Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.5.1.18 (glutathione S-transferase)
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Human Gene/Protein
glutathione S-transferase 13304
GST 9466
GSH 2583
catalase 2103
glutathione peroxidase 1912
superoxide dismutase 1723
Mol 1722
glutathione transferase 1648
Sep 1597
glutathione reductase 1274
fused 889
SOD 872
cytochrome P450 754
microsomal 692
GSTM1 631
xenobiotic 629
CAT 614
GSTT1 527
SDS 427
GSTP1 422
cytochrome P-450 400
acetylcholinesterase 388
polypeptide 378
peroxidase 370
ATP 368
p53 365
antioxidant enzyme 351
P450 314
cytochrome 298
CYP1A1 278
insulin 266
lactate dehydrogenase 254
NADPH 252
thrombin 241
epoxide hydrolase 240
ubiquitin 236
reductase 234
aspartate aminotransferase 233
ATPase 229
GTP 224
Glutathione S-transferase 223
endoplasmic reticulum 217
Nrf2 215
ROS 215
caspase-3 214
DT-diaphorase 213
alkaline phosphatase 205
alanine aminotransferase 204
interacting protein 198
threonine 193
dimeric 190
phosphatase 188
metallothionein 181
cytokine 181
quinone reductase 178
albumin 174
NAD 174
NQO1 166
P-glycoprotein 164
tyrosine kinase 162
Bcl-2 158
esterase 158
CYP2E1 157
NMR 157
thioredoxin 156
heme oxygenase-1 155
gamma-glutamyl transpeptidase 154
erythroid 153
TNF 149
GTPase 148
glucose-6-phosphate dehydrogenase 148
calmodulin 145
UDP-glucuronosyltransferase 144
proliferating cell nuclear antigen 143
glycoprotein 142
tumor necrosis factor 137
AST 136
p38 135
c-Jun 133
p21 131
Catalase 130
microsomal epoxide hydrolase 129
carboxylesterase 128
HSP70 128
Gen 128
membrane protein 125
AChE 124
proteasome 123
CYP1A2 116
Rho 115
JNK 115
1A1 115
histone 114
proline-rich 112
collagen 112
TOF 111
MAPK 111
CYP 111
estrogen receptor 110
carp 110
LPO 110
heat shock protein 107
IL-6 105
membrane-bound 105
gut 104
AP-1 100
Glutathione transferase 100
GSTP1-1 100
NADH 100
DNA-binding domain 95
ERK 95
GDP 94
LDH 93
epidermal growth factor 92
sulfotransferase 92
quinone oxidoreductase 92
CYP3A 92
GSTA1 92
zinc finger 89
aryl hydrocarbon receptor 88
oxidoreductase 87
protein phosphatase 87
hemoglobin 87
aldehyde dehydrogenase 86
UDP-glucuronyltransferase 83
ras 82
cytochrome b5 82
adaptor protein 81
interferon 81
ERK1 81
nuclear receptor 81
aryl hydrocarbon hydroxylase 81
phosphatidylinositol 3-kinase 80
ADP 80
myeloperoxidase 79
glutaredoxin 79
gamma-glutamylcysteine synthetase 79
Pseudomonas 78
p65 77
ligandin 77
MnSOD 76
Superoxide dismutase 76
gamma-glutamyltranspeptidase 75
MDR1 75
P1b 73
methyltransferase 73
lipopolysaccharide 73
phosphoprotein 71
cyclin 71
acid phosphatase 70
inducible nitric oxide synthase 70
Glutathione peroxidase 70
ALP 70
N-acetyltransferase 69
p85 69
CYP2D6 68
MBP 68
glutathione S-transferase pi 68
PKC 68
HEK 68
more...
