Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.6.1.1 (aspartate aminotransferase)
 21,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

As the most abundant noncoding RNA in cells, tRNA plays an important role in tumorigenesis and development. The report of tRNA on the pathogenesis of lung adenocarcinoma is rare. It is of great clinical significance to explore the relationship between tRNA expression and prognosis of lung adenocarcinoma. The expression level of tRNAs in lung adenocarcinoma tissues and paracarcinoma tissues was detected using a tRNA RT-qPCR array. A total of 104 lung adenocarcinomas were included in the analysis of the correlation between candidate tRNAs expression and prognosis. A tRNA-based prognostic model was constructed and validated using Cox proportional hazards regression. A nomogram was built to help clinicians develop treatment strategies. We screened a series of differentially expressed tRNAs between lung adenocarcinoma tissues and paracarcinoma tissues. Among these tRNAs, tRNAAsn ATT , tRNAIle AAT , tRNALeu TAA , mt-tRNATrp TCA , mt-tRNALeu TAA , tRNAPro AGG , tRNALys CTT -1 and tRNALeu AAG were associated with the clinicopathological characteristics of lung adenocarcinoma. tRNALys CTT -1 , mt-tRNASer GCT and tRNATyr ATA were associated with cancer-specific survival. We constructed a prognostic model for lung adenocarcinoma using specific tRNA expression levels as reference factors. Multivariate analyses showed that tRNA-based prognostic score was a significant and important prognostic factor. The prognostic model based on the tRNAs expression signatures can help predict the prognosis of patients with lung adenocarcinoma.
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PMID:tRNA-based prognostic score in predicting survival outcomes of lung adenocarcinomas. 3083 40

Euphorbiaceae plants are important as suppliers of biodiesel. In the current study, the codon usage patterns and sources of variance in chloroplast genome sequences of six different Euphorbiaceae plant species have been systematically analyzed. Our results revealed that the chloroplast genomes of six Euphorbiaceae plant species were biased towards A/T bases and A/T-ending codons, followed by detection of 17 identical high-frequency codons including GCT, TGT, GAT, GAA, TTT, GGA, CAT, AAA, TTA, AAT, CCT, CAA, AGA, TCT, ACT, TAT and TAA. It was found that mutation pressure was a minor factor affecting the variation of codon usage, however, natural selection played a significant role. Comparative analysis of codon usage frequencies of six Euphorbiaceae plant species with four model organisms reflected that Arabidopsis thaliana, Populus trichocarpa, and Saccharomyces cerevisiae should be considered as suitable exogenous expression receptor systems for chloroplast genes of six Euphorbiaceae plant species. Furthermore, it is optimal to choose Saccharomyces cerevisiae as the exogenous expression receptor. The outcome of the present study might provide important reference information for further understanding the codon usage patterns of chloroplast genomes in other plant species.
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PMID:Comparative analysis of codon usage patterns in chloroplast genomes of six Euphorbiaceae species. 3193 1

Six neurohypophysial GCTs and 31 normal neurohypophysis were studied by immunohistochemical techniques. The latter were grouped into A (< 5 yr old), B (30-49 yr), and C (> 70 yr). GCTs were all labeled by PNA, and some showed reactivity for S-100 protein, AAT, AAC, and cathepsin B. In addition, some were oxytocin- and vasopressinpositive. Unlike extracranial GCTs, neuron-specific enolase, myelin basic protein, and vimentin were not detected. Glial fibrillary acidic protein, keratin, and desmin were also not observed. In contrast, a few cells of the normal neurohypophysis showed immunoreactivity for AAT, AAC, cathepsin B, and PNA, similar to the cells of GCT. These cells tended to increase in number with age: group A showed fewer cathepsin B-positive cells than groups B and C (p < 0.001). These results show that neurohypophysial GCTs have some features that differentiate them from extracranial GCTs, for which a Schwann cell origin has been proposed by many authors. It was concluded that neurohypophysial GCT may originate from the cells that showed similar immunoreactivity, the "granular" pituicytes. Our results also support the hypothesis that neurohypophysial GCTs are an age-related metabolic disorder of lysosomes rather than true neoplasms.Endocr Pathol 4:140-145, 1993.
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PMID:Immunohistochemical study of granular cell tumors and granular pituicytes of the neurohypophysis. 3237 Apr 28


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