Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.5.1.18 (glutathione S-transferase)
 22,582 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the present study was to investigate the responses of phase I and II biotransformation enzymes and levels of PAHs in the Mediterranean mussel (Mytilus galloprovincialis, Lamarck, 1819) collected from three sites at different distance from an oil refinery. Phase I enzyme activities as NAD(P)H-cyt c red, NADH ferry red, B(a)PMO and phase II as UDPGT, GST were measured in digestive gland while 16 PAHs (US-EPA) in whole soft tissue. An added value to the data obtained in the present study rely on the RDA analysis which showed close correlations between PAHs levels and phase I enzyme activities in mussels collected in front of the refinery. And again a significant spatial correlation between B(a)P levels and NADPH-cyt c red activities was observed using linear models. No differences among sites for B(a)PMO and phase II GST activities were observed, while the application of UDPGT as biomarkers requires further investigation.
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PMID:Phase I and II biotransformation enzymes and polycyclic aromatic hydrocarbons in the Mediterranean mussel (Mytilus galloprovincialis, Lamarck, 1819) collected in front of an oil refinery. 2265 92

The present study aimed to investigate the effects of dimethoate, atrazine and carbendazim on the antioxidant defences and neuronal function of the soil organism Enchytraeus albidus. Effects were studied at concentrations known to affect their reproduction (EC20, EC50 and EC90) and along time (2, 4, 8, 14 and 21 days). In general, responses were more pronounced at periods of exposure longer than 8 days and at the highest concentrations. Multivariate statistics (RDA-PRC) clearly displayed that exposure duration had an effect itself, biomarkers' responses showed interaction for all pesticides and catalase scored consistently high, indicating its relevancy in the group of measured markers. Univariate analysis indicated oxidative stress for all pesticides and atrazine induced oxidative damage in lipids. Atrazine seems to be effectively metabolized by GST of the biotransformation system, as its activity significantly increased after exposure to this pesticide. Dimethoate caused ChE inhibition, indicating an impairment of the neuronal function. Carbendazim impaired the antioxidant system, but no oxidative damage was observed, along with any effects on the ChE activity. The integrated biomarker response analysis was performed but we suggest modifications due to limiting artefacts.
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PMID:Antioxidant and neurotoxicity markers in the model organism Enchytraeus albidus (Oligochaeta): mechanisms of response to atrazine, dimethoate and carbendazim. 2491 78