Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.99.7 (
sialyltransferase
)
1,534
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A significant elevation of peripheral blood mononuclear cell
sialyltransferase
activity (STA) was observed in 14 patients with multiple myeloma (MM), and compared to 7 patients with
monoclonal gammopathy of undetermined significance
(
MGUS
) and to 10 controls. Serum
sialyltransferase
was significant higher in MM patients as compared to controls. It was also higher than in
MGUS
patients, but the difference here was not statistically significant. STA was also determined in mononuclear bone marrow cells of 5 patients with MM (with 50 to 100% plasma cells in the bone marrow aspirate) and found to be 19 times higher than that of bone marrow mononuclear cells from 6 patients with non-malignant disorders (with less than 1% plasma cells in the bone marrow aspirate). No significant differences were observed in peripheral blood mononuclear cell sialic acid levels between MM,
MGUS
and controls.
...
PMID:Sialyltransferase activity and sialic acid levels in multiple myeloma and monoclonal gammopathy. 292 92
