Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.6.1.1 (aspartate aminotransferase)
 21,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study was designed to test the hypothesis that performing repeated bouts of eccentric exercise when muscles were not recovered from previous exercise would exacerbate muscle damage. Twelve nonweight-trained males (21.7 +/- 2.4 yr) performed three sets of 10 eccentric actions of the elbow flexors (ECC) using a dumbbell that was set at 80% of the preexercise maximal isometric force level. This same exercise was repeated 3 and 6 d after the first exercise. Maximal isometric force, relaxed and flexed elbow joint angle, muscle soreness, plasma creatine kinase, and glutamic-oxaloacetic transaminase activities were assessed. Ultrasound images were taken from the upper arm. These measures (except soreness) were assessed immediately before and after each eccentric exercise bout (ECC1, ECC2, and ECC3) and 3 d after ECC3. Soreness was assessed prior to ECC1 and once a day for 9 d thereafter. All criterion measures changed significantly (P < 0.01) after ECC1. ECC2 and ECC3 performed 3 and 6 d after ECC1 did not exacerbate damage and did not appear to slow the recovery rate. Increased echointensity in ultrasound images was demonstrated following ECC1, but no indication of increased damage was found after ECC2 and ECC3. Strenuous exercise performed with "damaged" muscles did not exacerbate damage or affect the repair process.
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PMID:Muscle damage following repeated bouts of high force eccentric exercise. 853 24

The aim of this study was to examine the impact of prolonged intermittent high-intensity shuttle running on soreness and markers of muscle damage. Sixteen males took part in the study, half of whom were assigned to a running group and half to a resting control group. The exercise protocol involved 90 min of intermittent shuttle running and walking (Loughborough Intermittent Shuttle Test: LIST), reflecting the activity pattern found in multiple-sprint sports such as soccer. Immediately after exercise, there was a significant increase (P < 0.05) in serum activities of creatine kinase and aspartate aminotransferase, and values remained above baseline for 48 h (P < 0.05). Median peak activities of creatine kinase and aspartate aminotransferase occurred 24 h post-exercise and were 774 and 43 U x l(-1), respectively. The intensity of general muscle soreness, and in the specific muscles investigated, was greater than baseline for 72 h after the shuttle test (P < 0.05), peaking 24-48 h post-exercise (P < 0.05). Muscle soreness was not correlated with either creatine kinase or aspartate aminotransferase activity. Soreness was most frequently reported in the hamstrings. Neither soreness nor serum enzyme activity changed in the controls over the 4 day observation period. It appears that unaccustomed performance of prolonged intermittent shuttle running produces a significant increase in both soreness and markers of muscle damage.
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PMID:Muscular soreness following prolonged intermittent high-intensity shuttle running. 1041 66