Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.1 (aspartate aminotransferase)
 21,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study was carried out on 23 samples of amniotic fluid taken (by amniocentesis) between 35th and 39th week from pregnant women with arterial hypertension (13 cases of hypertension induced by pregnancy, 5 cases of primary hypertension and 5 cases of hypertension accompanying renal diseases). Seven women undergoing the study gave birth to newborns with symptoms of delayed intrauterine growth below 16 centiles (group examined), 16 mothers gave birth to eutrophic babies (control group). The amniotic fluid of the two groups was studied for the following biochemical indexes: alanine and aspartate aminotransferase alkaline total and thermostabile phosphatase, ceruloplasmin, alpha-amylase, general protein, beta-lipoproteins, cholesterol, uric acid, urea and creatinine. No significant changes were found in the parameters determined between the group examined and the control group.
Ginekol Pol 1989 May
PMID:[Biochemical studies of the amniotic fluid in arterial hypertension in relation to intrauterine growth retardation. I. Parameters of the proteins, lipids, enzymes and renal maturity]. 263 82

In the cerebrospinal fluid and serum the activity was determined of phosphocreatine kinase (CPK), lactic dehydrogenase (LDH), aspartate transaminase (AspAT) and alanine transaminase (AlAT) in 107 cases of multiple sclerosis. The results were compared with those in a control group of neurosis and a highly significant (three times) increase was observed in the activity of CPK and LDH in the cerebrospinal fluid as a result of organic damage to the brain tissue. By chromatographic method direct data were obtained indicating that increased CPK activity in the cerebrospinal fluid was connected with the CK-BB isoenzyme, that is with the cerebral fraction of the enzyme.
Neurol Neurochir Pol
PMID:[Studies of alanine and aspartate transaminases, lactate dehydrogenase and phosphocreatine kinase levels in the cerebrospinal fluid and serum in multiple sclerosis]. 322 55

The aim of this study was tracing of changes in the activity of glutathione peroxidase (GSHPx), glutathione transferase (GSH S-Tr), aspartate aminotransferase (AspAT) and alanine aminotransferase (A1AT) in the brain as a result of diet enrichment with antioxidants: selenium (Se), vitamin E and vitamin B15 (pangamic acid). The experiment was carried out on Wistar rats with initial body weight 150 g. Following prolonged enrichment of diet with Se (0.1 ppm of sodium selenite), vitamin E (6 mg/100 g of diet) and vitamin B15 (2.5 mg/100 g of diet) the following results were obtained. The activity of GSHPx in brain microsomes was not changed after one year of vitamin E administration when it was measured against hydrogen hydroxide and against cumene hydrochloride; vitamin E administration increased the activity of GSH S-Tr in the cytoplasmic fraction of brain cells. Diet enrichment with selenium increased after 12 and 18 months the activity of GSHPx measured against both substrates, and GSH S-Tr activity increased considerably. Presence of vitamin B15 in diet reduced GSHPx activity after one-year or longer administration, after 18 months the activity of GSH S-Tr was reduced also. No changes were noted in the activity of AspAT and A1AT.
Acta Physiol Pol
PMID:The effect of long-term enrichment of diet with selenium, vitamin E and B15 on the activity of certain enzymes in rat brain. 345 69

Malate dehydrogenase (EC 1.1.1.37) and aspartate aminotransferase (EC 2.6.1.1) are present in porcine blood platelets in both mitochondria and the cytosol. The latter enzyme is inhibited in a typical way by aminooxycompounds and cycloserine. Blocking of aminotransferase or inhibition of the mitochondrial dicarboxylate carrier by butylmalonate stimulates lactate production by intact platelets and inhibits their aggregation induced by ADP or collagen. These results indicate that the reoxidation of cytosolic NADH via the malate-aspartate shuttle is important for covering the energy demand of platelets necessary for their stimulation.
Acta Biochim Pol 1987
PMID:Importance of the malate-aspartate shuttle for the reoxidation of glycolytically produced NADH and for cell aggregation in porcine blood platelets. 368 99

Twenty Thoroughbred 3 year old horses (10 stallions and 10 mares), trained and raced at the Warsaw Race-Course were studied from March through November. Blood was taken approximately every 8 weeks to determine the activities of aspartate and alanine transaminases, acid and alkaline phosphatases and aldolase. It was observed that the activities of aspartate aminotransferase and alkaline phosphatase reached their maxima in July and alanine transaminase in May. The activities of acid phosphatase and aldolase showed their minima in July. Comparing these data with the literature it was noted that the changes observed are mainly seasonally-dependent; but, training had some influence on the activity of the enzymes involved in energy metabolism.
Acta Physiol Pol
PMID:Seasonal enzyme activity changes in two aminotransferases AspAT and AlAT, acid and alkaline phosphatases and aldolase in the serum of Thoroughbred horses during a racing season. 653 19