Disease
GSH 2585
cancer 2291
tumor 1277
carcinogenesis 1040
SDS 427
hepatocellular carcinoma 381
breast cancer 354
carcinoma 292
tumorigenesis 220
lung cancer 215
leukemia 162
diabetes 158
prostate cancer 148
adenocarcinoma 141
Schistosoma japonicum 138
MCF 128
worms 119
HIV 116
colorectal cancer 112
Alzheimer's disease 112
Schistosoma mansoni 109
melanoma 101
malaria 97
cold 95
liver cancer 92
gastric cancer 88
colon cancer 88
squamous cell carcinoma 86
ischemia 85
herpes simplex 83
hepatitis B 83
tumor growth 81
virus infection 77
immunodeficiency 75
schistosomiasis 73
liver cancer 73
bladder cancer 71
Epstein 69
chemical carcinogenesis 69
Parkinson's disease 69
hepatitis C 67
retinoblastoma 67
depression 65
glioma 65
asthma 64
obesity 62
ovarian cancer 62
tumor progression 61
cirrhosis 61
hypertension 58
lymphoma 56
hepatitis 55
neuroblastoma 53
atherosclerosis 52
adenoma 50
influenza 49
liver disease 48
cytomegalovirus 48
acute lymphoblastic leukemia 46
tuberculosis 45
AIN 43
infectious diseases 43
acute myeloid leukemia 43
non-small cell lung cancer 41
chronic hepatitis 41
metastases 40
dengue 40
DDP 40
renal cell carcinoma 39
epithelial ovarian cancer 38
cardiovascular disease 38
cervical cancer 38
AIDS 36
epididymis 36
HSP 36
Mycobacterium 35
vaccinia 34
hyperglycemia 33
uterus 33
lung carcinoma 33
Echinococcus 32
liver fibrosis 31
Farber 31
multiple myeloma 31
rheumatoid arthritis 30
B-cell lymphoma 29
renal disease 27
stroke 26
chronic obstructive pulmonary disease 26
osteosarcoma 26
Evans 26
dysplasia 25
Yersinia 25
West 25
type 2 diabetes 25
oral cancer 25
pertussis 25
SARS 25
pheochromocytoma 25
Infection 24
fatty liver 24
ATM 24
mammary tumor 24
neoplastic transformation 24
arthritis 24
Kaposi's sarcoma 24
malnutrition 23
small cell lung cancer 23
skin cancer 23
aggressiveness 23
chronic myeloid leukemia 23
anemia 23
male infertility 22
glioblastoma 22
plaque 22
Proteus 22
SEM 22
volvulus 22
DBA 22
infertility 21
cognitive impairment 21
cholera 21
myocardial infarction 21
PAL 21
polycystic kidney 20
plague 20
head and neck cancer 20
dehydration 20
ARF 20
parasitic disease 20
amyotrophic lateral sclerosis 20
cornea 19
basal cell carcinoma 19
Huntington's disease 19
systemic lupus erythematosus 19
acute promyelocytic leukemia 19
schizophrenia 19
NS3 19
solid tumor 19
CHS 19
esophageal cancer 19
immunotoxicity 18
cerebral ischemia 18
TEM 18
erythroleukemia 18
APC 18
Chlamydia 18
myeloid leukemia 18
infestation 18
Mycoplasma 18
cholestasis 17
ash 17
ACP 17
esophageal cancer 17
pancreatic cancer 17
multiple sclerosis 17
pneumonia 17
coronary artery disease 16
Brown 16
inflammatory bowel disease 16
more...
Symptom
starvation 62
diarrhea 37
anesthesia 35
pain 26
seizures 25
collapse 15
hyperoxia 12
fatigue 9
hepatomegaly 9
exhaustion 8
vomiting 5
nausea 5
headache 5
polyuria 4
angina 4
hypothermia 4
acute stress 4
respiratory distress 4
anorexia 4
emaciation 3
memory loss 3
ataxia 3
tremor 3
erythema 2
wheezing 2
tense 2
analgesia 2
dizziness 2
stigma 2
Hudson 2
insomnia 2
arthralgia 2
discomfort 2
cachexia 2
hypotonia 2
hypercapnia 2
polydipsia 2
Spots 2
splenomegaly 2
Welt 2
cough 2
abdominal cramps 2
discomfort 2
thinning 2
acidity 2
dry eye 1
DNA marker 1
dystonia 1
hunger 1
masculinization 1
overweight 1
rundown 1
upset stomach 1
weakness 1
skin irritation 1
wrist pain 1
despair 1
Scratch 1
physical appearance 1
flushing 1
microbial colonization 1
loin pain 1
functional recovery 1
persistent cough 1
acute abdomen 1
bitter taste 1
Neuropathic pain 1
