Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.5.1.47 (cysteine synthase)
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Human Gene/Protein
G protein beta subunit-like protein 14.6
transposase-like protein 12.8
CYS1 12.7
gamma-glutamyl cyclotransferase 12.5
homeobox A1 11.9
5-oxoprolinase 11.8
CYP20 11.5
cysteine desulfhydrase 11.4
CSRP2 11.2
beta-alanine synthase 11.2
GSH1 11.2
SRXN1 10.9
thiosulfate sulfurtransferase 10.9
Cystathionine gamma-lyase 10.7
glutathione synthetase 10.7
GCS 10.7
DES1 10.6
APS kinase 10.6
gamma-glutamylcyclotransferase 10.6
mercaptopyruvate sulfurtransferase 10.5
TRIM16 10.5
putative oxidoreductase 10.4
microsomal glutathione transferase 10.3
2'-phosphodiesterase 10.3
Glutathione synthetase 10.2
CBS protein 10.2
GSH synthetase 10.2
cystathionine beta-synthase 10.0
GSH2 9.9
GCAT 9.9
aconitate hydratase 9.8
GGT1 9.7
S-adenosylmethionine synthetase 9.7
P67 9.7
LeuRS 9.6
Sgt1 9.6
NADP+-dependent isocitrate dehydrogenase 9.6
ARF7 9.6
glutamate-cysteine ligase modifier subunit 9.5
GCLM 9.5
GSTM2 9.5
glutaredoxin 2 9.5
cystathionine gamma-lyase 9.5
TRX2 9.4
phosphoserine aminotransferase 9.4
mSR 9.4
BUB3 9.4
rotamase 9.4
ADP/ATP translocase 9.3
MMP-19 9.2
GCSh 9.2
glutathione S-transferase pi 9.2
ribosomal protein L3 9.1
TXNRD1 9.1
NifU 9.1
CLPTM1L 9.0
enhancer protein 9.0
2,4-dienoyl-CoA reductase 9.0
cytochrome b561 8.9
Selenoprotein S 8.9
ABCC5 8.9
SAT2 8.8
glutamate-cysteine ligase 8.8
ribosomal protein L7 8.7
A transferase 8.7
putative membrane protein 8.7
PLP 8.6
stiff person syndrome 8.6
DS1 8.6
canalicular multispecific organic anion transporter 8.6
soluble liver antigen 8.5
pyridine nucleotide transhydrogenase 8.4
GSTP1-1 8.4
quinone oxidoreductase 8.4
MTF-1 8.4
aldolase C 8.4
SAT1 8.4
HSPG 8.4
GSTM 8.4
NRF 8.3
coproporphyrinogen oxidase 8.3
GSTM3 8.3
FHC 8.3
multidrug resistance associated protein 8.3
cys 8.3
GSR 8.3
ribosomal protein S12 8.2
Cystinosis 8.2
B-5 8.2
HAC1 8.2
adenylosuccinate synthetase 8.1
ABCC3 8.1
transaldolase 8.1
quinone reductase 8.1
SAT 8.0
sodium-potassium ATPase 8.0
L20 8.0
CYP2E1 protein 8.0
cysteine dioxygenase 8.0
SLC7A11 8.0
thioredoxin reductase 1 8.0
4F) 8.0
MRP5 8.0
NQO1 8.0
SGK 7.9
GCLC 7.9
NADH diaphorase 7.9
dihydrodiol dehydrogenase 7.9
TR1 7.9
sulfate transporter 7.8
eukaryotic translation initiation factor 5A 7.8
lipoamide 7.8
GSS 7.8
TUB 7.8
NF-E2-related factor 2 7.7
AD1 7.7
threonine deaminase 7.7
NIF 7.7
PPIase 7.7
msrA 7.7
EF-Ts 7.7
pantothenate kinase 7.6
GCL 7.6
glutathione peroxidase 1 7.6
alpha-tocopherol transfer protein 7.6
cytochrome P450 2E1 7.6
multidrug resistance-associated protein 7.6
thioredoxin peroxidase 7.6
mitochondrial aconitase 7.5
cytochrome P450 1A2 7.5
CS1 7.5
Se2 7.5
cysteine desulfurase 7.5
nuclear factor I 7.5
SOD3 7.5
methionine aminopeptidase 7.5
CS3 7.4
gamma-glutamyl transpeptidase 7.4
IscS 7.4
HINT 7.4
GRID 7.4
p45 7.4
APR 7.4
acetyltransferase 7.4
SN1 7.4
gamma-glutamylcysteine synthetase 7.4
pyrroline-5-carboxylate synthetase 7.4
CS protein 7.3
IL12B 7.3
GSH 7.3
gamma-glutamyltranspeptidase 7.3
glutathione reductase 7.3
HN2 7.2
P42 7.2
Hsp20 7.2
prolyl endopeptidase 7.2
PARK7 7.2
L-lactate dehydrogenase 7.1
GPX2 7.1
TH protein 7.1
more...
