D 50
Cardiol 50
ADP 49
ADP 49
valine 48
phenol 48
TAA 48
STZ 48
GABA 47
ADR 47
proline 47
GABA 47
Vitamin E 47
chromium 46
glycerol 45
Quercetin 45
INH 45
Hemoglobin 44
DMSO 44
DDP 44
Alanine 43
AMP 43
PEG 43
MCH 42
bromide 42
aspartic acid 42
acetic acid 41
CTX 41
acetaldehyde 40
iodine 40
isoleucine 40
isoleucine 40
pyridine 40
Lead 39
Arsenic 39
SDS 38
hexane 38
Melatonin 38
DEN 38
cobalt 37
more...