Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.5.1.61 (porphobilinogen deaminase)
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Human Gene/Protein
hydroxymethylbilane synthase 15.5
porphobilinogen deaminase 15.5
cytochrome c-1 14.3
regulator of G-protein signaling 3 14.0
PBG 13.7
ALAS-E 13.6
peptidylprolyl isomerase E 13.6
uroporphyrinogen III synthase 13.4
HMBS 13.3
GABA transport protein 13.0
FKLF 12.8
Int8 12.6
Delta-aminolevulinic acid dehydratase 12.4
FBXO38 12.3
coproporphyrinogen oxidase 12.2
MRPL39 12.2
ALAS1 12.1
eukaryotic translation elongation factor 1 alpha 1 12.0
UROD 12.0
ubiquitously expressed transcript 12.0
RPL35 11.9
p38IP 11.9
UPS 11.9
Uroporphyrinogen decarboxylase 11.9
protoporphyrinogen oxidase 11.9
NF-E1 11.8
delta-aminolevulinate synthase 11.7
heme synthetase 11.7
porphobilinogen synthase 11.6
ferrochelatase 11.5
ribosomal protein L13a 11.5
hypoxanthine phosphoribosyltransferase 1 11.5
peptidylprolyl isomerase A 11.4
Noelin 11.4
succinate dehydrogenase complex subunit A 11.4
TCF11 11.4
variegate porphyria 11.4
p45 NF-E2 11.2
mucin 4 11.2
MRS3/4 11.2
HEM1 11.2
KRT4 11.2
delta-aminolevulinic acid dehydratase 11.1
ATP synthase 6 11.1
ALG8 11.0
H2AFZ 11.0
Protoporphyrinogen oxidase 10.7
BPGM 10.7
PCT 10.6
Ferrochelatase 10.5
MT-CO2 10.5
14-3-3 zeta 10.4
AGRN 10.4
UXT 10.4
RPS9 10.4
cystatin M 10.4
ENH 10.3
Int3 10.3
NHP2 10.3
ubiquitin C 10.3
ribosomal protein L4 10.2
glycophorin B 10.2
ribosomal protein L29 10.1
CD3E 10.1
RPS23 10.0
CD8B 9.9
RPL4 9.9
NF-E2 9.9
LIM and SH3 protein 1 9.8
enhancer of zeste 2 9.8
SPTB 9.6
DOK7 9.6
protamine 2 9.6
OTF-1 9.6
RPL13A 9.5
KLF13 9.5
DNA directed 9.5
ribosomal protein S15 9.5
ribosomal protein P0 9.4
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein 9.4
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Disease
acute intermittent porphyria 13.8
hepatic porphyria 11.8
Hereditary coproporphyria 11.7
variegate porphyria 11.6
porphyria 11.5
coproporphyria 11.4
histrionic personality disorder 9.5
AIP 9.4
Acute encephalopathy 9.3
CEP 9.1
Dubin-Johnson syndrome 8.8
porphyria cutanea tarda 8.8
AIP 8.6
Photosensitization 8.5
enzyme deficiency 8.4
Tonsil 8.2
neurofibrosarcoma 8.1
erythropoietic protoporphyria 7.9
Friend leukemia 7.6
sick building syndrome 7.5
RARS 7.4
SIADH 7.0
sideroblastic anemia 7.0
erythroleukemia 6.9
renal clear cell carcinoma 6.9
plexiform neurofibroma 6.9
hypertensive encephalopathy 6.7
tyrosinemia 6.3
photosensitivity 6.2
MCS 6.1
microcytic anemia 6.1
MCS 6.1
siderosis 5.9
dysautonomia 5.7
homocystinuria 5.7
quadriparesis 5.7
tetraplegia 5.7
metabolic disorder 5.7
Testis 5.6
Testis 5.6
mild mental retardation 5.6
hysteria 5.5
conversion reaction 5.5
organic disease 5.5
psychiatric diagnosis 5.5
SRS 5.4
anaplastic astrocytoma 5.4
sinus tachycardia 5.3
peripheral neuropathy 5.2
spotted fever 5.2
neuropathy 5.1
Fox 5.1
uremia 5.1
stuttering 5.0
minimal residual disease 4.9
Proteinuria 4.9
lymphosarcoma 4.9
Pineal 4.9
Barrett's esophagus 4.8
Luminal 4.8
hyperbilirubinemia 4.7
ichthyosis 4.7
Friedreich's ataxia 4.6
chronic renal insufficiency 4.6
schizoaffective disorder 4.5
chlorosis 4.5
ichthyosis 4.5
genetic disorder 4.5
biliary obstruction 4.3
hemolytic anemia 4.3
laryngeal cancer 4.3
polyneuropathy 4.3
trisomy 4.2
laryngeal cancer 4.2
Posterior 4.2
EMT 4.1
ACP 4.1
delirium 4.1
encephalopathy 4.0
anemia 4.0
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Symptom
generalized abdominal pain 9.0
astasia 8.7
Physical findings 7.2
stomach pain 6.6
acute abdominal pain 6.2
abdominal pain 5.6
acute abdomen 5.0
fever of unknown origin 4.6
constipation 4.3
HSA 4.1
colic 4.0
vomiting 3.6
chills 3.6
hepatosplenomegaly 3.5
paresthesia 3.3
paresis 3.1