Disease
BSAS 13.6
ovarian serous cystadenocarcinoma 8.5
Tietze 7.8
AD1 7.7
PARK7 7.6
RSI 7.6
memory disorder 7.4
amebiasis 7.4
GSH 7.3
homocystinuria 6.8
cystinosis 6.4
PCS 6.1
RTS 6.0
Brucella abortus 6.0
galactosemia 6.0
RDA 5.8
SCS 5.8
orf 5.8
Familial hypercholesterolemia 5.8
TAM 5.7
Krabbe disease 5.3
PIN 5.3
trichomoniasis 5.3
DES 5.1
Fanconi syndrome 4.9
lymphosarcoma 4.9
EDC 4.9
PAM 4.8
AGA 4.8
kala-azar 4.6
chlorosis 4.5
enterocolitis 4.5
PIN 4.5
ICP 4.3
hypercalciuria 4.3
HSP 4.3
HGF 4.3
leishmaniasis 4.3
coxsackievirus 4.2
African trypanosomiasis 4.1
ACP 4.1
PCC 4.1
AAA 4.1
COPD 4.0
brucellosis 4.0
Rett syndrome 3.9
plasmacytoma 3.9
embryonal carcinoma 3.9
mucosa-associated lymphoid tissue 3.8
insulinoma 3.8
fibrosarcoma 3.8
Mycobacterium 3.8
Haemophilus 3.7
B-cell lymphomas 3.7
urolithiasis 3.7
Fanconi 3.7
Giant 3.7
worms 3.6
ovarian cancer 3.4
chronic myeloid leukemia 3.4
MRS 3.4
primary biliary cirrhosis 3.4
pheochromocytoma 3.4
MIP 3.3
pulmonary edema 3.3
DDP 3.2
male infertility 3.2
gastroenteritis 3.2
epithelial ovarian cancer 3.1
metastatic melanoma 3.0
mammary tumor 2.9
Esophageal 2.9
tuberculosis 2.9
Legionella 2.9
SDS 2.8
memory impairment 2.8
Mycoplasma 2.8
SAR 2.8
glomerulosclerosis 2.8
Melanoma 2.7
candidiasis 2.6
Cryptococcus neoformans 2.6
esophageal cancer 2.6
B-cell lymphoma 2.6
diabetic retinopathy 2.6
Chagas 2.6
periodontal disease 2.6
abdominal aortic aneurysm 2.6
esophageal cancer 2.5
genetic disorder 2.5
neurological disease 2.5
cholestasis 2.4
colon cancer 2.4
chronic obstructive pulmonary disease 2.4
diabetic nephropathy 2.2
SCID 2.2
liver cancer 2.1
periodontitis 2.0
acute renal failure 2.0
Parkinson's disease 2.0
ATM 2.0
bacteremia 1.9
NAME 1.9
fatty liver 1.9
STD 1.8
MCF 1.8
ash 1.8
liver cancer 1.7
glioma 1.7
bladder cancer 1.6
cerebral ischemia 1.6
chronic disease 1.5
cold 1.5
vasculitis 1.3
carcinogenesis 1.2
major depressive disorder 1.2
Klebsiella 1.2
renal cell carcinoma 1.2
ischemia 1.2
cornea 1.1
coronary heart disease 1.1
lung carcinoma 1.1
dehydration 1.1
congestive heart failure 1.1
virus infection 1.1
Alzheimer's disease 0.9
neuroblastoma 0.9
malnutrition 0.8
prostate cancer 0.8
abortion 0.8
Hodgkin's disease 0.8
carcinoma 0.7
renal failure 0.7
dysplasia 0.6
melanoma 0.6
hepatocellular carcinoma 0.5
cognitive impairment 0.5
tumor 0.3
cirrhosis 0.3
malaria 0.2
cancer 0.2
anemia -0.0
colorectal cancer -0.1
