Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.5.1.61 (
porphobilinogen deaminase
)
637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mutants of Escherichia coli
K12
which accumulated the haem precursor porphobilinogen are described. The mutants grew very slowly on carbon and energy sources which
K12
uses only oxidatively, and they had low catalase activities, suggesting that they were deficient in haem. Extracts had one-tenth of the parental activity of the enzyme
porphobilinogen deaminase
. In transduction, the mutation mapped close to genes ilvD and metE at minute 84. The gene was tentatively identified as hemC, coding for
porphobilinogen deaminase
. The gene symbol hemC replaces the earlier and temporary symbol popE.
...
PMID:Mutants of Escherichia coli K12 accumulating porphobilinogen: a new locus, hemC. 37 77
