Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.5.1.61 (porphobilinogen deaminase)
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Human Gene/Protein
hydroxymethylbilane synthase 15.5
porphobilinogen deaminase 15.5
cytochrome c-1 14.3
regulator of G-protein signaling 3 14.0
PBG 13.7
peptidylprolyl isomerase E 13.6
ALAS-E 13.6
uroporphyrinogen III synthase 13.4
HMBS 13.3
GABA transport protein 13.0
FKLF 12.8
Int8 12.6
Delta-aminolevulinic acid dehydratase 12.4
FBXO38 12.3
coproporphyrinogen oxidase 12.2
MRPL39 12.2
ALAS1 12.1
eukaryotic translation elongation factor 1 alpha 1 12.0
ubiquitously expressed transcript 12.0
UROD 12.0
RPL35 11.9
p38IP 11.9
UPS 11.9
Uroporphyrinogen decarboxylase 11.9
protoporphyrinogen oxidase 11.9
NF-E1 11.8
delta-aminolevulinate synthase 11.7
heme synthetase 11.7
porphobilinogen synthase 11.6
ferrochelatase 11.5
hypoxanthine phosphoribosyltransferase 1 11.5
ribosomal protein L13a 11.5
peptidylprolyl isomerase A 11.4
succinate dehydrogenase complex subunit A 11.4
Noelin 11.4
TCF11 11.4
variegate porphyria 11.4
p45 NF-E2 11.2
mucin 4 11.2
MRS3/4 11.2
more...
Disease
acute intermittent porphyria 13.8
hepatic porphyria 11.8
Hereditary coproporphyria 11.7
variegate porphyria 11.6
porphyria 11.5
coproporphyria 11.4
histrionic personality disorder 9.5
AIP 9.4
Acute encephalopathy 9.3
CEP 9.1
Dubin-Johnson syndrome 8.8
porphyria cutanea tarda 8.8
AIP 8.6
Photosensitization 8.5
enzyme deficiency 8.4
Tonsil 8.2
neurofibrosarcoma 8.1
erythropoietic protoporphyria 7.9
Friend leukemia 7.6
sick building syndrome 7.5
RARS 7.4
SIADH 7.0
sideroblastic anemia 7.0
erythroleukemia 6.9
renal clear cell carcinoma 6.9
plexiform neurofibroma 6.9
hypertensive encephalopathy 6.7
tyrosinemia 6.3
photosensitivity 6.2
MCS 6.1
microcytic anemia 6.1
MCS 6.1
siderosis 5.9
dysautonomia 5.7
homocystinuria 5.7
quadriparesis 5.7
tetraplegia 5.7
metabolic disorder 5.7
Testis 5.6
Testis 5.6
more...
Symptom
generalized abdominal pain 9.0
astasia 8.7
Physical findings 7.2
stomach pain 6.6
acute abdominal pain 6.2
abdominal pain 5.6
acute abdomen 5.0
fever of unknown origin 4.6
constipation 4.3
HSA 4.1
colic 4.0
vomiting 3.6
chills 3.6
hepatosplenomegaly 3.5
paresthesia 3.3
paresis 3.1
nausea 3.1
agitation 3.1
starvation 3.0
myalgia 2.9
arthralgia 2.8
weakness 2.7
seizures 2.3
sleepiness 2.0
erythema 1.9
acidity 1.7
ataxia 1.7
anesthesia 0.9
headache 0.8
pain 0.4
Drug
ALA 9.2
Heme 7.9
Pyridoxal 7.6
VCR 6.0
Doxycycline 5.5
AMC 5.4
Vitamin B 5.3
Arsenic trioxide 5.3
Paraffin 4.5
Capsicum 4.5
Alanine 4.2
IFN-beta 4.0
DNase I 3.6
NH3 2.8
Leaf 2.8
THF 2.6
Ethanol 2.4
lysine 1.8
MAP 1.7
ROS 1.4
NADH 1.2
ascorbate 1.1
IFN-gamma 0.8
IL-2 0.8
CSF 0.7
Dermatol -0.8
Enzyme
porphobilinogen deaminase 15.6
porphobilinogenase 13.3
mannonate dehydratase 12.3
uroporphyrinogen decarboxylase 12.2
SirB 12.0
coproporphyrinogen oxidase 11.9
glutamyl-tRNA reductase 11.7
protoporphyrinogen oxidase 11.7
L-serine hydro-lyase 11.6
glutamate formiminotransferase 11.6
cobaltochelatase 11.6
ALA synthase 11.5
ferrochelatase 11.5
delta-aminolevulinic acid dehydratase 11.4
CbiX 11.2
CysG 10.8
coproporphyrinogen III oxidase 10.5
chlorophyllase 10.5
glutamate-1-semialdehyde aminotransferase 10.2
Mg-chelatase 9.9
nicotinamidase 8.8
L-serine dehydratase 8.8
protochlorophyllide oxidoreductase 8.3
enoyl-ACP reductase 8.2
enoyl-ACP reductase 8.2
cystathionine gamma-synthase 8.1
phosphoglyceromutase 8.0
Lod 8.0
pantothenate kinase 7.7
deaminase 7.5
glyceraldehyde-3-phosphate dehydrogenase 7.2
glyceraldehyde-3-phosphate dehydrogenase 7.2
glycolate oxidase 7.1
glyceraldehyde-3-phosphate dehydrogenase 7.1
glyceraldehyde-3-phosphate dehydrogenase 7.0
GLO 6.9
hypoxanthine-guanine phosphoribosyltransferase 6.9
heme oxygenase 6.7
cystathionine beta-synthase 6.7
glyceraldehyde-3-phosphate dehydrogenase 6.6
more...
Compound
hydroxymethylbilane 13.9
Uroporphyrinogen III 12.6
Tellimagrandin I 12.6
uroporphyrin I 12.1
PBG 11.9
coproporphyrinogen III 11.2
delta-aminolevulinic acid 10.9
BeCl2 10.5
Ehrlich's reagent 10.2
Protochlorophyllide 10.1
1,2,4-benzenetriol 10.0
Chlorophyll b 9.8
Chlorophyll b 9.8
Chlorophyll b 9.8
HIS 9.7
Succinylacetone 9.3
N'-methylnicotinamide 9.2
Phenylhydrazine 9.0
Protoporphyrin IX 8.9
protoporphyrinogen IX 8.8
corrin 8.4
Benzidine 8.4
Porphyrin 8.3
Porphyrin 8.3
N-Acetylglucosamine 8.1
DPM 7.8
Heme 7.8
HBC 7.6
Pyridoxal 7.6
Pantothenate 7.6
Chlorophyll 7.5
Chrysin 7.4
LCR 6.9
AIR 6.9
nonanoic acid 6.8
TBP 6.8
Benzene 6.8
PDT 6.6
TBP 6.6
Danazol 6.5
more...