syncope 1
tingling 1
hypoproteinemia 1
chest pain 1
abdominal pain 1
nausea and vomiting 1
partial seizure 1
apathy 1
constipation 1
Fluctuation 1
Wind 1
Anoxia 1
knee pain 1
exertional dyspnea 1
menopausal symptoms 1
HSA 1
chills 1
autodigestion 1
acute abdominal pain 1
Halo 1
incoordination 1
Drug
Glutathione 582
ascorbate 221
ROS 215
lysine 170
vitamin E 158
Gel 89
NADH 83
caffeine 48
Mutagen 45
Adriamycin 45
Asn 44
PCB 43
Vitamin E 42
DNase I 40
ABC 39
IL-2 36
IFN-gamma 36
Dermatol 34
Ethanol 30
Monit 27
ALA 25
Leaf 25
MAP 24
CTX 23
Alanine 23
nitroglycerin 22
ZnO 18
lactose 18
ETS 17
FAD 15
CSF 14
EE2 13
Cardiovasc 13
HCH 13
Albumin 13
Taxol 12
Nephron 12
TAC 11
ADR 11
Arsenic trioxide 11
RFP 11
EPA 11
Cibacron Blue 10
Triclosan 9
CTX 9
G418 9
Indomethacin 9
CTX 9
TAT 9
TiO2 9
Capsicum 9
Oxaliplatin 8
NAG 8
p75 8
Retinoic acid 8
CoCl2 8
CoCl2 8
THF 7
Tannic acid 7
Nitric Oxide 7
VCR 7
ADM 7
VCR 7
citric acid 7
ICI 7
Clofibrate 7
Aloe 7
Bifidobacterium 7
ampicillin 6
Cimetidine 6
Vitamin K 6
Rutin 6
Portal 6
AMC 6
Nephron 6
Paraffin 6
Auranofin 6
Asthma 6
ROC 6
Vitamin A 6
PCP 6
CPT-11 5
Spectrum 5
uPA 5
Kenyan 5
Glycyrrhiza 5
Furan 5
Ginger 5
Carotenoid 5
R1881 5
Estrogens 5
Propofol 5
pyridoxal phosphate 5
CDP 5
Angiotensin II 5
Itraconazole 5
Ginseng 5
MRC 5
Spectrum 4
Abamectin 4
Fluorescein 4
Forskolin 4
Fipronil 4
OTC 4
ETA 4
Isoniazid 4
Myricetin 4
Parkin 4
Areca 4
ZnCl2 4
Cimetidine 4
Parkin 4
ZnCl2 4
Fructose 4
Atrovent 4
Rituximab 4
Heme 4
Fraction 4
Biopolymers 4
IFN-beta 4
PTH 4
IL-1ra 4
NBT 3
CPR 3
DHT 3
Honey 3
AHF 3
Simvastatin 3
Fluorescein 3
GRF 3
Tocopherol 3
balanced salt solution 3
Ketoconazole 3
Indocyanine green 3
L-tyrosine 3
ACT 3
CTA 3
BCG vaccine 3
Lead acetate 3
BH4 3
Omeprazole 3
DHT 3
Bezafibrate 3
CaCl2 3
S-Hexylglutathione 3
Sorafenib 3
NH3 3
Nipradilol 3
CaCl2 3
CaCl2 3
Histamine 2
TEL 2
Atenolol 2
Growth hormone 2
Acacia 2
AGG 2
Limonene 2
PPA 2
Iron dextran 2
Fenbendazole 2
more...
Enzyme
glutathione S-transferase 22582
catalase 2547
superoxide dismutase 2333
glutathione peroxidase 1962
glutathione reductase 1266
NQO1 507
mitogen-activated protein kinase 474
peroxidase 468
acetylcholinesterase 443
protein kinase 437
alanine aminotransferase 414
aspartate aminotransferase 366
gamma-glutamyl transpeptidase 339
UDP-glucuronosyltransferase 297
ATPase 268
lactate dehydrogenase 260
soluble epoxide hydrolase 248
thrombin 230
luciferase 229
glucose-6-phosphate dehydrogenase 211
ERK 208
alkaline phosphatase 205
demethylase 205
protein kinase C 197
P-glycoprotein 167
caspase-3 156
microsomal epoxide hydrolase 151
AST 135
ascorbate peroxidase 133
calcineurin 131
CPR 131
trypsin 130
carboxylesterase 130
proteasome 130
focal adhesion kinase 127
RNA polymerase 114
cholinesterase 111
gamma-glutamylcysteine synthetase 105
aryl hydrocarbon hydroxylase 97
aldehyde dehydrogenase 92
MEK 91
aldehyde dehydrogenase 91
aldehyde dehydrogenase 90
aldehyde dehydrogenase 86
aldehyde dehydrogenase 86
peroxiredoxin 84
topoisomerase 81
phosphatidylinositol 3-kinase 81
reverse transcriptase 78
cdc2 74
N-acetyltransferase 72
topoisomerase 70
acid phosphatase 70
heme oxygenase 69
diaphorase 66
thioredoxin reductase 61
glyceraldehyde-3-phosphate dehydrogenase 61
alcohol dehydrogenase 61
dehydroascorbate reductase 58
lysozyme 58
glyceraldehyde-3-phosphate dehydrogenase 55
xanthine oxidase 55
AMPK 55
CYP3A4 54
phospholipase C 54
PARP 53
RNase 52
PAH 51
lipoxygenase 51
beta-galactosidase 47
creatine kinase 47
ornithine decarboxylase 46