nausea 3.1
agitation 3.1
starvation 3.0
myalgia 2.9
arthralgia 2.8
weakness 2.7
seizures 2.3
sleepiness 2.0
erythema 1.9
acidity 1.7
ataxia 1.7
anesthesia 0.9
headache 0.8
pain 0.4
Drug
ALA 9.2
Heme 7.9
Pyridoxal 7.6
VCR 6.0
Doxycycline 5.5
AMC 5.4
Vitamin B 5.3
Arsenic trioxide 5.3
Paraffin 4.5
Capsicum 4.5
Alanine 4.2
IFN-beta 4.0
DNase I 3.6
NH3 2.8
Leaf 2.8
THF 2.6
Ethanol 2.4
lysine 1.8
MAP 1.7
ROS 1.4
NADH 1.2
ascorbate 1.1
IFN-gamma 0.8
IL-2 0.8
CSF 0.7
Dermatol -0.8
Enzyme
porphobilinogen deaminase 15.6
porphobilinogenase 13.3
mannonate dehydratase 12.3
uroporphyrinogen decarboxylase 12.2
SirB 12.0
coproporphyrinogen oxidase 11.9
glutamyl-tRNA reductase 11.7
protoporphyrinogen oxidase 11.7
L-serine hydro-lyase 11.6
glutamate formiminotransferase 11.6
cobaltochelatase 11.6
ALA synthase 11.5
ferrochelatase 11.5
delta-aminolevulinic acid dehydratase 11.4
CbiX 11.2
CysG 10.8
coproporphyrinogen III oxidase 10.5
chlorophyllase 10.5
glutamate-1-semialdehyde aminotransferase 10.2
Mg-chelatase 9.9
nicotinamidase 8.8
L-serine dehydratase 8.8
protochlorophyllide oxidoreductase 8.3
enoyl-ACP reductase 8.2
enoyl-ACP reductase 8.2
cystathionine gamma-synthase 8.1
phosphoglyceromutase 8.0
Lod 8.0
pantothenate kinase 7.7
deaminase 7.5
glyceraldehyde-3-phosphate dehydrogenase 7.2
glyceraldehyde-3-phosphate dehydrogenase 7.2
glycolate oxidase 7.1
glyceraldehyde-3-phosphate dehydrogenase 7.1
glyceraldehyde-3-phosphate dehydrogenase 7.0
GLO 6.9
hypoxanthine-guanine phosphoribosyltransferase 6.9
heme oxygenase 6.7
cystathionine beta-synthase 6.7
glyceraldehyde-3-phosphate dehydrogenase 6.6
phosphoribulokinase 6.6
ADP-glucose pyrophosphorylase 6.5
cysteine synthase 6.3
tryptophan synthase 6.2
rhodanese 6.1
CEP 6.1
MCS 6.0
peptidyl-prolyl cis-trans isomerase 6.0
TMT 6.0
ECH 5.6
CEP 5.5
rubisco 5.2
phenylalanine hydroxylase 5.2
tyrosinase 5.0
succinate dehydrogenase 4.9
PRA 4.9
nitrite reductase 4.8
nitrite reductase 4.7
TdT 4.7
nitrite reductase 4.7
phosphoglycerate kinase 4.5
glutathione reductase 4.4
SPC 4.3
peroxiredoxin 4.2
demethylase 4.2
firefly luciferase 4.2
ascorbate peroxidase 4.1
ribonucleotide reductase 4.1
ribonucleotide reductase 4.1
transcriptase 4.0
MMP-3 3.9
ATP synthase 3.8
arginase 3.7
DNase 3.7
glucose-6-phosphate dehydrogenase 3.7
glutamate dehydrogenase 3.5
glutamate dehydrogenase 3.5
glutamate dehydrogenase 3.5
citrate synthase 3.5
malate dehydrogenase 3.4
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Compound
hydroxymethylbilane 13.9
Uroporphyrinogen III 12.6
Tellimagrandin I 12.6
uroporphyrin I 12.1
PBG 11.9
coproporphyrinogen III 11.2
delta-aminolevulinic acid 10.9
BeCl2 10.5
Ehrlich's reagent 10.2
Protochlorophyllide 10.1
1,2,4-benzenetriol 10.0
Chlorophyll b 9.8
Chlorophyll b 9.8
Chlorophyll b 9.8
HIS 9.7
Succinylacetone 9.3
N'-methylnicotinamide 9.2
Phenylhydrazine 9.0
Protoporphyrin IX 8.9
protoporphyrinogen IX 8.8
corrin 8.4
Benzidine 8.4
Porphyrin 8.3
Porphyrin 8.3
N-Acetylglucosamine 8.1
DPM 7.8
Heme 7.8
HBC 7.6
Pyridoxal 7.6
Pantothenate 7.6
Chlorophyll 7.5
Chrysin 7.4
LCR 6.9
AIR 6.9
nonanoic acid 6.8
TBP 6.8
Benzene 6.8
PDT 6.6
TBP 6.6
Danazol 6.5
Arsenite 6.3
Hemin 6.3
Hemin 6.3
Hemin 6.3
Hemin 6.3
Hemin 6.1
Luminal 6.0
ENU 6.0
hydroquinone 5.7
butyric acid 5.7
FAP 5.6
FAP 5.6
Doxycycline 5.5
butyric acid 5.4
cyclohexanone 5.4
cyclohexanone 5.4
cyclohexanone 5.4
cyclohexanone 5.4
Bisphenol A 5.4
Bisphenol A 5.4
cyclohexanone 5.4
Bilirubin 5.4
cyclohexanone 5.3
butyric acid 5.3
Catechol 5.3
cyclohexanone 5.3
cyclohexanone 5.3
DPA 5.3
5-HIAA 5.1
Catechol 5.0
TAA 4.9
cyclohexanone 4.9
Proline 4.8
DTT 4.6
Genistein 4.6
dATP 4.6
DTT 4.6
UGA 4.5
Cobalt 4.5
thioglycollate 4.3
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