Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.5.1.61 (
porphobilinogen deaminase
)
637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of human GH and
insulin-like growth factor I
on the proliferation and differentiation of erythroid progenitor cells from the bone marrow and peripheral blood of children were studied in a hormone-depleted culture system. Growth of erythroid progenitors was quantified by directly scoring colonies and by biochemical determination of the activity of a cytosolic enzyme of the heme pathway,
uroporphyrinogen I synthase
. In the presence of erythropoietin, high concentrations (50-100 ng/mL) of human GH induced an increase in the number of erythroid colonies (and their
uroporphyrinogen I synthase
activity) formed by bone marrow or peripheral blood erythroid precursors. In the same conditions, physiological concentrations of
insulin-like growth factor I
(0.5-1 ng/mL) stimulated erythroid cell growth and differentiation (P less than 0.03) from bone marrow or peripheral blood.
...
PMID:Insulin-like growth factor I stimulates human erythroid colony formation in vitro. 358 1
The effect of human somatomedin C/
insulin-like growth factor I
(SM-C/IGF-1) and human growth hormone (hGH) on colony formation by erythroid precursor cells (CFU-E and BFU-E) from children's bone marrow or blood was studied by methylcellulose cloning assay. We found that physiological concentrations of IGF-1, but not of hGH, stimulated erythropoiesis in vitro in the presence of erythropoietin, as demonstrated by the increased activity of a cytosolic enzyme of the heme pathway (
uroporphyrinogen I synthase
). The results suggest that IGF-I could be involved in the regulation of erythroid differentiation.
...
PMID:[Somatomedin C/insulin-like growth factor I and in vitro erythropoiesis]. 362 55