influenza -0.2
tumor growth -0.2
diabetes -0.4
lung cancer -0.5
lymphoma -0.5
atherosclerosis -0.6
asthma -0.7
leukemia -0.9
obesity -1.3
stroke -1.5
HIV -1.7
depression -1.8
Symptom
starvation 4.4
pallor 4.3
hyperoxia 3.3
cachexia 3.2
collapse 0.8
diarrhea 0.8
abdominal pain 0.7
vomiting 0.7
seizures -0.7
pain -2.4
Drug
Trifluoroalanine 14.6
Trifluoromethionine 14.1
O-Acetylserine 13.7
Gly-Tyr-Gly 10.2
Pyridoxal 9.2
pyridoxal phosphate 8.1
Glutathione 7.9
Artesunate 7.2
Vitamin B 6.9
Digitalis 6.4
Glide 6.3
Adenosine triphosphate 5.8
Capsicum 5.5
Vitamin K 5.2
Glycyrrhiza 5.2
Growth hormone 5.1
Growth hormone 5.1
NaI 4.8
NaI 4.8
NaI 4.8
NaI 4.8
ACT 4.6
Paraffin 4.5
Nitric Oxide 4.3
ROS 4.2
Taxol 4.0
MRC 3.9
lysine 3.7
vitamin E 3.5
ABC 3.5
Mutagen 3.1
NH3 2.9
ascorbate 2.7
EE2 2.7
Ethanol 2.4
Gel 1.8
Leaf 1.2
NADH 1.2
IL-2 0.8
Dermatol -2.4
Enzyme
ODAP synthase 15.6
EC 2.5.1.65 15.6
cysteine synthase 15.6
beta-pyrazolealanine synthase 15.6
O-acetyl-L-serine acetate-lyase 14.9
serine acetyltransferase 14.1
quercetin 3-O-methyltransferase 14.1
cystathionine beta-synthase 13.8
beta-cyanoalanine synthase 13.0
cystathionine beta-lyase 12.4
phosphoenolpyruvate-protein phosphotransferase 12.2
homoglutathione synthetase 11.8
5-oxoprolinase 11.8
gamma-glutamylcyclotransferase 11.6
D-cysteine desulfhydrase 11.6
desulfhydrase 11.5
sucrose-phosphatase 11.5
diaminopimelate epimerase 11.5
SsuD 11.4
ketopantoate hydroxymethyltransferase 11.3
2-nitropropane dioxygenase 11.2
ornithine cyclodeaminase 11.2
sulfur reductase 11.0
ATP sulfurylase 11.0
EC 2.3.1.29 10.9
8-amino-7-oxononanoate synthase 10.9
glutathione synthetase 10.9
phytochelatin synthase 10.8
cystathionine gamma-synthase 10.7
DHAD 10.7
sulfite reductase 10.6
methioninase 10.6
homoserine transacetylase 10.5
sulfite reductase 10.4
sulfite reductase 10.4
cystathionine gamma-lyase 10.3
CobA 10.2
caffeoyl-CoA O-methyltransferase 10.2
APS kinase 9.8
leishmanolysin 9.4
D-serine dehydratase 9.4
cinnamoyl-CoA reductase 9.4
threonine synthase 9.4
APS reductase 9.3
isoflavone reductase 9.3
NADPH:quinone oxidoreductase 9.3
tryptophan synthase 9.2
glycerophosphodiester phosphodiesterase 9.2
tyrosine phenol-lyase 9.2
histidinol dehydrogenase 9.1
PTR1 9.0
2,4-dienoyl-CoA reductase 8.9
L-serine dehydratase 8.8
methionine adenosyltransferase 8.8
tryptophanase 8.8
threonine deaminase 8.7
alliinase 8.7
