Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.5.1.47 (cysteine synthase)
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Human Gene/Protein
G protein beta subunit-like protein 14.6
transposase-like protein 12.8
CYS1 12.7
gamma-glutamyl cyclotransferase 12.5
homeobox A1 11.9
5-oxoprolinase 11.8
CYP20 11.5
cysteine desulfhydrase 11.4
beta-alanine synthase 11.2
CSRP2 11.2
GSH1 11.2
SRXN1 10.9
thiosulfate sulfurtransferase 10.9
Cystathionine gamma-lyase 10.7
glutathione synthetase 10.7
GCS 10.7
DES1 10.6
APS kinase 10.6
gamma-glutamylcyclotransferase 10.6
mercaptopyruvate sulfurtransferase 10.5
TRIM16 10.5
putative oxidoreductase 10.4
microsomal glutathione transferase 10.3
2'-phosphodiesterase 10.3
Glutathione synthetase 10.2
CBS protein 10.2
GSH synthetase 10.2
cystathionine beta-synthase 10.0
GSH2 9.9
GCAT 9.9
aconitate hydratase 9.8
GGT1 9.7
S-adenosylmethionine synthetase 9.7
P67 9.7
LeuRS 9.6
Sgt1 9.6
NADP+-dependent isocitrate dehydrogenase 9.6
ARF7 9.6
glutamate-cysteine ligase modifier subunit 9.5
GCLM 9.5
GSTM2 9.5
glutaredoxin 2 9.5
cystathionine gamma-lyase 9.5
TRX2 9.4
mSR 9.4
phosphoserine aminotransferase 9.4
BUB3 9.4
rotamase 9.4
ADP/ATP translocase 9.3
MMP-19 9.2
GCSh 9.2
glutathione S-transferase pi 9.2
ribosomal protein L3 9.1
NifU 9.1
TXNRD1 9.1
CLPTM1L 9.0
enhancer protein 9.0
2,4-dienoyl-CoA reductase 9.0
cytochrome b561 8.9
Selenoprotein S 8.9
ABCC5 8.9
SAT2 8.8
glutamate-cysteine ligase 8.8
putative membrane protein 8.7
ribosomal protein L7 8.7
A transferase 8.7
PLP 8.6
stiff person syndrome 8.6
DS1 8.6
canalicular multispecific organic anion transporter 8.6
soluble liver antigen 8.5
GSTP1-1 8.4
pyridine nucleotide transhydrogenase 8.4
quinone oxidoreductase 8.4
MTF-1 8.4
aldolase C 8.4
SAT1 8.4
GSTM 8.4
HSPG 8.4
NRF 8.3
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Disease
BSAS 13.6
ovarian serous cystadenocarcinoma 8.5
Tietze 7.8
AD1 7.7
PARK7 7.6
RSI 7.6
memory disorder 7.4
amebiasis 7.4
GSH 7.3
homocystinuria 6.8
cystinosis 6.4
PCS 6.1
RTS 6.0
Brucella abortus 6.0
galactosemia 6.0
RDA 5.8
SCS 5.8
orf 5.8
Familial hypercholesterolemia 5.8
TAM 5.7
Krabbe disease 5.3
PIN 5.3
trichomoniasis 5.3
DES 5.1
Fanconi syndrome 4.9
lymphosarcoma 4.9
EDC 4.9
PAM 4.8
AGA 4.8
kala-azar 4.6
chlorosis 4.5
enterocolitis 4.5
PIN 4.5
ICP 4.3
hypercalciuria 4.3
HSP 4.3
HGF 4.3
leishmaniasis 4.3
coxsackievirus 4.2
African trypanosomiasis 4.1
ACP 4.1
PCC 4.1
AAA 4.1
COPD 4.0
brucellosis 4.0
Rett syndrome 3.9
plasmacytoma 3.9
embryonal carcinoma 3.9
mucosa-associated lymphoid tissue 3.8
insulinoma 3.8
fibrosarcoma 3.8
Mycobacterium 3.8
Haemophilus 3.7
B-cell lymphomas 3.7
urolithiasis 3.7
Fanconi 3.7
Giant 3.7
worms 3.6
ovarian cancer 3.4
chronic myeloid leukemia 3.4
MRS 3.4
primary biliary cirrhosis 3.4
pheochromocytoma 3.4
MIP 3.3
pulmonary edema 3.3
DDP 3.2
male infertility 3.2
gastroenteritis 3.2
epithelial ovarian cancer 3.1
metastatic melanoma 3.0
mammary tumor 2.9
Esophageal 2.9
tuberculosis 2.9
Legionella 2.9
SDS 2.8
memory impairment 2.8
Mycoplasma 2.8
SAR 2.8
glomerulosclerosis 2.8
Melanoma 2.7
more...