Wistar rats were trained on a moving track or/and had stimulation of the crural muscles with electric current of 50 Hz frequency for 14 days. Dramatic changes were observed in the activity of alanine transaminase (AlAT) and aspartate transaminase (AspAT), which was particularly pronounced during 16 days of follow-up after completion of training and stimulation. Persisting high activity of the enzymes in the white muscle fibres exceeding 2-3 times the control values showed a significant effect of electrostimulation on the metabolism of amino acids enabling the muscles to obtain energy for contraction from non-glycolytic source.
Acta Physiol Pol
PMID:The effect of natural training and electrostimulation on changes of alanine transaminase and aspartate transaminase activity in rat skeletal muscles. 666 11

The reported investigations were carried out in 18 men aged 19 to 23 years in whom 400 ml of whole blood was removed. On the day before bloodletting, one hour and 24 hours after it the studied men carried out a 10 minute exercise on a Monark cycle ergometer at a workload raising the heart rate to 170/min. Before the exercise, immediately after it and in the 30th minute of restitution venous blood samples were taken for determinations of the concentrations of total protein, albumins, free fatty acids, glucose, lactate and pyruvate, and the activity of lactic dehydrogenase, alanine aminotransferase and aspartate aminotransferase. During that time the acid-base equilibrium was determined in capillary blood. After bloodletting the concentrations of albumins, total protein and free fatty acids were decreased parallelly to haematocrit value decrease (p less than 0.05) and glucose concentration increased slightly (p less than 0.05). Enzyme activity was decreased slightly (p greater than 0.05). The partial oxygen pressure decreased, that of carbon dioxide increased, and hydrogen ion concentration rose. These changes were more pronounced after 24 hours than 1 hour after bloodletting. After submaximal exercise and in the 30th minute of restitution as well as 1 and 24 hours after bloodletting the changes in the concentrations of the biochemical parameters, enzyme activity and acid-base equilibrium were similar as after bloodletting.
Acta Physiol Pol
PMID:Changes in the concentrations of certain biochemical parameters in the peripheral blood during exercise and restitution after bloodletting. 718 May 21

The activity of aspartate aminotransferase and alanine aminotransferase and the content of soluble proteins were determined in mice irradiated with single dose of 100 R or injected with turpentine and in mice subjected to both these stress factors. The aim of this study was determination of changes in the activity of both these enzymes in the liver, kidney and spleen within 48 hours). It was found that the action of both these stress factors caused significant changes in the activity of AspAT and A1AT in the first phase of the response of the organism to stress and caused statistically significant changes of this activity on the second day of the experiment.
Acta Physiol Pol
PMID:Changes in the activity of aspartate and alanine aminotransferase caused by aseptic inflammatory reaction and ionizing radiation in the liver, kidney and spleen of mice. 724 98

The activities of cytoplasmic and mitochondrial aspartate aminotransferase isoforms in serum in 20 outpatients with Duchenne's progressive muscular dystrophy and seven carriers of the gene of that disease were determined. The control group consisted of 19 patients with other neuromuscular disorders. Twenty, age-matched healthy persons comprised the normal control group. The activity of the cytoplasmic isoform was increased in 85% of Duchenne's dystrophy cases. In these cases the reaction of the cytoplasmic isoenzyme in the presence of pyridoxal 5'-phosphate was abnormal. In the remaining Duchenne's dystrophy cases normal activity of this isoform and normal stimulation to pyridoxal 5'-phosphate was found. The mitochondrial isoform was significantly increased in 30% of Duchenne's dystrophy cases. In all Duchenne's dystrophy patients the reaction of the mitochondrial isoenzyme to supplementation with pyridoxal 5'-phosphate was normal. We conclude that the evaluation of aspartate aminotransferase isoforms in serum in Duchenne's dystrophy can be of clinical importance, especially in evaluating the degree of muscle cell damage.
Mater Med Pol
PMID:Serum cytoplasmic and mitochondrial aspartate aminotransferase in Duchenne's progressive muscular dystrophy. 760 78

The aim of the investigation was to determine the effect of cryodestruction of the healthy prostate on general condition of dogs. The research was performed on 18 dogs divided into two groups: control and experimental. In the dogs from the experimental group after the laparotomy procedure the prostate was frozen in the repeated cycle using the flat cryoapplicator. The observations were carried out for 6 months. General condition of dogs was controlled, blood was examined and urine analysed. The performed determinations included the activity of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, acid phosphatase and prostatic isoenzyme of acid phosphatase. It has been observed that the cryodestruction procedures of the prostatic gland are well tolerated by dogs. During 3 weeks after the surgery the number of leucocytes in blood increased. An increased drop of the blood cells was observed for 2 weeks after the procedure. Characteristic behaviour was observed in case of the prostatic isoenzyme of acid phosphatase. Immediately after the procedure the increased activity of that enzyme was observed and 24h later its decrease which remained for about 2 weeks. Then the isoenzyme activity increased again and that increase lasted for the period of 2 months.
Arch Vet Pol 1994
PMID:Organism reaction to cryodestruction of the prostatic gland in dogs. 859 Sep 8


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