chloramphenicol acetyltransferase 46
glyceraldehyde-3-phosphate dehydrogenase 44
glyceraldehyde-3-phosphate dehydrogenase 44
glyceraldehyde-3-phosphate dehydrogenase 44
DNA polymerase 44
RNase 43
IKK 42
AMP-activated protein kinase 40
pyruvate kinase 39
transcriptase 39
MDR 38
ATP synthase 37
collagenase 37
thymidylate synthase 37
protein phosphatase 2A 36
complex I 35
enolase 35
PAL 35
lipase 34
beta-glucuronidase 34
chymotrypsin 32
NADPH oxidase 32
papain 32
NADPH oxidase 32
monoamine oxidase 31
ACE 31
aldose reductase 30
glutathione synthetase 30
cysteine synthase 30
malate dehydrogenase 29
aldolase 29
sorbitol dehydrogenase 29
caspase-9 29
SOR 28
glutamine synthetase 27
NO synthase 27
MAP 26
succinate dehydrogenase 26
phospholipase A2 26
caspase-8 26
phosphoinositide 3-kinase 25
glyoxalase II 25
thromboplastin 24
ACS 24
enterokinase 24
kinesin 24
carbonic anhydrase 24
chalcone synthase 24
DNA methyltransferase 24
APC 23
PST 23
NOS 23
glutamate dehydrogenase 22
glutamate dehydrogenase 22
glutamate dehydrogenase 22
tyrosinase 22
cathepsin L 21
transpeptidase 21
GSK 21
NADH-cytochrome b5 reductase 21
phosphodiesterase 21
phospholipase D 21
endonuclease 21
paraoxonase 21
pyruvate dehydrogenase 21
dihydrofolate reductase 21
LTC4 synthase 21
PAL 21
delta-aminolevulinic acid dehydratase 21
paraoxonase 20
histone acetyltransferase 20
cathepsin B 20
MEKK1 19
AMPK 19
6-phosphogluconate dehydrogenase 19
6-phosphogluconate dehydrogenase 19
sulfatase 19
transglutaminase 19
ceruloplasmin 19
citrate synthase 19
ECH 19
phosphorylase 19
PDK1 18
glucose-6-phosphatase 18
cathepsin D 18
methylenetetrahydrofolate reductase 18
methylenetetrahydrofolate reductase 18
neuraminidase 18
more...
Compound
GSH 3003
GSH 3003
DNA 2938
Dec 1649
oxygen 1131
water 1052
1-chloro-2,4-dinitrobenzene 871
tyrosine 699
CAT 616
CAT 614
CAT 614
cysteine 579
calcium 468
sodium 464
SDS 444
His 431
pyrene 429
serine 413
hydrogen 407
alanine 406
ATP 368
glucose 355
arginine 333
Clin 333
threonine 312
GSSG 306
phosphate 300
MDA 299
selenium 293
lysine 276
zinc 276
cadmium 269
urea 260
NADPH 252
NADPH 252
copper 243
nitric oxide 238
acetate 232
GTP 228
H2O2 223
ethanol 222
sulfate 219
methionine 212
aflatoxin B1 207
UDP 193
nitrogen 191
iron 188
NAD 186
COS 182
creatinine 181
Phe 179
leucine 177
NAD 174
salt 173
Ile 155
proline 153
TNF 149
anthracene 146
Gly 138
Asp 123
cAMP 120
tryptophan 114
glutamate 112
TOF 111
MTT 110
DEN 108
aniline 106
N-acetylcysteine 98
NH2 96
galactose 96
tryptophan 96
retinoic acid 94
tryptophan 94
tryptophan 94
GDP 94
CCl4 91
ADP 85
silver 84
aldehyde 84
NADH 83
potassium 83
8-OHdG 82
mercury 82
manganese 82
ADP 80
bromide 80
ADP 80
DDP 75
benzene 75
uridine 74
nitrate 72
Pac 72
glutamine 70
ALP 70
aldehyde 69
ammonium 69
DDT 68
salicylic acid 67
dichloromethane 63
AMP 62
nickel 62
Triton X-100 61
PEG 60
methanol 60
pyridine 58
APAP 58
Adriamycin 58
Curcumin 56
DBA 55
naphthalene 55
valine 55
EDTA 53
EDTA 52
PMA 52
AAF 52
PAH 51
DEAE 50
phenol 50
Insulin 50
MEK 50
Malondialdehyde 50
2-nonenal 49
Luminal 49
NTA 49
chromium 49
caffeine 48
DMSO 48
CoA 48
alcohol dehydrogenase 48
Vitamin E 48
Mg2+ 47
1,2-dimethylhydrazine 46
formaldehyde 45
quinoline 42
acrylamide 42
acetone 42
quinoline 42
NADP 41
phenanthrene 41
Arsenic 41
isoleucine 41
acetic acid 41
glycerol 41
PEG 40
isoleucine 40
nicotinamide 40
glutamic acid 40
Ascorbic acid 40
iodine 40
LTC4 39
ammonia 39
Cyt 39
MDR 39
formaldehyde 37
indole-3-carbinol 37
1-naphthol 37
CdCl2 37
aluminum 36
Tyrosine 35
aspartic acid 34
more...