Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.5.1.18 (
glutathione S-transferase
)
22,582
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Prelamin A accumulation causes nuclear abnormalities, impairs nuclear functions, and eventually promotes cellular senescence. However, the underlying mechanism of how prelamin A promotes cellular senescence is still poorly understood. Here we carried out a yeast two-hybrid screen using a human skeletal muscle cDNA library to search for prelamin A binding partners, and identified
FAM96B
as a prelamin A binding partner. The interaction of
FAM96B
with prelamin A was confirmed by
GST
pull-down and co-immunoprecipitation experiments. Furthermore, co-localization experiments by fluorescent confocal microscopy revealed that
FAM96B
colocalized with prelamin A in HEK-293 cells. Taken together, our data demonstrated the physical interaction between
FAM96B
and prelamin A, which may provide some clues to the mechanisms of prelamin A in premature aging.
...
PMID:Identification of FAM96B as a novel prelamin A binding partner. 2404 93
