Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.5.1.18 (
glutathione S-transferase
)
22,582
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In this study, changes in
GST
activity before and after treatment with antiparasitic drugs were measured in muscles and sera from mice infected with Trichinella spiralis between the 2nd and 9th weeks post-infection (wpi). Levamisole and albendazole, two anthelmintics with a different mode of action, were used. An about twofold stimulation of
GST
activity in the 2nd wpi and in the later muscular phase (6-7 wpi) was observed in muscles from animals treated with albendazole. In addition, a statistically significant stimulation of
GST
activity was observed after levamisole treatment, however, only from the 2nd()to the 4th wpi. Neither drugs changed the
GST
activity in serum. These results suggest that both anthelmintics seem to increase the total activity of
GST
participating in oxygen free radical-based biochemical defence against
Trichinella infection
.
...
PMID:Changes in the activity of glutathione-S-transferase in muscles and sera from mice infected with Trichinella spiralis after treatment with albendazole and levamisole. 1265 66
The role of glutathione-S-transferase (
GST
,
EC 2.5.1.18
) in biochemical host defence in experimental trichinellosis was evaluated. The activity of
GST
in mouse skeletal muscles was measured during the muscular phase of trichinellosis, starting from the 3rd week post infection (w.p.i.) to the 11th w.p.i. Activity was determined spectrophotometrically by monitoring the formation of thioether (S-2,4-dinitrophenylglutathione) from the reduced form of glutathione and 1-chloro-2,4-dinitrobenzene used as a substrate and as an example of xenobiotics. The changes in the activity of
GST
were as follows: an increase in activity starts in the 4th w.p.i., peaks (up to 310% of the normal value) in the 6th w.p.i., decreases in the 8th week and a final, weak rise was observed in week 11. The statistically significant changes in
GST
activity in this phase of experimental trichinellosis suggest that this enzyme participates in the biochemical defence of the host against
Trichinella infection
.
...
PMID:Glutathione-S-transferase activity in mouse muscle during experimental trichinellosis. 1688 82