phosphoserine aminotransferase 8.7
alanine racemase 8.3
phosphoglycerate dehydrogenase 8.3
homocysteine methyltransferase 8.3
enoyl-ACP reductase 8.2
enoyl-ACP reductase 8.2
trypanothione reductase 8.2
coproporphyrinogen III oxidase 8.2
gamma-glutamylcysteine synthetase 8.2
TSR 8.1
phosphatidylinositol-4,5-bisphosphate 3-kinase 8.0
transaldolase 8.0
adenylosuccinate synthetase 7.9
dihydrodiol dehydrogenase 7.8
cysteine dioxygenase 7.8
oxalate oxidase 7.8
acetate kinase 7.7
formaldehyde dehydrogenase 7.7
PRPP synthetase 7.7
rhodanese 7.7
pantothenate kinase 7.7
coproporphyrinogen oxidase 7.6
phosphoribulokinase 7.6
glutamate synthase 7.6
pyruvate oxidase 7.6
pyruvate oxidase 7.6
tryptophan 2,3-dioxygenase 7.5
glutathione reductase 7.5
dissimilatory sulfite reductase 7.5
serine hydroxymethyltransferase 7.4
LuxS 7.4
leucyl-tRNA synthetase 7.4
MsrA 7.3
orotate phosphoribosyltransferase 7.2
disulfide reductase 7.2
reductoisomerase 7.2
SOR 7.1
fructokinase 7.1
lactate oxidase 7.1
NQO1 7.0
nitrilase 7.0
dUTPase 7.0
methionine synthase 6.9
starch synthase 6.9
acyl-CoA synthetase 6.9
IscS 6.9
acetyl-CoA synthetase 6.8
ascorbate peroxidase 6.8
peroxiredoxin 6.6
gamma-glutamyl transpeptidase 6.6
dehydroascorbate reductase 6.5
ADP-glucose pyrophosphorylase 6.5
CDH 6.5
aconitase 6.4
thioredoxin reductase 6.4
fumarate reductase 6.3
porphobilinogen deaminase 6.3
acyl-CoA synthetase 6.3
cellulose synthase 6.3
rubisco 6.3
glutathione peroxidase 6.3
RNA ligase 6.2
transhydrogenase 6.2
enolase 6.1
glutathione S-transferase 6.1
glutamate synthase 6.1
lactic acid dehydrogenase 6.1
glutamate synthase 6.0
ascorbate oxidase 6.0
peptidyl-prolyl cis-trans isomerase 6.0
prolyl endopeptidase 6.0
ubiquitin-protein ligase 6.0
SPS 6.0
heme oxygenase 5.9
arginine deiminase 5.9
diacylglycerol acyltransferase 5.9
S-adenosylmethionine decarboxylase 5.8
methionine synthase 5.8
malate dehydrogenase 5.8
nitrite reductase 5.8
nitrite reductase 5.8
nitrite reductase 5.7
SCS 5.7
ALA synthase 5.6
ECH 5.6
soluble epoxide hydrolase 5.5
fumarase 5.5
pyruvate dehydrogenase 5.5
pyruvate dehydrogenase 5.5
uricase 5.4
arylsulfatase 5.4
CPS 5.3
glutamine synthetase 5.3
cellulose synthase 5.3
transketolase 5.3
pyruvate dehydrogenase 5.2
diaphorase 5.2
ATP synthase 5.2
acetyl-CoA carboxylase 5.1
6-phosphogluconate dehydrogenase 5.1
6-phosphogluconate dehydrogenase 5.1
DAT 5.1
pyruvate carboxylase 5.1
more...
