Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.1 (aspartate aminotransferase)
 21,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study was the determination and the comparison of activities of AST, ALT, GGT, 5'-NU and CK in the placental tissues of cows with and without retained fetal membranes. Placental samples were obtained from 16 cows immediately after parturition and divided into 2 groups: A-not retained (n = 10, NRF), B-retained (n = 6, RF). The activities of the examined enzymes were determined in supernatants of homogenized tissues using spectrophotometric methods and ready kits. The activity of AST was statistically significantly lower in the maternal part of the placenta in group B than in group A. There were no differences in ALT activity. The activity of GGT was statistically significantly higher in the maternal part of the placenta in group B than in group A. The activity of 5'-NU was statistically significantly higher in the maternal part than in the fetal part of placenta in both groups examined. The activity of CK did not differ, except for statistically significant lower activity in the fetal part of the placenta in group B. The results can suggest that the metabolism of amino acids is altered to some extend in cases of the retained placenta. Changes in GGT my indicate on imbalance in free radicals generation and neutralisation. Energetic status may not be influenced by the retention of the fetal membranes. Further experiments concerning more frequent sample collecting during whole periparturient period are necessary.
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PMID:Enzyme activities in placental tissues from cows with and without retained fetal membranes. 909 Dec 78

We investigated the effects of Moringa oleifera leaf powder (MOLP) as a dietary supplement on growth performance, gastrointestinal (GIT) morphometry and liver function using weanling Sprague Dawley rats to model humans under ad libitum and restricted feeding. An MOLP-based diet was generated by supplementing normal rat feed with the leaf powder at 20%. Four dietary regimens included normal rat feed fed at 20% of body mass (NRF: ad libitum), NRF fed at 14% of body mass (NRFR, restricted), Moringa-supplemented feeds fed at 20% and 14% of body mass (MOF: ad libitum and MOFR: restrictedly) respectively. Thirty-two pups were randomly assigned to the diets and fed for 5 weeks, after which they were fasted, euthanased and GIT viscera masses, lengths and histology were assessed. Blood was collected for metabolite and markers of liver function assays. Tibiae and femora lengths were used to determine linear growth. Rats fed the restricted diets had lower weekly body mass gains (p = 0.0001) than those on ad libitum feeding; however, they showed compensatory growth by 5 weeks. Terminally, the rats fed MOFR had shorter (p < 0.05) femora and tibiae than their counterparts on the other diets. Except on the caeca, diet had no effect on the absolute masses and lengths of GIT viscera. Relative to tibia length, rats on the MOF had significantly heavier stomachs and caeca and longer small and large intestines than their counterparts on NRF, but this was not supported histologically. Level of feeding and supplementation did not affect blood metabolite concentration, liver glycogen and lipid storage nor the plasma activities AST and ALP in the rats. Supplementing diets with MOLP under restricted access to feed (low calorific supply) might compromise linear growth.
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PMID:Dietary effects of Moringa oleifera leaf powder on growth, gastrointestinal morphometry and blood and liver metabolites in Sprague Dawley rats. 2466 93