Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.1 (aspartate aminotransferase)
 21,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hepatic serine dehydratase activity was significantly lower in the obese Zucker rats. In both skeletal muscle and kidney adenylate deaminase showed a lower activity in the obese animals. In the small intestine the activity of glutamate dehydrogenase was increased while that of glutamine synthetase was reduced. No changes were found in the enzymatic activities of white adipose tissue while those found in brown adipose tissue were lower for glutamine synthetase. Starvation resulted in increase in liver serine dehydratase in the lean animals and in aspartate transaminase in both lean and obese. Kidney aspartate transaminase and glutamine synthetase were increased with starvation in the lean rats while kidney adenylate deaminase and small intestine glutamine synthetase and branched-chain amino acid transaminase were increased with starvation in the obese animals. In brown adipose tissue starvation caused an increase in branched-chain amino acid transaminase in the lean rats while it significantly lowered the adenylate deaminase and increased branched-chain amino acid transaminase in the obese rats.
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PMID:Amino acid metabolism enzyme activities in the obese Zucker rat. 810 Nov 20

Hypoglycemic coma caused by insulin injection to rats with alloxan-induced diabetes was accompanied by an increase in the concentrations of urea and uric acid and decrease in the content of free amino acids in blood plasma. Activities of glutamate dehydrogenase, AMP deaminase, glutaminase, ALT, and AST in the liver of experimental animals increased.
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PMID:Parameters of nitrogen metabolism during insulin hypoglycemia in rats with alloxan-induced diabetes. 1914 18

In order to gain insight into the ammonia-detoxification mechanisms in the brain and liver tissues, we have investigated the effects of hyperammonemia in rats, in vivo, on the activity levels of a number of ammonia- and glutamate-metabolizing enzymes in mitochondria and the cytosolic fractions of the cerebral cortex, cerebellum, hippocampus, striatum and liver. In general, the ammonia metabolizing enzymes - glutaminase, glutamine synthetase, glutamate dehydrogenase, AMP deaminase, adenosine deaminase, as well as aspartate aminotransferase and alanine aminotransferase - are differentially upregulated in various brain and liver regions of the hyperammonemic rats, indicating that divergent ammonia-detoxification mechanisms are involved in the various brain regions and liver in acute hyperammonemia.
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PMID:Differential up-regulation of ammonia detoxifying enzymes in cerebral cortex, cerebellum, hippocampus, striatum and liver in hyperammonemia. 2694 89


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