Compound
2-vinylquinoline 14.6
O-acetylserine 13.9
O-acetylserine 13.9
O-acetylserine 13.9
3-chloroalanine 13.3
alpha-acetyl-l-lysine 13.3
3-chloroalanine 13.3
Zwittermicin A 12.5
S-sulfocysteine 11.9
Buthionine sulfoximine 11.8
PDAP 11.7
Victoria Blue BO 11.5
5-oxoproline 10.9
5-oxoproline 10.9
S-methylcysteine 10.8
5-oxoproline 10.7
Methapyrilene 10.3
5-oxoproline 10.3
Echinacoside 10.0
BSO 9.7
SbCl3 9.6
Diethyl maleate 9.6
Isoproturon 9.6
Cysteine 9.4
mercaptopyruvate 9.3
Pyridoxal 9.2
ECS 9.0
Arbutin 8.9
Phosphoserine 8.7
Cystine 8.5
1,2-dichloroethylene 8.5
Cystathionine 8.5
methanethiol 8.5
Cystathionine 8.5
1,2-dichloroethylene 8.4
Hypericin 8.4
PLP 8.4
pyrroline-5-carboxylate 8.4
3GC 8.3
Cystine 8.2
DGE 8.0
DGE 8.0
DGE 8.0
Oridonin 8.0
Farnesol 7.9
meso-diaminopimelate 7.9
Isoflavone 7.8
Digitonin 7.6
Cyanidin 7.5
Chalcone 7.5
cysteine 7.4
Serine 7.4
GSSG 7.3
PYR 7.3
GSH 7.3
GSH 7.3
2-furaldehyde 7.2
H2S 7.2
Ferredoxin 7.2
phosphoserine 7.1
HN2 7.0
D-gluconate 7.0
2-furaldehyde 7.0
H2S 6.9
APS 6.9
homocysteine 6.9
CBS 6.8
Baicalein 6.7
Neutral Red 6.7
Methionine 6.7
Coomassie Blue 6.7
Ketoprofen 6.7
D-Ala-D-Ala 6.7
homoserine 6.6
homoserine 6.6
homoserine 6.6
Carnosine 6.6
DBU 6.6
Emodin 6.6
DAC 6.5
carbamyl phosphate 6.5
alpha-Tocopherol 6.4
Ursodeoxycholic acid 6.4
CDH 6.3
Vinca 6.2
Sulforaphane 6.1
Menadione 6.0
ISDN 6.0
acetyl-CoA 6.0
norleucine 5.9
serine 5.8
adenosylmethionine 5.8
bis(2-chloroethyl) 5.7
Arsenic 5.7
Thioredoxin 5.7
Cytochrome c 5.7
cyanide 5.7
PABA 5.7
bis(2-chloroethyl) 5.7
Hypo 5.6
NPA 5.6
8-OHdG 5.6
norleucine 5.6
SN-38 5.5
DAP 5.5
DAP 5.5
Carnitine 5.5
Coenzyme Q10 5.4
1H-pyrazole 5.4
methionine 5.3
Homocysteine 5.3
Homocysteine 5.3
Malondialdehyde 5.3
Acetone 5.2
Cap 5.2
tellurium 5.1
DES 5.1
Histidine 5.1
SO3 5.1
DAT 5.1
bis(2-chloroethyl) 5.1
PIN 5.0
N-acetylcysteine 5.0
SOA 4.9
sulfuric acid 4.9
2-nonenal 4.9
Cbl 4.8
EDC 4.8
Pyruvate 4.8
L-carnitine 4.7
Piper 4.7
PPi 4.7
H2O2 4.6
2-mercaptoethanol 4.6
TOF 4.6
cadmium 4.6
PHB 4.6
diacetate 4.6
FFA 4.6
Rifampicin 4.6
4-nitrophenyl 4.5
HgCl2 4.5
ethylbenzene 4.5
ATA 4.5
ASC 4.4
coenzyme Q10 4.4
Ethylene 4.4
MDR 4.4
IAA 4.4
chalcone 4.3
PAM 4.3
sulfate 4.3
Amphotericin B 4.3
CoA 4.3
Hematoxylin 4.3
Ubiquitin 4.3
glutamine 4.3
UDP-glucose 4.2
APAP 4.2
NADPH 4.2
more...