Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.5.1.18 (
glutathione S-transferase
)
22,582
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The retroviral integrase plays an essential role in the integration of reverse-transcribed retroviral cDNA into the host cell genome, and serves as an important target for anti-viral therapeutics. In this study, we identified the
COP9 signalosome subunit 6
(
CSN6
) as a novel avian leukosis virus (ALV) integrase binding protein. Co-immunoprecipitation and
GST
pull-down assays showed that
CSN6
bound to ALV integrase likely through direct interaction of
CSN6
to the catalytic core of the integrase. We further demonstrated
CSN6
inhibited integrase activity in vitro; knockdown of
CSN6
in DF-1 promoted ALV production. These results indicated that
CSN6
may be a negative regulator of ALV replication by binding to and inhibiting integrase. Our findings provided the insight into the integrase-based host defense system and may have implications in the development of integrase-based anti-viral strategies.
...
PMID:COP9 signalosome subunit 6 binds and inhibits avian leukosis virus integrase. 2528 39
