Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.1 (aspartate aminotransferase)
 21,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Breed differences in resistance or tolerance to naturally acquired gastrointestinal nematodes were compared between Aberdeen Angus (AA) and Santa Gertrudis (SG) weaned steer calves grazing in a temperate environment. Within breeds, one half of the calves was untreated: AAU (n = 17) and SGU (n = 18) while the other half was treated with moxidectin monthly: AAT (n = 14) and SGT (n = 14). All calves were grazed on the same contaminated pasture from autumn to winter, when each group was separated to uninfected paddocks for the remaining period of the study. Faecal egg counts, plasma pepsinogen levels (PPL), herbage larval counts and liveweight (LW) were recorded monthly. Egg counts and PPL of AAU and SGU increased from autumn to early winter when calves showed heavy parasitism (mainly Trichostrongylus axei) and severely sick calves needed emergency treatment. On the clean paddocks, parasitological parameters progressively decreased. Late winter egg counts were higher (P < 0.05) in SGU than in AAU. PPL of SGU were higher than AAU ones, but no significant differences were detected. Larval differential counts of SGU showed fewer Cooperia (P < 0.08) and higher T. axei (P < 0.002) proportions than those of AAU. Numbers of severely sick and dead SGU calves (61%) were greater (P < 0.01) than those numbers of AAU calves (17.5%). Cumulative LW gains differences within SG breed were higher (P < 0.0001) than those differences within AA breed (P < 0.003). LW gains of AAU during autumn-winter period were greater (P < 0.002) than those of SGU.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Comparative effects of nematode infection on Bos taurus and Bos indicus crossbred calves grazing on Argentina's Western Pampas. 757 31

The authors followed up six patients after allograft liver transplantation which have been held in the Transplantation and Surgical Clinic. They routinely examined the serum samples of the patients in the post-transplantation period and made a comparison between the serum concentration of alpha-glutathione-S-transferase (alpha-SGT) and conventional liver function enzymes, like aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in association with acute liver allograft rejection. In two cases the authors found that the alpha-glutathione-S-transferase indicated the allograft liver acute rejection-proved by biopsy-2 days earlier than the transminases. In 1 case the alpha-glutathione-S-transferase serum level decrease followed the early post-transplant high level, showed the normalisation of the liver function, but on the 3, day the new elevation was detected, indicating the early acute rejection, the transminases serum levels in all early post-transplant period were elevated. The results of the follow-up-corresponding with the foreign researches-proved that the alpha-glutathione-S-transferase is a reliable marker of the allograft liver acute rejection, in some cases indicates the rejection diagnosis earlier than the conventional liver function enzymes like transaminases.
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PMID:[Follow-up on alpha-glutathione-S-transferase serum level following liver transplantation]. 909 42

This work is an experimental response to an intriguing paper recently published by Catlow and co-workers, which looked at the computational feasibility of fluorine location in three different all-silica zeotypes (Attfield, M. P.; Catlow, C. R. A.; Sokol, A. A. Chem. Mater. 2001, 13, 4708). The materials were chosen as representative of three unique host locations. Our present work examined the synthesis of zeotypes AST, IFR, and MTT using organo-cations with a strong preference for crystallizing these structures. We studied the effect of reaction time and the H(2)O/SiO(2) reactant ratio. The latter is probably the most important function in these zeolite crystallizations that use HF. As reaction conditions became more dilute, AST gave way to SGT and IFR to MTW as host structures, while the MTT synthesis was invariant. Our reactions were studied in terms of product yield vs time, product organo-cation content, fluorine content, and the representative (29)Si and (19)F NMR spectra for certain samples. A single crystal study was carried out for a sample of MTT. Our results showed that, consistent with other recent studies, low H(2)O/SiO(2) reactant ratios lead to more open framework host structures (i.e., IFR vs MTW), and there is typically a higher uptake of organo-cation and fluorine. The structure may well contain a higher population of 4-rings within the silicate substructure. While MTT that contains no 4-rings was chosen as the best possible candidate to achieve an ion-pair for the organo-cation and fluoride anion within the silicate host, both NMR and single crystal work confirm that fluoride is bonded to a 5-coordinate silica center within the lattice.
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PMID:Studies on the role of fluoride ion vs reaction concentration in zeolite synthesis. 1685 Oct 58