Symptom
starvation 4.4
pallor 4.3
hyperoxia 3.3
cachexia 3.2
collapse 0.8
diarrhea 0.8
abdominal pain 0.7
vomiting 0.7
seizures -0.7
pain -2.4
Drug
Trifluoroalanine 14.6
Trifluoromethionine 14.1
O-Acetylserine 13.7
Gly-Tyr-Gly 10.2
Pyridoxal 9.2
pyridoxal phosphate 8.1
Glutathione 7.9
Artesunate 7.2
Vitamin B 6.9
Digitalis 6.4
Glide 6.3
Adenosine triphosphate 5.8
Capsicum 5.5
Vitamin K 5.2
Glycyrrhiza 5.2
Growth hormone 5.1
Growth hormone 5.1
NaI 4.8
NaI 4.8
NaI 4.8
NaI 4.8
ACT 4.6
Paraffin 4.5
Nitric Oxide 4.3
ROS 4.2
Taxol 4.0
MRC 3.9
lysine 3.7
vitamin E 3.5
ABC 3.5
Mutagen 3.1
NH3 2.9
ascorbate 2.7
EE2 2.7
Ethanol 2.4
Gel 1.8
Leaf 1.2
NADH 1.2
IL-2 0.8
Dermatol -2.4
Enzyme
ODAP synthase 15.6
EC 2.5.1.65 15.6
cysteine synthase 15.6
beta-pyrazolealanine synthase 15.6
O-acetyl-L-serine acetate-lyase 14.9
serine acetyltransferase 14.1
quercetin 3-O-methyltransferase 14.1
cystathionine beta-synthase 13.8
beta-cyanoalanine synthase 13.0
cystathionine beta-lyase 12.4
phosphoenolpyruvate-protein phosphotransferase 12.2
homoglutathione synthetase 11.8
5-oxoprolinase 11.8
gamma-glutamylcyclotransferase 11.6
D-cysteine desulfhydrase 11.6
desulfhydrase 11.5
sucrose-phosphatase 11.5
diaminopimelate epimerase 11.5
SsuD 11.4
ketopantoate hydroxymethyltransferase 11.3
2-nitropropane dioxygenase 11.2
ornithine cyclodeaminase 11.2
sulfur reductase 11.0
ATP sulfurylase 11.0
EC 2.3.1.29 10.9
8-amino-7-oxononanoate synthase 10.9
glutathione synthetase 10.9
phytochelatin synthase 10.8
cystathionine gamma-synthase 10.7
DHAD 10.7
sulfite reductase 10.6
methioninase 10.6
homoserine transacetylase 10.5
sulfite reductase 10.4
sulfite reductase 10.4
cystathionine gamma-lyase 10.3
caffeoyl-CoA O-methyltransferase 10.2
CobA 10.2
APS kinase 9.8
leishmanolysin 9.4
D-serine dehydratase 9.4
threonine synthase 9.4
cinnamoyl-CoA reductase 9.4
APS reductase 9.3
isoflavone reductase 9.3
NADPH:quinone oxidoreductase 9.3
tryptophan synthase 9.2
glycerophosphodiester phosphodiesterase 9.2
tyrosine phenol-lyase 9.2
histidinol dehydrogenase 9.1
PTR1 9.0
2,4-dienoyl-CoA reductase 8.9
L-serine dehydratase 8.8
methionine adenosyltransferase 8.8
tryptophanase 8.8
threonine deaminase 8.7
phosphoserine aminotransferase 8.7
alliinase 8.7
alanine racemase 8.3
phosphoglycerate dehydrogenase 8.3
homocysteine methyltransferase 8.3
enoyl-ACP reductase 8.2
enoyl-ACP reductase 8.2
trypanothione reductase 8.2
coproporphyrinogen III oxidase 8.2
gamma-glutamylcysteine synthetase 8.2
TSR 8.1
phosphatidylinositol-4,5-bisphosphate 3-kinase 8.0
transaldolase 8.0
adenylosuccinate synthetase 7.9
dihydrodiol dehydrogenase 7.8
cysteine dioxygenase 7.8
oxalate oxidase 7.8
acetate kinase 7.7
formaldehyde dehydrogenase 7.7
PRPP synthetase 7.7
rhodanese 7.7
pantothenate kinase 7.7
coproporphyrinogen oxidase 7.6
phosphoribulokinase 7.6
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Compound
2-vinylquinoline 14.6
O-acetylserine 13.9
O-acetylserine 13.9
O-acetylserine 13.9
alpha-acetyl-l-lysine 13.3
3-chloroalanine 13.3
3-chloroalanine 13.3
Zwittermicin A 12.5
S-sulfocysteine 11.9
Buthionine sulfoximine 11.8
PDAP 11.7
Victoria Blue BO 11.5
5-oxoproline 10.9
5-oxoproline 10.9
S-methylcysteine 10.8
5-oxoproline 10.7
Methapyrilene 10.3
5-oxoproline 10.3
Echinacoside 10.0
BSO 9.7
SbCl3 9.6
Isoproturon 9.6
Diethyl maleate 9.6
Cysteine 9.4
mercaptopyruvate 9.3
Pyridoxal 9.2
ECS 9.0
Arbutin 8.9
Phosphoserine 8.7
1,2-dichloroethylene 8.5
Cystine 8.5
Cystathionine 8.5
methanethiol 8.5
Cystathionine 8.5
1,2-dichloroethylene 8.4
Hypericin 8.4
PLP 8.4
pyrroline-5-carboxylate 8.4
3GC 8.3
Cystine 8.2
DGE 8.0
DGE 8.0
DGE 8.0
Oridonin 8.0
Farnesol 7.9
meso-diaminopimelate 7.9
Isoflavone 7.8
Digitonin 7.6
Cyanidin 7.5
Chalcone 7.5
cysteine 7.4
Serine 7.4
GSSG 7.3
PYR 7.3
GSH 7.3
GSH 7.3
2-furaldehyde 7.2
H2S 7.2
Ferredoxin 7.2
phosphoserine 7.1
HN2 7.0
D-gluconate 7.0
2-furaldehyde 7.0
H2S 6.9
APS 6.9
homocysteine 6.9
CBS 6.8
Baicalein 6.7
Neutral Red 6.7
Methionine 6.7
Ketoprofen 6.7
Coomassie Blue 6.7
D-Ala-D-Ala 6.7
homoserine 6.6
homoserine 6.6
homoserine 6.6
Carnosine 6.6
DBU 6.6
Emodin 6.6
DAC 6.5
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